DegronMD

Uniprot ID: P25054

Source protein: Adenomatous polyposis coli protein

Source gene: APC

Class: DEG_SPOP_SBC_1

Location: 2795:2799

E3 ligase: SPOP

DEGRON score: 0.9671

ASA_SCORE: 90.28

COIL: 0.9438

CONS_SCORE: 0.2823

DSS_SCORE: 0.7504

HELIX: 0.045

FCONS_SCORE: 0.5939

RIG_SCORE: 0.5754

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P2808A	TCGA-29-1776	OV	TCGA	ADSTS	DEG_SPOP_SBC_1	0.0833
p.P2808A	DO30810	OV	ICGC	ADSTS	DEG_SPOP_SBC_1	0.0833
p.S2794I	TCGA-29-1781	OV	TCGA	ADSTS	DEG_SPOP_SBC_1	0.75
p.S2794I	DO29578	OV	ICGC	ADSTS	DEG_SPOP_SBC_1	0.75
p.S2794T	TCGA-43-2581	LUSC	TCGA	ADSTS	DEG_SPOP_SBC_1	0.75
p.S2794T	DO26602	LUSC	ICGC	ADSTS	DEG_SPOP_SBC_1	0.75
p.R2801W	TCGA-AA-A00N	COAD	TCGA	ADSTS	DEG_SPOP_SBC_1	0.2778
p.R2801W	DO9876	COAD	ICGC	ADSTS	DEG_SPOP_SBC_1	0.2778
p.Q2804P	TCGA-WC-AA9A	UVM	TCGA	ADSTS	DEG_SPOP_SBC_1	0.1944
p.R2791W	DO228194	LICA	ICGC	ADSTS	DEG_SPOP_SBC_1	0.2222
p.S2793I	DO229045	LICA	ICGC	ADSTS	DEG_SPOP_SBC_1	0.7222
p.D2796G	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	0.6087
p.D2796G	ACH-000878	Lung Cancer	CCLE	ADSTS	DEG_SPOP_SBC_1	0.6087
p.D2796G	HCC-15	lung	COSMIC	ADSTS	DEG_SPOP_SBC_1	0.6087

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P25054	Adenomatous polyposis coli protein	DEG_SPOP_SBC_1	2795:2799	ADSTS	SPOP	0.9671	More...
Q27J81	Inverted formin-2	DEG_SPOP_SBC_1	1145:1149	ADSTS	SPOP	0.9983	More...
Q5VUA4	Zinc finger protein 318	DEG_SPOP_SBC_1	515:519	ADSTS	SPOP	0.9834	More...
Q6VMQ6	Activating transcription factor 7-interacting protein 1	DEG_SPOP_SBC_1	949:953	ADSTS	SPOP	0.8767	More...
Q99684	Zinc finger protein Gfi-1	DEG_SPOP_SBC_1	38:42	ADSTS	SPOP	0.833	More...
Q9HBL0	Tensin-1	DEG_SPOP_SBC_1	1085:1089	ADSTS	SPOP	0.9906	More...
Q7Z2K8	G protein-regulated inducer of neurite outgrowth 1	DEG_SPOP_SBC_1	161:165	ADSTS	SPOP	0.9942	More...
Q9C0D7	Probable ribonuclease ZC3H12C	DEG_SPOP_SBC_1	476:480	ADSTS	SPOP	0.9991	More...
O60320	Protein FAM189A1	DEG_SPOP_SBC_1	337:341	ADSTS	SPOP	0.919	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons