DegronMD

Uniprot ID: Q9HBL0

Source protein: Tensin-1

Source gene: TNS1

Class: DEG_SCF_TRCP1_1

Location: 405:410

E3 ligase: BTRC

DEGRON score: 0.9978

ASA_SCORE: 77.2667

COIL: 0.9037

CONS_SCORE: 0.3917

DSS_SCORE: 0.6325

HELIX: 0.0573

FCONS_SCORE: 1.0202

RIG_SCORE: 0.5371

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E397Q	TCGA-34-A5IX	LUSC	TCGA	DSGNST	DEG_SCF_TRCP1_1	0.1111
p.E397Q	DO219136	LUSC	ICGC	DSGNST	DEG_SCF_TRCP1_1	0.1111
p.V396M	TCGA-DF-A2KN	UCEC	TCGA	DSGNST	DEG_SCF_TRCP1_1	0.0833
p.V396M	DO223282	UCEC	ICGC	DSGNST	DEG_SCF_TRCP1_1	0.0833
p.E420K	DO225131	BRCA	ICGC	DSGNST	DEG_SCF_TRCP1_1	0.0556
p.E420K	DO222749	MELA	ICGC	DSGNST	DEG_SCF_TRCP1_1	0.0556
p.E420K	SIDM01278	Colorectal Carcinoma	GDSC	DSGNST	DEG_SCF_TRCP1_1	0.0556
p.D419E	DO228126	EOPC	ICGC	DSGNST	DEG_SCF_TRCP1_1	0.0833
p.H395D	DO233935	GACA	ICGC	DSGNST	DEG_SCF_TRCP1_1	0.0556
p.H395Q	DO228952	LICA	ICGC	DSGNST	DEG_SCF_TRCP1_1	0.0556
p.D405E	DO229015	LICA	ICGC	DSGNST	DEG_SCF_TRCP1_1	0.6758
p.T418N	DO229008	LICA	ICGC	DSGNST	DEG_SCF_TRCP1_1	0.1111
p.D419N	SIDM00193	Colorectal Carcinoma	GDSC	DSGNST	DEG_SCF_TRCP1_1	0.0833
p.D419N	ACH-000991	Colon/Colorectal Cancer	CCLE	DSGNST	DEG_SCF_TRCP1_1	0.0833
p.D419N	SNU-81	large_intestine	COSMIC	DSGNST	DEG_SCF_TRCP1_1	0.0833
p.D405G	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	DSGNST	DEG_SCF_TRCP1_1	0.7198
p.D405G	ACH-000858	Lung Cancer	CCLE	DSGNST	DEG_SCF_TRCP1_1	0.7198
p.D405G	KNS-62	lung	COSMIC	DSGNST	DEG_SCF_TRCP1_1	0.7198
p.S404N	SIDM01609	Endometrial Carcinoma	GDSC	DSGNST	DEG_SCF_TRCP1_1	0.75
p.S404N	ACH-000972	Endometrial/Uterine Cancer	CCLE	DSGNST	DEG_SCF_TRCP1_1	0.75
p.H411R	CCF-STTG1	central_nervous_system	COSMIC	DSGNST	DEG_SCF_TRCP1_1	0.3056
p.A405T	LS-411N	large_intestine	COSMIC	DSGNST	DEG_SCF_TRCP1_1	0.7139
p.T411I	IA-LM	lung	COSMIC	DSGNST	DEG_SCF_TRCP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HBL0	Tensin-1	DEG_SCF_TRCP1_1	405:410	DSGNST	BTRC	0.9978	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons