DegronMD

Uniprot ID: Q9HBL0

Source protein: Tensin-1

Source gene: TNS1

Class: DEG_SCF_FBW7_1

Location: 685:692

E3 ligase: FBXW7

DEGRON score: 0.8187

ASA_SCORE: 89.9375

COIL: 0.9469

CONS_SCORE: 0.3622

DSS_SCORE: 0.695

HELIX: 0.025

FCONS_SCORE: 0.9372

RIG_SCORE: 0.6255

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S701F	TCGA-55-7570	LUAD	TCGA	LAETPIPS	DEG_SCF_FBW7_1	0.5278
p.S701F	DO25280	LUAD	ICGC	LAETPIPS	DEG_SCF_FBW7_1	0.5278
p.S701F	DO229465	SKCA	ICGC	LAETPIPS	DEG_SCF_FBW7_1	0.5278
p.A686T	TCGA-B7-5816	STAD	TCGA	LAETPIPS	DEG_SCF_FBW7_1	0.6028
p.A686T	DO38599	STAD	ICGC	LAETPIPS	DEG_SCF_FBW7_1	0.6028
p.Q683R	TCGA-BR-8589	STAD	TCGA	LAETPIPS	DEG_SCF_FBW7_1	0.2778
p.Q683R	DO47813	STAD	ICGC	LAETPIPS	DEG_SCF_FBW7_1	0.2778
p.S681I	DO228750	GACA	ICGC	LAETPIPS	DEG_SCF_FBW7_1	0.6667
p.P697S	SIDM00974	Melanoma	GDSC	LAETPIPS	DEG_SCF_FBW7_1	0.1944
p.P697S	ACH-002207	Skin Cancer	CCLE	LAETPIPS	DEG_SCF_FBW7_1	0.1944
p.P697S	WM35	skin	COSMIC	LAETPIPS	DEG_SCF_FBW7_1	0.1944
p.T688N	SIDM00151	Ovarian Carcinoma	GDSC	LAETPIPS	DEG_SCF_FBW7_1	0.8166
p.T688N	ACH-000966	Ovarian Cancer	CCLE	LAETPIPS	DEG_SCF_FBW7_1	0.8166
p.T688N	IGROV-1	ovary	COSMIC	LAETPIPS	DEG_SCF_FBW7_1	0.8166
p.P684S	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	LAETPIPS	DEG_SCF_FBW7_1	0.3056
p.P684S	ACH-000855	Esophageal Cancer	CCLE	LAETPIPS	DEG_SCF_FBW7_1	0.3056
p.P684S	KYSE-150	oesophagus	COSMIC	LAETPIPS	DEG_SCF_FBW7_1	0.3056
p.S678N	ACH-001061	Colon/Colorectal Cancer	CCLE	LAETPIPS	DEG_SCF_FBW7_1	0.1389
p.V680I	CP66-MEL	skin	COSMIC	LAETPIPS	DEG_SCF_FBW7_1	0.1944
p.G689V	MIA-PaCa-2	pancreas	COSMIC	LAETPIPS	DEG_SCF_FBW7_1	0.7532
p.G697D	LCLC-103H	lung	COSMIC	LAETPIPS	DEG_SCF_FBW7_1	0.1944
p.G677R	MZ7-mel	skin	COSMIC	LAETPIPS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HBL0	Tensin-1	DEG_SCF_FBW7_1	685:692	LAETPIPS	FBXW7	0.8187	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons