DegronMD

Uniprot ID: Q9HBL0

Source protein: Tensin-1

Source gene: TNS1

Class: DEG_APCC_DBOX_1

Location: 780:788

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.958

ASA_SCORE: 81.5667

COIL: 0.8922

CONS_SCORE: 0.3276

DSS_SCORE: 0.6513

HELIX: 0.0654

FCONS_SCORE: 0.9349

RIG_SCORE: 0.6163

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H771Y	TCGA-06-0188	GBM	TCGA	PRASLESVP	DEG_APCC_DBOX_1	0.0833
p.H771Y	DO12658	GBM	ICGC	PRASLESVP	DEG_APCC_DBOX_1	0.0833
p.G774R	TCGA-50-5935	LUAD	TCGA	PRASLESVP	DEG_APCC_DBOX_1	0.1667
p.G774R	DO23588	LUAD	ICGC	PRASLESVP	DEG_APCC_DBOX_1	0.1667
p.P788L	TCGA-EE-A2MF	SKCM	TCGA	PRASLESVP	DEG_APCC_DBOX_1	0.6471
p.P788L	DO222491	MELA	ICGC	PRASLESVP	DEG_APCC_DBOX_1	0.6471
p.P788L	DO51249	SKCM	ICGC	PRASLESVP	DEG_APCC_DBOX_1	0.6471
p.R781Q	TCGA-EO-A22X	UCEC	TCGA	PRASLESVP	DEG_APCC_DBOX_1	0.7329
p.R781Q	DO230347	COCA	ICGC	PRASLESVP	DEG_APCC_DBOX_1	0.7329
p.R781Q	DO43907	UCEC	ICGC	PRASLESVP	DEG_APCC_DBOX_1	0.7329
p.P788S	TCGA-XV-AAZV	SKCM	TCGA	PRASLESVP	DEG_APCC_DBOX_1	0.5641
p.P788S	DO219493	SKCM	ICGC	PRASLESVP	DEG_APCC_DBOX_1	0.5641
p.P788S	SIDM01059	Melanoma	GDSC	PRASLESVP	DEG_APCC_DBOX_1	0.5641
p.P788S	ACH-000915	Skin Cancer	CCLE	PRASLESVP	DEG_APCC_DBOX_1	0.5641
p.P788S	IPC-298	skin	COSMIC	PRASLESVP	DEG_APCC_DBOX_1	0.5641
p.R781W	DO218693	GACA	ICGC	PRASLESVP	DEG_APCC_DBOX_1	0.8634
p.R781W	SIDM01048	Plasma Cell Myeloma	GDSC	PRASLESVP	DEG_APCC_DBOX_1	0.8634
p.R781W	SIDM01774	Pancreatic Carcinoma	GDSC	PRASLESVP	DEG_APCC_DBOX_1	0.8634
p.R781W	ACH-000205	Pancreatic Cancer	CCLE	PRASLESVP	DEG_APCC_DBOX_1	0.8634
p.R781W	ACH-000821	Myeloma	CCLE	PRASLESVP	DEG_APCC_DBOX_1	0.8634
p.R781W	EJM	haematopoietic_and_lymphoid_tissue	COSMIC	PRASLESVP	DEG_APCC_DBOX_1	0.8634
p.S772L	DO50786	LICA	ICGC	PRASLESVP	DEG_APCC_DBOX_1	0.5556
p.Y796C	DO32391	OV	ICGC	PRASLESVP	DEG_APCC_DBOX_1	0.5556
p.E785G	SIDM02059	Colorectal Carcinoma	GDSC	PRASLESVP	DEG_APCC_DBOX_1	0.6087
p.P789S	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	PRASLESVP	DEG_APCC_DBOX_1	0.3056
p.P789S	ACH-000916	Lung Cancer	CCLE	PRASLESVP	DEG_APCC_DBOX_1	0.3056
p.P789S	NCI-H1573	lung	COSMIC	PRASLESVP	DEG_APCC_DBOX_1	0.3056
p.D778N	8505C	thyroid	COSMIC	PRASLESVP	DEG_APCC_DBOX_1	0.2778
p.D778N	MS-1	lung	COSMIC	PRASLESVP	DEG_APCC_DBOX_1	0.2778
p.D778N	SKM-1	haematopoietic_and_lymphoid_tissue	COSMIC	PRASLESVP	DEG_APCC_DBOX_1	0.2778
p.D778N	HT-115	large_intestine	COSMIC	PRASLESVP	DEG_APCC_DBOX_1	0.2778
p.R786Q	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	PRASLESVP	DEG_APCC_DBOX_1	0.7329
p.G771C	H513	pleura	COSMIC	PRASLESVP	DEG_APCC_DBOX_1	0.0833
p.Q791H	NCI-H2342	lung	COSMIC	PRASLESVP	DEG_APCC_DBOX_1	0.25
p.S773R	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	PRASLESVP	DEG_APCC_DBOX_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRASLESVP

Degron related mutations and impact score

Drug responses associated with TNS1 mutations

All proteins holding degron of PRASLESVP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HBL0	Tensin-1	DEG_APCC_DBOX_1	780:788	PRASLESVP	APC,CDC20,FZR1	0.958	More...