DegronMD

Uniprot ID: Q9HBL0

Source protein: Tensin-1

Source gene: TNS1

Class: DEG_SPOP_SBC_1

Location: 1085:1089

E3 ligase: SPOP

DEGRON score: 0.9906

ASA_SCORE: 72.32

COIL: 0.878

CONS_SCORE: 0.3161

DSS_SCORE: 0.569

HELIX: 0.0746

FCONS_SCORE: 0.8277

RIG_SCORE: 0.6219

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1098G	TCGA-17-Z062	LUAD	TCGA	ADSTS	DEG_SPOP_SBC_1	0.0833
p.G1091V	TCGA-AZ-6600	COAD	TCGA	ADSTS	DEG_SPOP_SBC_1	0.2778
p.P1094L	TCGA-BR-4201	STAD	TCGA	ADSTS	DEG_SPOP_SBC_1	0.1944
p.P1094L	SIDM00155	Head and Neck Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	0.1944
p.R1095H	DO219746	CESC	ICGC	ADSTS	DEG_SPOP_SBC_1	0.1667
p.T1084M	DO9218	COAD	ICGC	ADSTS	DEG_SPOP_SBC_1	0.3056
p.R1095C	DO222580	COCA	ICGC	ADSTS	DEG_SPOP_SBC_1	0.1667
p.R1095C	DO233487	PRAD	ICGC	ADSTS	DEG_SPOP_SBC_1	0.1667
p.R1095C	DO49823	PRAD	ICGC	ADSTS	DEG_SPOP_SBC_1	0.1667
p.R1083W	DO234255	ESAD	ICGC	ADSTS	DEG_SPOP_SBC_1	0.2778
p.R1083W	DO38871	STAD	ICGC	ADSTS	DEG_SPOP_SBC_1	0.2778
p.F1094V	DO233206	GACA	ICGC	ADSTS	DEG_SPOP_SBC_1	0.1944
p.P1082T	DO49824	PRAD	ICGC	ADSTS	DEG_SPOP_SBC_1	0.25
p.E1091K	DO50299	SKCM	ICGC	ADSTS	DEG_SPOP_SBC_1	0.2778
p.S1098N	DO50118	STAD	ICGC	ADSTS	DEG_SPOP_SBC_1	0.0833
p.S1098R	SIDM00587	Biliary Tract Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	0.0833
p.F1093L	SIDM00877	Breast Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	0.2222
p.F1093L	HCC1599	breast	COSMIC	ADSTS	DEG_SPOP_SBC_1	0.2222
p.F1080L	ACH-000196	Breast Cancer	CCLE	ADSTS	DEG_SPOP_SBC_1	0.1944
p.F1080L	HCC1599	breast	COSMIC	ADSTS	DEG_SPOP_SBC_1	0.1944
p.T1094A	MOLM-13	haematopoietic_and_lymphoid_tissue	COSMIC	ADSTS	DEG_SPOP_SBC_1	0.1944
p.T1086A	MOLM-13	haematopoietic_and_lymphoid_tissue	COSMIC	ADSTS	DEG_SPOP_SBC_1	0.7139
p.S1096L	BT-474	breast	COSMIC	ADSTS	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P25054	Adenomatous polyposis coli protein	DEG_SPOP_SBC_1	2795:2799	ADSTS	SPOP	0.9671	More...
Q27J81	Inverted formin-2	DEG_SPOP_SBC_1	1145:1149	ADSTS	SPOP	0.9983	More...
Q5VUA4	Zinc finger protein 318	DEG_SPOP_SBC_1	515:519	ADSTS	SPOP	0.9834	More...
Q6VMQ6	Activating transcription factor 7-interacting protein 1	DEG_SPOP_SBC_1	949:953	ADSTS	SPOP	0.8767	More...
Q99684	Zinc finger protein Gfi-1	DEG_SPOP_SBC_1	38:42	ADSTS	SPOP	0.833	More...
Q9HBL0	Tensin-1	DEG_SPOP_SBC_1	1085:1089	ADSTS	SPOP	0.9906	More...
Q7Z2K8	G protein-regulated inducer of neurite outgrowth 1	DEG_SPOP_SBC_1	161:165	ADSTS	SPOP	0.9942	More...
Q9C0D7	Probable ribonuclease ZC3H12C	DEG_SPOP_SBC_1	476:480	ADSTS	SPOP	0.9991	More...
O60320	Protein FAM189A1	DEG_SPOP_SBC_1	337:341	ADSTS	SPOP	0.919	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons