DegronMD

Uniprot ID: Q8IY92

Source protein: Structure-specific endonuclease subunit SLX4

Source gene: SLX4

Class: LIG_APCC_ABBA_1

Location: 1114:1119

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8271

ASA_SCORE: 91.1833

COIL: 0.8467

CONS_SCORE: 0.3483

DSS_SCORE: 0.5199

HELIX: 0.0377

FCONS_SCORE: 1.0052

RIG_SCORE: 0.7305

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1106M	TCGA-AX-A1CE	UCEC	TCGA	VLMFPE	LIG_APCC_ABBA_1	0.1111
p.V1106M	DO227802	COCA	ICGC	VLMFPE	LIG_APCC_ABBA_1	0.1111
p.V1106M	DO42280	UCEC	ICGC	VLMFPE	LIG_APCC_ABBA_1	0.1111
p.K1120Q	TCGA-D9-A6EC	SKCM	TCGA	VLMFPE	LIG_APCC_ABBA_1	0.75
p.K1120Q	DO50291	SKCM	ICGC	VLMFPE	LIG_APCC_ABBA_1	0.75
p.M1116V	DO230326	COCA	ICGC	VLMFPE	LIG_APCC_ABBA_1	0.6097
p.P1122L	DO229003	COCA	ICGC	VLMFPE	LIG_APCC_ABBA_1	0.25
p.P1122L	DO229505	LAML	ICGC	VLMFPE	LIG_APCC_ABBA_1	0.25
p.Q1128L	DO231204	LUSC	ICGC	VLMFPE	LIG_APCC_ABBA_1	0.0833
p.P1122S	SIDM00545	Melanoma	GDSC	VLMFPE	LIG_APCC_ABBA_1	0.25
p.P1122S	ACH-000987	Skin Cancer	CCLE	VLMFPE	LIG_APCC_ABBA_1	0.25
p.P1122S	Mewo	skin	COSMIC	VLMFPE	LIG_APCC_ABBA_1	0.25
p.S1123P	SIDM00589	Oral Cavity Carcinoma	GDSC	VLMFPE	LIG_APCC_ABBA_1	0.6667
p.S1123P	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	VLMFPE	LIG_APCC_ABBA_1	0.6667
p.S1123P	SIDM00167	Head and Neck Carcinoma	GDSC	VLMFPE	LIG_APCC_ABBA_1	0.6667
p.S1123P	SIDM01611	Endometrial Carcinoma	GDSC	VLMFPE	LIG_APCC_ABBA_1	0.6667
p.S1123P	RC-K8	haematopoietic_and_lymphoid_tissue	COSMIC	VLMFPE	LIG_APCC_ABBA_1	0.6667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IY92	Structure-specific endonuclease subunit SLX4	LIG_APCC_ABBA_1	1114:1119	VLMFPE	APC,CDC20,FZR1	0.8271	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons