DegronMD

Uniprot ID: Q8IY92

Source protein: Structure-specific endonuclease subunit SLX4

Source gene: SLX4

Class: DEG_SCF_FBW7_1

Location: 1257:1264

E3 ligase: FBXW7

DEGRON score: 0.9981

ASA_SCORE: 75.5375

COIL: 0.8945

CONS_SCORE: 0.4057

DSS_SCORE: 0.4762

HELIX: 0.0375

FCONS_SCORE: 1.1477

RIG_SCORE: 0.7621

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1266N	TCGA-A5-A2K5	UCEC	TCGA	VPATPLAS	DEG_SCF_FBW7_1	0.2778
p.S1266N	DO41379	UCEC	ICGC	VPATPLAS	DEG_SCF_FBW7_1	0.2778
p.R1267H	TCGA-A8-A09Z	BRCA	TCGA	VPATPLAS	DEG_SCF_FBW7_1	0.25
p.R1267H	DO5521	BRCA	ICGC	VPATPLAS	DEG_SCF_FBW7_1	0.25
p.P1261S	TCGA-EE-A2MS	SKCM	TCGA	VPATPLAS	DEG_SCF_FBW7_1	0.6752
p.P1261S	DO37567	SKCM	ICGC	VPATPLAS	DEG_SCF_FBW7_1	0.6752
p.E1247K	TCGA-EI-7004	READ	TCGA	VPATPLAS	DEG_SCF_FBW7_1	0.0556
p.E1247K	DO36507	READ	ICGC	VPATPLAS	DEG_SCF_FBW7_1	0.0556
p.P1261Q	TCGA-ER-A19F	SKCM	TCGA	VPATPLAS	DEG_SCF_FBW7_1	0.7035
p.P1261Q	DO37679	SKCM	ICGC	VPATPLAS	DEG_SCF_FBW7_1	0.7035
p.S1271F	DO228941	LICA	ICGC	VPATPLAS	DEG_SCF_FBW7_1	0.5833
p.A1248D	DO229025	LICA	ICGC	VPATPLAS	DEG_SCF_FBW7_1	0.0833
p.T1260P	DO52352	LUSC	ICGC	VPATPLAS	DEG_SCF_FBW7_1	0.8142
p.T1260P	DO50659	ORCA	ICGC	VPATPLAS	DEG_SCF_FBW7_1	0.8142
p.S1249N	SIDM00951	T-Lymphoblastic Leukemia	GDSC	VPATPLAS	DEG_SCF_FBW7_1	0.1111
p.S1249N	ACH-002222	Leukemia	CCLE	VPATPLAS	DEG_SCF_FBW7_1	0.1111
p.S1249N	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	VPATPLAS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IY92	Structure-specific endonuclease subunit SLX4	DEG_SCF_FBW7_1	1257:1264	VPATPLAS	FBXW7	0.9981	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons