DegronMD

Uniprot ID: Q9HBL0

Source protein: Tensin-1

Source gene: TNS1

Class: DEG_SCF_FBW7_1

Location: 1630:1635

E3 ligase: FBXW7

DEGRON score: 0.8724

ASA_SCORE: 52.7333

COIL: 0.6727

CONS_SCORE: 0.4246

DSS_SCORE: 0.3084

HELIX: 0.0097

FCONS_SCORE: 0.9664

RIG_SCORE: 0.7436

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1631M	TCGA-AP-A054	UCEC	TCGA	PTPAAT	DEG_SCF_FBW7_1	0.7423
p.T1631M	SIDM00216	Colorectal Carcinoma	GDSC	PTPAAT	DEG_SCF_FBW7_1	0.7423
p.T1631M	SNU-175	large_intestine	COSMIC	PTPAAT	DEG_SCF_FBW7_1	0.7423
p.P1630H	TCGA-AP-A1DP	UCEC	TCGA	PTPAAT	DEG_SCF_FBW7_1	0.7694
p.V1637I	TCGA-CA-6717	COAD	TCGA	PTPAAT	DEG_SCF_FBW7_1	0.2778
p.V1637I	TCGA-EO-A3B0	UCEC	TCGA	PTPAAT	DEG_SCF_FBW7_1	0.2778
p.F1639L	TCGA-DK-A3WW	BLCA	TCGA	PTPAAT	DEG_SCF_FBW7_1	0.2222
p.F1639L	SIDM00560	Gastric Carcinoma	GDSC	PTPAAT	DEG_SCF_FBW7_1	0.2222
p.F1639L	MKN7	stomach	COSMIC	PTPAAT	DEG_SCF_FBW7_1	0.2222
p.Q1644H	TCGA-EE-A2GN	SKCM	TCGA	PTPAAT	DEG_SCF_FBW7_1	0.0833
p.T1628I	DO23509	LIRI	ICGC	PTPAAT	DEG_SCF_FBW7_1	0.2778
p.R1638H	DO36312	PRAD	ICGC	PTPAAT	DEG_SCF_FBW7_1	0.25
p.G1624V	DO36556	READ	ICGC	PTPAAT	DEG_SCF_FBW7_1	0.1667
p.Q1623H	DO37896	SKCM	ICGC	PTPAAT	DEG_SCF_FBW7_1	0.1389
p.F1625L	ACH-000678	Gastric Cancer	CCLE	PTPAAT	DEG_SCF_FBW7_1	0.1944
p.F1625L	MKN7	stomach	COSMIC	PTPAAT	DEG_SCF_FBW7_1	0.1944
p.F1642I	ACH-000702	Lymphoma	CCLE	PTPAAT	DEG_SCF_FBW7_1	0.1389
p.F1642I	L-1236	haematopoietic_and_lymphoid_tissue	COSMIC	PTPAAT	DEG_SCF_FBW7_1	0.1389
p.S1629P	NCI-H1915	lung	COSMIC	PTPAAT	DEG_SCF_FBW7_1	0.3056
p.F1635I	L-1236	haematopoietic_and_lymphoid_tissue	COSMIC	PTPAAT	DEG_SCF_FBW7_1	0.7415

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95359	Transforming acidic coiled-coil-containing protein 2	DEG_SCF_FBW7_1	2450:2455	PTPAAT	FBXW7	0.9794	More...
Q9HBL0	Tensin-1	DEG_SCF_FBW7_1	1630:1635	PTPAAT	FBXW7	0.8724	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons