DegronMD

Uniprot ID: Q9HBL0

Source protein: Tensin-1

Source gene: TNS1

Class: DEG_SCF_FBW7_2

Location: 857:864

E3 ligase: FBXW7

DEGRON score: 0.9715

ASA_SCORE: 105.5125

COIL: 0.9344

CONS_SCORE: 0.3415

DSS_SCORE: 0.7797

HELIX: 0.0546

FCONS_SCORE: 0.8854

RIG_SCORE: 0.6127

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R859Q	TCGA-AP-A051	UCEC	TCGA	PSRTPEEE	DEG_SCF_FBW7_2	0.6218
p.R859Q	DO42673	UCEC	ICGC	PSRTPEEE	DEG_SCF_FBW7_2	0.6218
p.N867T	TCGA-B5-A11J	UCEC	TCGA	PSRTPEEE	DEG_SCF_FBW7_2	0.25
p.N867T	DO43698	UCEC	ICGC	PSRTPEEE	DEG_SCF_FBW7_2	0.25
p.S849L	TCGA-BT-A0YX	BLCA	TCGA	PSRTPEEE	DEG_SCF_FBW7_2	0.5556
p.S849L	DO516	BLCA	ICGC	PSRTPEEE	DEG_SCF_FBW7_2	0.5556
p.A873V	TCGA-EO-A22X	UCEC	TCGA	PSRTPEEE	DEG_SCF_FBW7_2	0.0833
p.A873V	DO43907	UCEC	ICGC	PSRTPEEE	DEG_SCF_FBW7_2	0.0833
p.L871V	DO228275	LICA	ICGC	PSRTPEEE	DEG_SCF_FBW7_2	0.1389
p.P865T	DO229032	LICA	ICGC	PSRTPEEE	DEG_SCF_FBW7_2	0.3056
p.R859W	DO231072	LUSC	ICGC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM01139	Pancreatic Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM00944	Colorectal Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM00371	Pancreatic Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM01151	Hepatocellular Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM00186	Kidney Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM01090	Colorectal Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM00454	Rhabdomyosarcoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM00584	Osteosarcoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM00535	Chondrosarcoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM00781	Colorectal Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM00633	Breast Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM00555	Glioblastoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM00315	Glioblastoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM01144	Gastric Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM00856	Other Solid Cancers	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM00296	Small Cell Lung Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM00803	Kidney Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM00589	Oral Cavity Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM00592	Oral Cavity Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM00210	Ovarian Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM00457	Plasma Cell Myeloma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM00694	Other Solid Cancers	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM00878	Breast Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM00879	Breast Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM00487	Colorectal Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM00360	Other Solid Cancers	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM00550	Esophageal Squamous Cell Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM00221	Melanoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM00365	Small Cell Lung Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM00896	B-Cell Non-Hodgkin's Lymphoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM01019	Acute Myeloid Leukemia	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM01651	Non-Cancerous	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM00989	Bladder Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM00494	Non-Small Cell Lung Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM00431	T-Lymphoblastic Leukemia	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM00677	Colorectal Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM00363	Acute Myeloid Leukemia	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM01018	Hodgkin's Lymphoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM00720	Mesothelioma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM00243	Other Solid Cancers	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM00808	Burkitt's Lymphoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM00209	Glioblastoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM00628	Breast Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM01608	Endometrial Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM01577	Plasma Cell Myeloma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM01526	Mesothelioma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM01770	Gastric Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM01611	Endometrial Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM01394	Kidney Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM00780	Colorectal Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM01432	Kidney Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM00959	Acute Myeloid Leukemia	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM01491	Colorectal Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM01451	Pancreatic Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.R859W	SIDM01254	Burkitt's Lymphoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.7523
p.A853V	SIDM00061	Ovarian Carcinoma	GDSC	PSRTPEEE	DEG_SCF_FBW7_2	0.2222
p.S858F	ACH-001569	Skin Cancer	CCLE	PSRTPEEE	DEG_SCF_FBW7_2	0.7982
p.S854C	NCI-H650	lung	COSMIC	PSRTPEEE	DEG_SCF_FBW7_2	0.6944
p.T853P	NCI-H358	lung	COSMIC	PSRTPEEE	DEG_SCF_FBW7_2	0.2222
p.T853I	TOV-21G	ovary	COSMIC	PSRTPEEE	DEG_SCF_FBW7_2	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSRTPEEE

Degron related mutations and impact score

Drug responses associated with TNS1 mutations

All proteins holding degron of PSRTPEEE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HBL0	Tensin-1	DEG_SCF_FBW7_2	857:864	PSRTPEEE	FBXW7	0.9715	More...