DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PTPAAT
Uniprot ID:
O95359
Source protein:
Transforming acidic coiled-coil-containing protein 2
Source gene:
TACC2
Class:
DEG_SCF_FBW7_1
Location:
2450:2455
E3 ligase:
FBXW7
DEGRON score:
0.9794
ASA_SCORE:
83.8
COIL:
0.9618
CONS_SCORE:
0.5677
DSS_SCORE:
0.7736
HELIX:
0.0143
FCONS_SCORE:
0.9738
RIG_SCORE:
0.557
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.I2462M
TCGA-BA-5152
HNSC
TCGA
PTPAAT
DEG_SCF_FBW7_1
0.1389
p.P2452T
TCGA-GN-A262
SKCM
TCGA
PTPAAT
DEG_SCF_FBW7_1
0.7031
Drug responses associated with TACC2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PTPAAT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O95359
Transforming acidic coiled-coil-containing protein 2
DEG_SCF_FBW7_1
2450:2455
PTPAAT
FBXW7
0.9794
More...
Q9HBL0
Tensin-1
DEG_SCF_FBW7_1
1630:1635
PTPAAT
FBXW7
0.8724
More...