DegronMD - Q9HBL0(TNS1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H771Y	TCGA-06-0188	GBM	TCGA	PRASLESVP	DEG_APCC_DBOX_1	780:788	Mutation rewiring degron network	0.0833
p.H771Y	DO12658	GBM	ICGC	PRASLESVP	DEG_APCC_DBOX_1	780:788	Mutation rewiring degron network	0.0833
p.S1098G	TCGA-17-Z062	LUAD	TCGA	ADSTS	DEG_SPOP_SBC_1	1085:1089	Mutation rewiring degron network	0.0833
p.E397Q	TCGA-34-A5IX	LUSC	TCGA	DSGNST	DEG_SCF_TRCP1_1	405:410	Mutation rewiring degron network	0.1111
p.E397Q	DO219136	LUSC	ICGC	DSGNST	DEG_SCF_TRCP1_1	405:410	Mutation rewiring degron network	0.1111
p.G774R	TCGA-50-5935	LUAD	TCGA	PRASLESVP	DEG_APCC_DBOX_1	780:788	Mutation rewiring degron network	0.1667
p.G774R	DO23588	LUAD	ICGC	PRASLESVP	DEG_APCC_DBOX_1	780:788	Mutation rewiring degron network	0.1667
p.S701F	TCGA-55-7570	LUAD	TCGA	LAETPIPS	DEG_SCF_FBW7_1	685:692	Mutation blocking phosphorylation signal	0.5278
p.S701F	DO25280	LUAD	ICGC	LAETPIPS	DEG_SCF_FBW7_1	685:692	Mutation blocking phosphorylation signal	0.5278
p.S701F	DO229465	SKCA	ICGC	LAETPIPS	DEG_SCF_FBW7_1	685:692	Mutation blocking phosphorylation signal	0.5278
p.P824L	TCGA-A5-A0GN	UCEC	TCGA	PASSS	DEG_SPOP_SBC_1	814:818	Mutation rewiring degron network	0.1667
p.P824L	TCGA-B5-A0JY	UCEC	TCGA	PASSS	DEG_SPOP_SBC_1	814:818	Mutation rewiring degron network	0.1667
p.P824L	DO43706	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	814:818	Mutation rewiring degron network	0.1667
p.P824L	DO43041	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	814:818	Mutation rewiring degron network	0.1667
p.R859Q	TCGA-AP-A051	UCEC	TCGA	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.6218
p.R859Q	DO42673	UCEC	ICGC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.6218
p.T1631M	TCGA-AP-A054	UCEC	TCGA	PTPAAT	DEG_SCF_FBW7_1	1630:1635	Mutation altering degron motif	0.7423
p.T1631M	SIDM00216	Colorectal Carcinoma	GDSC	PTPAAT	DEG_SCF_FBW7_1	1630:1635	Mutation altering degron motif	0.7423
p.T1631M	SNU-175	large intestine	COSMIC	PTPAAT	DEG_SCF_FBW7_1	1630:1635	Mutation altering degron motif	0.7423
p.P1630H	TCGA-AP-A1DP	UCEC	TCGA	PTPAAT	DEG_SCF_FBW7_1	1630:1635	Mutation altering degron motif	0.7694
p.G1091V	TCGA-AZ-6600	COAD	TCGA	ADSTS	DEG_SPOP_SBC_1	1085:1089	Mutation rewiring degron network	0.2778
p.N867T	TCGA-B5-A11J	UCEC	TCGA	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation rewiring degron network	0.25
p.N867T	DO43698	UCEC	ICGC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation rewiring degron network	0.25
p.A686T	TCGA-B7-5816	STAD	TCGA	LAETPIPS	DEG_SCF_FBW7_1	685:692	Mutation altering degron motif	0.6028
p.A686T	DO38599	STAD	ICGC	LAETPIPS	DEG_SCF_FBW7_1	685:692	Mutation altering degron motif	0.6028
p.P1094L	TCGA-BR-4201	STAD	TCGA	ADSTS	DEG_SPOP_SBC_1	1085:1089	Mutation rewiring degron network	0.1944
p.P1094L	SIDM00155	Head and Neck Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	1085:1089	Mutation rewiring degron network	0.1944
p.Q683R	TCGA-BR-8589	STAD	TCGA	LAETPIPS	DEG_SCF_FBW7_1	685:692	Mutation rewiring degron network	0.2778
p.Q683R	DO47813	STAD	ICGC	LAETPIPS	DEG_SCF_FBW7_1	685:692	Mutation rewiring degron network	0.2778
p.S849L	TCGA-BT-A0YX	BLCA	TCGA	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation blocking phosphorylation signal	0.5556
p.S849L	DO516	BLCA	ICGC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation blocking phosphorylation signal	0.5556
p.V1637I	TCGA-CA-6717	COAD	TCGA	PTPAAT	DEG_SCF_FBW7_1	1630:1635	Mutation rewiring degron network	0.2778
p.V1637I	TCGA-EO-A3B0	UCEC	TCGA	PTPAAT	DEG_SCF_FBW7_1	1630:1635	Mutation rewiring degron network	0.2778
p.P613T	TCGA-CD-A4MI	STAD	TCGA	PVTTS	DEG_SPOP_SBC_1	603:607	Mutation rewiring degron network	0.1667
p.P613T	DO47717	STAD	ICGC	PVTTS	DEG_SPOP_SBC_1	603:607	Mutation rewiring degron network	0.1667
p.A815V	TCGA-D6-6516	HNSC	TCGA	PASSS	DEG_SPOP_SBC_1	814:818	Mutation altering degron motif	0.5825
p.A815V	DO15623	HNSC	ICGC	PASSS	DEG_SPOP_SBC_1	814:818	Mutation altering degron motif	0.5825
p.V396M	TCGA-DF-A2KN	UCEC	TCGA	DSGNST	DEG_SCF_TRCP1_1	405:410	Mutation rewiring degron network	0.0833
p.V396M	DO223282	UCEC	ICGC	DSGNST	DEG_SCF_TRCP1_1	405:410	Mutation rewiring degron network	0.0833
p.F1639L	TCGA-DK-A3WW	BLCA	TCGA	PTPAAT	DEG_SCF_FBW7_1	1630:1635	Mutation rewiring degron network	0.2222
p.F1639L	SIDM00560	Gastric Carcinoma	GDSC	PTPAAT	DEG_SCF_FBW7_1	1630:1635	Mutation rewiring degron network	0.2222
p.F1639L	MKN7	stomach	COSMIC	PTPAAT	DEG_SCF_FBW7_1	1630:1635	Mutation rewiring degron network	0.2222
p.S1077Y	TCGA-DM-A1DA	COAD	TCGA	PLSTS	DEG_SPOP_SBC_1	1075:1079	Mutation altering degron motif	0.712
p.S1074N	TCGA-E2-A14W	BRCA	TCGA	PLSTS	DEG_SPOP_SBC_1	1075:1079	Mutation rewiring degron network	0.3056
p.Q1644H	TCGA-EE-A2GN	SKCM	TCGA	PTPAAT	DEG_SCF_FBW7_1	1630:1635	Mutation rewiring degron network	0.0833
p.P788L	TCGA-EE-A2MF	SKCM	TCGA	PRASLESVP	DEG_APCC_DBOX_1	780:788	Mutation altering degron motif	0.6471
p.P788L	DO222491	MELA	ICGC	PRASLESVP	DEG_APCC_DBOX_1	780:788	Mutation altering degron motif	0.6471
p.P788L	DO51249	SKCM	ICGC	PRASLESVP	DEG_APCC_DBOX_1	780:788	Mutation altering degron motif	0.6471
p.A873V	TCGA-EO-A22X	UCEC	TCGA	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation rewiring degron network	0.0833
p.A873V	DO43907	UCEC	ICGC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation rewiring degron network	0.0833
p.R781Q	TCGA-EO-A22X	UCEC	TCGA	PRASLESVP	DEG_APCC_DBOX_1	780:788	Mutation altering degron motif	0.7329
p.R781Q	DO230347	COCA	ICGC	PRASLESVP	DEG_APCC_DBOX_1	780:788	Mutation altering degron motif	0.7329
p.R781Q	DO43907	UCEC	ICGC	PRASLESVP	DEG_APCC_DBOX_1	780:788	Mutation altering degron motif	0.7329
p.S1074R	TCGA-EO-A3KX	UCEC	TCGA	PLSTS	DEG_SPOP_SBC_1	1075:1079	Mutation rewiring degron network	0.3056
p.A610S	TCGA-UB-A7MB	LIHC	TCGA	PVTTS	DEG_SPOP_SBC_1	603:607	Mutation rewiring degron network	0.25
p.A610S	DO52318	LIHC	ICGC	PVTTS	DEG_SPOP_SBC_1	603:607	Mutation rewiring degron network	0.25
p.P788S	TCGA-XV-AAZV	SKCM	TCGA	PRASLESVP	DEG_APCC_DBOX_1	780:788	Mutation altering degron motif	0.5641
p.P788S	DO219493	SKCM	ICGC	PRASLESVP	DEG_APCC_DBOX_1	780:788	Mutation altering degron motif	0.5641
p.P788S	SIDM01059	Melanoma	GDSC	PRASLESVP	DEG_APCC_DBOX_1	780:788	Mutation altering degron motif	0.5641
p.P788S	ACH-000915	Skin Cancer	CCLE	PRASLESVP	DEG_APCC_DBOX_1	780:788	Mutation altering degron motif	0.5641
p.P788S	IPC-298	skin	COSMIC	PRASLESVP	DEG_APCC_DBOX_1	780:788	Mutation altering degron motif	0.5641
p.E420K	DO225131	BRCA	ICGC	DSGNST	DEG_SCF_TRCP1_1	405:410	Mutation rewiring degron network	0.0556
p.E420K	DO222749	MELA	ICGC	DSGNST	DEG_SCF_TRCP1_1	405:410	Mutation rewiring degron network	0.0556
p.E420K	SIDM01278	Colorectal Carcinoma	GDSC	DSGNST	DEG_SCF_TRCP1_1	405:410	Mutation rewiring degron network	0.0556
p.R1095H	DO219746	CESC	ICGC	ADSTS	DEG_SPOP_SBC_1	1085:1089	Mutation rewiring degron network	0.1667
p.T1084M	DO9218	COAD	ICGC	PLSTS	DEG_SPOP_SBC_1	1075:1079	Mutation rewiring degron network	0.1944
p.T1084M	DO9218	COAD	ICGC	ADSTS	DEG_SPOP_SBC_1	1085:1089	Mutation rewiring degron network	0.3056
p.G1070V	DO10774	COAD	ICGC	PLSTS	DEG_SPOP_SBC_1	1075:1079	Mutation rewiring degron network	0.1944
p.R1095C	DO222580	COCA	ICGC	ADSTS	DEG_SPOP_SBC_1	1085:1089	Mutation rewiring degron network	0.1667
p.R1095C	DO233487	PRAD	ICGC	ADSTS	DEG_SPOP_SBC_1	1085:1089	Mutation rewiring degron network	0.1667
p.R1095C	DO49823	PRAD	ICGC	ADSTS	DEG_SPOP_SBC_1	1085:1089	Mutation rewiring degron network	0.1667
p.D419E	DO228126	EOPC	ICGC	DSGNST	DEG_SCF_TRCP1_1	405:410	Mutation rewiring degron network	0.0833
p.R1083W	DO234255	ESAD	ICGC	PLSTS	DEG_SPOP_SBC_1	1075:1079	Mutation rewiring degron network	0.2222
p.R1083W	DO234255	ESAD	ICGC	ADSTS	DEG_SPOP_SBC_1	1085:1089	Mutation rewiring degron network	0.2778
p.R1083W	DO38871	STAD	ICGC	PLSTS	DEG_SPOP_SBC_1	1075:1079	Mutation rewiring degron network	0.2222
p.R1083W	DO38871	STAD	ICGC	ADSTS	DEG_SPOP_SBC_1	1085:1089	Mutation rewiring degron network	0.2778
p.R781W	DO218693	GACA	ICGC	PRASLESVP	DEG_APCC_DBOX_1	780:788	Mutation altering degron motif	0.8634
p.R781W	SIDM01048	Plasma Cell Myeloma	GDSC	PRASLESVP	DEG_APCC_DBOX_1	780:788	Mutation altering degron motif	0.8634
p.R781W	SIDM01774	Pancreatic Carcinoma	GDSC	PRASLESVP	DEG_APCC_DBOX_1	780:788	Mutation altering degron motif	0.8634
p.R781W	ACH-000205	Pancreatic Cancer	CCLE	PRASLESVP	DEG_APCC_DBOX_1	780:788	Mutation altering degron motif	0.8634
p.R781W	ACH-000821	Myeloma	CCLE	PRASLESVP	DEG_APCC_DBOX_1	780:788	Mutation altering degron motif	0.8634
p.R781W	EJM	haematopoietic and lymphoid tissue	COSMIC	PRASLESVP	DEG_APCC_DBOX_1	780:788	Mutation altering degron motif	0.8634
p.S681I	DO228750	GACA	ICGC	LAETPIPS	DEG_SCF_FBW7_1	685:692	Mutation blocking phosphorylation signal	0.6667
p.F1094V	DO233206	GACA	ICGC	ADSTS	DEG_SPOP_SBC_1	1085:1089	Mutation rewiring degron network	0.1944
p.H395D	DO233935	GACA	ICGC	DSGNST	DEG_SCF_TRCP1_1	405:410	Mutation rewiring degron network	0.0556
p.L871V	DO228275	LICA	ICGC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation rewiring degron network	0.1389
p.H395Q	DO228952	LICA	ICGC	DSGNST	DEG_SCF_TRCP1_1	405:410	Mutation rewiring degron network	0.0556
p.A1072D	DO228976	LICA	ICGC	PLSTS	DEG_SPOP_SBC_1	1075:1079	Mutation rewiring degron network	0.25
p.D405E	DO229015	LICA	ICGC	DSGNST	DEG_SCF_TRCP1_1	405:410	Mutation altering degron motif	0.6758
p.P865T	DO229032	LICA	ICGC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation rewiring degron network	0.3056
p.T418N	DO229008	LICA	ICGC	DSGNST	DEG_SCF_TRCP1_1	405:410	Mutation rewiring degron network	0.1111
p.S772L	DO50786	LICA	ICGC	PRASLESVP	DEG_APCC_DBOX_1	780:788	Mutation blocking phosphorylation signal	0.5556
p.T1628I	DO23509	LIRI	ICGC	PTPAAT	DEG_SCF_FBW7_1	1630:1635	Mutation rewiring degron network	0.2778
p.R859W	DO231072	LUSC	ICGC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM01139	Pancreatic Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM00944	Colorectal Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM00371	Pancreatic Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM01151	Hepatocellular Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM00186	Kidney Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM01090	Colorectal Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM00454	Rhabdomyosarcoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM00584	Osteosarcoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM00535	Chondrosarcoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM00781	Colorectal Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM00633	Breast Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM00555	Glioblastoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM00315	Glioblastoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM01144	Gastric Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM00856	Other Solid Cancers	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM00296	Small Cell Lung Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM00803	Kidney Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM00589	Oral Cavity Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM00592	Oral Cavity Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM00210	Ovarian Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM00457	Plasma Cell Myeloma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM00694	Other Solid Cancers	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM00878	Breast Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM00879	Breast Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM00487	Colorectal Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM00360	Other Solid Cancers	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM00550	Esophageal Squamous Cell Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM00221	Melanoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM00365	Small Cell Lung Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM00896	B-Cell Non-Hodgkin's Lymphoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM01019	Acute Myeloid Leukemia	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM01651	Non-Cancerous	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM00989	Bladder Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM00494	Non-Small Cell Lung Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM00431	T-Lymphoblastic Leukemia	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM00677	Colorectal Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM00363	Acute Myeloid Leukemia	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM01018	Hodgkin's Lymphoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM00720	Mesothelioma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM00243	Other Solid Cancers	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM00808	Burkitt's Lymphoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM00209	Glioblastoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM00628	Breast Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM01608	Endometrial Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM01577	Plasma Cell Myeloma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM01526	Mesothelioma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM01770	Gastric Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM01611	Endometrial Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM01394	Kidney Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM00780	Colorectal Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM01432	Kidney Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM00959	Acute Myeloid Leukemia	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM01491	Colorectal Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM01451	Pancreatic Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.R859W	SIDM01254	Burkitt's Lymphoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7523
p.S607C	DO229164	NKTL	ICGC	PVTTS	DEG_SPOP_SBC_1	603:607	Mutation altering degron motif	0.8652
p.Y796C	DO32391	OV	ICGC	PRASLESVP	DEG_APCC_DBOX_1	780:788	Mutation blocking phosphorylation signal	0.5556
p.P820L	DO232761	PBCA	ICGC	PASSS	DEG_SPOP_SBC_1	814:818	Mutation rewiring degron network	0.2778
p.R1638H	DO36312	PRAD	ICGC	PTPAAT	DEG_SCF_FBW7_1	1630:1635	Mutation rewiring degron network	0.25
p.P1082T	DO49824	PRAD	ICGC	PLSTS	DEG_SPOP_SBC_1	1075:1079	Mutation rewiring degron network	0.25
p.P1082T	DO49824	PRAD	ICGC	ADSTS	DEG_SPOP_SBC_1	1085:1089	Mutation rewiring degron network	0.25
p.G1624V	DO36556	READ	ICGC	PTPAAT	DEG_SCF_FBW7_1	1630:1635	Mutation rewiring degron network	0.1667
p.P596S	DO229453	SKCA	ICGC	PVTTS	DEG_SPOP_SBC_1	603:607	Mutation rewiring degron network	0.1389
p.Q1623H	DO37896	SKCM	ICGC	PTPAAT	DEG_SCF_FBW7_1	1630:1635	Mutation rewiring degron network	0.1389
p.E1091K	DO50299	SKCM	ICGC	ADSTS	DEG_SPOP_SBC_1	1085:1089	Mutation rewiring degron network	0.2778
p.S1098N	DO50118	STAD	ICGC	ADSTS	DEG_SPOP_SBC_1	1085:1089	Mutation rewiring degron network	0.0833
p.P1073L	DO38707	STAD	ICGC	PLSTS	DEG_SPOP_SBC_1	1075:1079	Mutation rewiring degron network	0.2778
p.E785G	SIDM02059	Colorectal Carcinoma	GDSC	PRASLESVP	DEG_APCC_DBOX_1	780:788	Mutation altering degron motif	0.6087
p.A853V	SIDM00061	Ovarian Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation rewiring degron network	0.2222
p.S813T	SIDM00781	Colorectal Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	814:818	Mutation blocking phosphorylation signal	0.75
p.T1065N	SIDM00855	Other Sarcomas	GDSC	PLSTS	DEG_SPOP_SBC_1	1075:1079	Mutation rewiring degron network	0.0556
p.T1065N	SIDM00309	Mesothelioma	GDSC	PLSTS	DEG_SPOP_SBC_1	1075:1079	Mutation rewiring degron network	0.0556
p.T1065N	SIDM01686	Chronic Myelogenous Leukemia	GDSC	PLSTS	DEG_SPOP_SBC_1	1075:1079	Mutation rewiring degron network	0.0556
p.T1065N	SIDM01409	Bladder Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	1075:1079	Mutation rewiring degron network	0.0556
p.D612N	SIDM00728	Non-Small Cell Lung Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	603:607	Mutation rewiring degron network	0.1944
p.D612N	ACH-000718	Lung Cancer	CCLE	PVTTS	DEG_SPOP_SBC_1	603:607	Mutation rewiring degron network	0.1944
p.D612N	NCI-H2291	lung	COSMIC	PVTTS	DEG_SPOP_SBC_1	603:607	Mutation rewiring degron network	0.1944
p.H810R	SIDM00277	Acute Myeloid Leukemia	GDSC	PASSS	DEG_SPOP_SBC_1	814:818	Mutation rewiring degron network	0.2222
p.H810R	ACH-000198	Leukemia	CCLE	PASSS	DEG_SPOP_SBC_1	814:818	Mutation rewiring degron network	0.2222
p.H810R	EoL-1-cell	haematopoietic and lymphoid tissue	COSMIC	PASSS	DEG_SPOP_SBC_1	814:818	Mutation rewiring degron network	0.2222
p.D419N	SIDM00193	Colorectal Carcinoma	GDSC	DSGNST	DEG_SCF_TRCP1_1	405:410	Mutation rewiring degron network	0.0833
p.D419N	ACH-000991	Colon/Colorectal Cancer	CCLE	DSGNST	DEG_SCF_TRCP1_1	405:410	Mutation rewiring degron network	0.0833
p.D419N	SNU-81	large intestine	COSMIC	DSGNST	DEG_SCF_TRCP1_1	405:410	Mutation rewiring degron network	0.0833
p.G615S	SIDM00571	Pancreatic Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	603:607	Mutation rewiring degron network	0.1111
p.G615S	ACH-000108	Pancreatic Cancer	CCLE	PVTTS	DEG_SPOP_SBC_1	603:607	Mutation rewiring degron network	0.1111
p.G615S	KP-3	pancreas	COSMIC	PVTTS	DEG_SPOP_SBC_1	603:607	Mutation rewiring degron network	0.1111
p.P697S	SIDM00974	Melanoma	GDSC	LAETPIPS	DEG_SCF_FBW7_1	685:692	Mutation rewiring degron network	0.1944
p.P697S	ACH-002207	Skin Cancer	CCLE	LAETPIPS	DEG_SCF_FBW7_1	685:692	Mutation rewiring degron network	0.1944
p.P697S	WM35	skin	COSMIC	LAETPIPS	DEG_SCF_FBW7_1	685:692	Mutation rewiring degron network	0.1944
p.T688N	SIDM00151	Ovarian Carcinoma	GDSC	LAETPIPS	DEG_SCF_FBW7_1	685:692	Mutation altering degron motif	0.8166
p.T688N	ACH-000966	Ovarian Cancer	CCLE	LAETPIPS	DEG_SCF_FBW7_1	685:692	Mutation altering degron motif	0.8166
p.T688N	IGROV-1	ovary	COSMIC	LAETPIPS	DEG_SCF_FBW7_1	685:692	Mutation altering degron motif	0.8166
p.S1098R	SIDM00587	Biliary Tract Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	1085:1089	Mutation rewiring degron network	0.0833
p.D405G	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	DSGNST	DEG_SCF_TRCP1_1	405:410	Mutation altering degron motif	0.7198
p.D405G	ACH-000858	Lung Cancer	CCLE	DSGNST	DEG_SCF_TRCP1_1	405:410	Mutation altering degron motif	0.7198
p.D405G	KNS-62	lung	COSMIC	DSGNST	DEG_SCF_TRCP1_1	405:410	Mutation altering degron motif	0.7198
p.P820S	SIDM00841	Colorectal Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	814:818	Mutation rewiring degron network	0.2778
p.P820S	ACH-000651	Colon/Colorectal Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	814:818	Mutation rewiring degron network	0.2778
p.P820S	SW620	large intestine	COSMIC	PASSS	DEG_SPOP_SBC_1	814:818	Mutation rewiring degron network	0.2778
p.G1067D	SIDM00345	Non-Small Cell Lung Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	1075:1079	Mutation rewiring degron network	0.1111
p.G1067D	LCLC-103H	lung	COSMIC	PLSTS	DEG_SPOP_SBC_1	1075:1079	Mutation rewiring degron network	0.1111
p.P789S	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	PRASLESVP	DEG_APCC_DBOX_1	780:788	Mutation rewiring degron network	0.3056
p.P789S	ACH-000916	Lung Cancer	CCLE	PRASLESVP	DEG_APCC_DBOX_1	780:788	Mutation rewiring degron network	0.3056
p.P789S	NCI-H1573	lung	COSMIC	PRASLESVP	DEG_APCC_DBOX_1	780:788	Mutation rewiring degron network	0.3056
p.F1093L	SIDM00877	Breast Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	1085:1089	Mutation rewiring degron network	0.2222
p.F1093L	HCC1599	breast	COSMIC	ADSTS	DEG_SPOP_SBC_1	1085:1089	Mutation rewiring degron network	0.2222
p.P684S	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	LAETPIPS	DEG_SCF_FBW7_1	685:692	Mutation rewiring degron network	0.3056
p.P684S	ACH-000855	Esophageal Cancer	CCLE	LAETPIPS	DEG_SCF_FBW7_1	685:692	Mutation rewiring degron network	0.3056
p.P684S	KYSE-150	oesophagus	COSMIC	LAETPIPS	DEG_SCF_FBW7_1	685:692	Mutation rewiring degron network	0.3056
p.N806H	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	PASSS	DEG_SPOP_SBC_1	814:818	Mutation rewiring degron network	0.1111
p.S404N	SIDM01609	Endometrial Carcinoma	GDSC	DSGNST	DEG_SCF_TRCP1_1	405:410	Mutation blocking phosphorylation signal	0.75
p.S404N	ACH-000972	Endometrial/Uterine Cancer	CCLE	DSGNST	DEG_SCF_TRCP1_1	405:410	Mutation blocking phosphorylation signal	0.75
p.F1080L	ACH-000196	Breast Cancer	CCLE	PLSTS	DEG_SPOP_SBC_1	1075:1079	Mutation rewiring degron network	0.3056
p.F1080L	ACH-000196	Breast Cancer	CCLE	ADSTS	DEG_SPOP_SBC_1	1085:1089	Mutation rewiring degron network	0.1944
p.F1080L	HCC1599	breast	COSMIC	PLSTS	DEG_SPOP_SBC_1	1075:1079	Mutation rewiring degron network	0.3056
p.F1080L	HCC1599	breast	COSMIC	ADSTS	DEG_SPOP_SBC_1	1085:1089	Mutation rewiring degron network	0.1944
p.F1625L	ACH-000678	Gastric Cancer	CCLE	PTPAAT	DEG_SCF_FBW7_1	1630:1635	Mutation rewiring degron network	0.1944
p.F1625L	MKN7	stomach	COSMIC	PTPAAT	DEG_SCF_FBW7_1	1630:1635	Mutation rewiring degron network	0.1944
p.F1642I	ACH-000702	Lymphoma	CCLE	PTPAAT	DEG_SCF_FBW7_1	1630:1635	Mutation rewiring degron network	0.1389
p.F1642I	L-1236	haematopoietic and lymphoid tissue	COSMIC	PTPAAT	DEG_SCF_FBW7_1	1630:1635	Mutation rewiring degron network	0.1389
p.S678N	ACH-001061	Colon/Colorectal Cancer	CCLE	LAETPIPS	DEG_SCF_FBW7_1	685:692	Mutation rewiring degron network	0.1389
p.S858F	ACH-001569	Skin Cancer	CCLE	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation altering degron motif	0.7982
p.D778N	8505C	thyroid	COSMIC	PRASLESVP	DEG_APCC_DBOX_1	780:788	Mutation rewiring degron network	0.2778
p.D778N	MS-1	lung	COSMIC	PRASLESVP	DEG_APCC_DBOX_1	780:788	Mutation rewiring degron network	0.2778
p.D778N	SKM-1	haematopoietic and lymphoid tissue	COSMIC	PRASLESVP	DEG_APCC_DBOX_1	780:788	Mutation rewiring degron network	0.2778
p.D778N	HT-115	large intestine	COSMIC	PRASLESVP	DEG_APCC_DBOX_1	780:788	Mutation rewiring degron network	0.2778
p.R786Q	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PRASLESVP	DEG_APCC_DBOX_1	780:788	Mutation altering degron motif	0.7329
p.T1094A	MOLM-13	haematopoietic and lymphoid tissue	COSMIC	ADSTS	DEG_SPOP_SBC_1	1085:1089	Mutation rewiring degron network	0.1944
p.G771C	H513	pleura	COSMIC	PRASLESVP	DEG_APCC_DBOX_1	780:788	Mutation rewiring degron network	0.0833
p.T1086A	MOLM-13	haematopoietic and lymphoid tissue	COSMIC	ADSTS	DEG_SPOP_SBC_1	1085:1089	Mutation altering degron motif	0.7139
p.V680I	CP66-MEL	skin	COSMIC	LAETPIPS	DEG_SCF_FBW7_1	685:692	Mutation rewiring degron network	0.1944
p.A815D	SK-N-SH	autonomic ganglia	COSMIC	PASSS	DEG_SPOP_SBC_1	814:818	Mutation altering degron motif	0.6682
p.S1629P	NCI-H1915	lung	COSMIC	PTPAAT	DEG_SCF_FBW7_1	1630:1635	Mutation rewiring degron network	0.3056
p.S1096L	BT-474	breast	COSMIC	ADSTS	DEG_SPOP_SBC_1	1085:1089	Mutation rewiring degron network	0.1389
p.H411R	CCF-STTG1	central nervous system	COSMIC	DSGNST	DEG_SCF_TRCP1_1	405:410	Mutation rewiring degron network	0.3056
p.G689V	MIA-PaCa-2	pancreas	COSMIC	LAETPIPS	DEG_SCF_FBW7_1	685:692	Mutation altering degron motif	0.7532
p.G697D	LCLC-103H	lung	COSMIC	LAETPIPS	DEG_SCF_FBW7_1	685:692	Mutation rewiring degron network	0.1944
p.D1066N	HT-115	large intestine	COSMIC	PLSTS	DEG_SPOP_SBC_1	1075:1079	Mutation rewiring degron network	0.0833
p.F1072L	HCC1599	breast	COSMIC	PLSTS	DEG_SPOP_SBC_1	1075:1079	Mutation rewiring degron network	0.25
p.F1635I	L-1236	haematopoietic and lymphoid tissue	COSMIC	PTPAAT	DEG_SCF_FBW7_1	1630:1635	Mutation altering degron motif	0.7415
p.A405T	LS-411N	large intestine	COSMIC	DSGNST	DEG_SCF_TRCP1_1	405:410	Mutation altering degron motif	0.7139
p.T411I	IA-LM	lung	COSMIC	DSGNST	DEG_SCF_TRCP1_1	405:410	Mutation rewiring degron network	0.3056
p.Q791H	NCI-H2342	lung	COSMIC	PRASLESVP	DEG_APCC_DBOX_1	780:788	Mutation rewiring degron network	0.25
p.S615P	NCI-H1915	lung	COSMIC	PVTTS	DEG_SPOP_SBC_1	603:607	Mutation rewiring degron network	0.1111
p.S854C	NCI-H650	lung	COSMIC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation blocking phosphorylation signal	0.6944
p.P613L	KM12	large intestine	COSMIC	PVTTS	DEG_SPOP_SBC_1	603:607	Mutation rewiring degron network	0.1667
p.A810V	SNU-175	large intestine	COSMIC	PASSS	DEG_SPOP_SBC_1	814:818	Mutation rewiring degron network	0.2222
p.S773R	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	PRASLESVP	DEG_APCC_DBOX_1	780:788	Mutation rewiring degron network	0.1389
p.E819Q	NCI-H1436	lung	COSMIC	PASSS	DEG_SPOP_SBC_1	814:818	Mutation rewiring degron network	0.3056
p.T853P	NCI-H358	lung	COSMIC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation rewiring degron network	0.2222
p.G677R	MZ7-mel	skin	COSMIC	LAETPIPS	DEG_SCF_FBW7_1	685:692	Mutation rewiring degron network	0.1111
p.T853I	TOV-21G	ovary	COSMIC	PSRTPEEE	DEG_SCF_FBW7_2	857:864	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TNS1

UniProt ID: Q9HBL0

Entrez ID: 7145

Protein name: Tensin-1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TNS1 in