DegronMD - O60320(FAM189A1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E299K	TCGA-A5-A0VQ	UCEC	TCGA	PPPY	ITCH	295:298	Mutation rewiring degron network	0.3056
p.E299K	DO42113	UCEC	ICGC	PPPY	ITCH	295:298	Mutation rewiring degron network	0.3056
p.E299K	SIDM01175	Other Sarcomas	GDSC	PPPY	ITCH	295:298	Mutation rewiring degron network	0.3056
p.E299K	ACH-002309	Sarcoma	CCLE	PPPY	ITCH	295:298	Mutation rewiring degron network	0.3056
p.E299K	SW684	soft tissue	COSMIC	PPPY	ITCH	295:298	Mutation rewiring degron network	0.3056
p.G287S	TCGA-EO-A22U	UCEC	TCGA	PPPY	ITCH	295:298	Mutation rewiring degron network	0.1111
p.G287S	DO220878	MELA	ICGC	PPPY	ITCH	295:298	Mutation rewiring degron network	0.1111
p.G287S	DO218554	ORCA	ICGC	PPPY	ITCH	295:298	Mutation rewiring degron network	0.1111
p.G287S	DO43755	UCEC	ICGC	PPPY	ITCH	295:298	Mutation rewiring degron network	0.1111
p.P247S	TCGA-L5-A4OR	ESCA	TCGA	PPPY	ITCH	246:249	Mutation altering degron motif	0.6752
p.P243L	TCGA-RC-A6M4	LIHC	TCGA	PPPY	ITCH	246:249	Mutation rewiring degron network	0.25
p.P243L	TCGA-RC-A6M4	LIHC	TCGA	PPEY	ITCH	251:254	Mutation rewiring degron network	0.1111
p.P243L	DO223915	LIHC	ICGC	PPPY	ITCH	246:249	Mutation rewiring degron network	0.25
p.P243L	DO223915	LIHC	ICGC	PPEY	ITCH	251:254	Mutation rewiring degron network	0.1111
p.V230I	TCGA-ZB-A966	THYM	TCGA	VTPHGT	DEG_SCF_FBW7_1	224:229	Mutation rewiring degron network	0.3056
p.V230I	ACH-001518	Endometrial/Uterine Cancer	CCLE	VTPHGT	DEG_SCF_FBW7_1	224:229	Mutation rewiring degron network	0.3056
p.G314D	DO228483	BRCA	ICGC	AESSS	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.2222
p.G314D	DO229016	COCA	ICGC	AESSS	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.2222
p.G314D	DO234285	ESAD	ICGC	AESSS	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.2222
p.G314D	DO229505	LAML	ICGC	AESSS	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.2222
p.G314D	DO52369	LUSC	ICGC	AESSS	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.2222
p.E346K	DO222492	COCA	ICGC	ADSTS	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.1944
p.E346K	SIDM01945	Colorectal Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.1944
p.S308I	DO233108	GACA	ICGC	AESSS	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.0556
p.S308I	DO233108	GACA	ICGC	PPPY	ITCH	295:298	Mutation rewiring degron network	0.0556
p.R264K	DO233636	GACA	ICGC	PPEY	ITCH	251:254	Mutation rewiring degron network	0.0556
p.L289I	DO233618	GACA	ICGC	PPPY	ITCH	295:298	Mutation rewiring degron network	0.1667
p.L289I	DO228952	LICA	ICGC	PPPY	ITCH	295:298	Mutation rewiring degron network	0.1667
p.S339I	DO233885	GACA	ICGC	ADSTS	DEG_SPOP_SBC_1	337:341	Mutation altering degron motif	0.7341
p.P252S	DO50970	LICA	ICGC	PPEY	ITCH	251:254	Mutation altering degron motif	0.6752
p.P297L	DO231057	LUSC	ICGC	PPPY	ITCH	295:298	Mutation altering degron motif	0.6471
p.P297L	DO220877	MELA	ICGC	PPPY	ITCH	295:298	Mutation altering degron motif	0.6471
p.P297L	DO220886	MELA	ICGC	PPPY	ITCH	295:298	Mutation altering degron motif	0.6471
p.G228S	DO231075	LUSC	ICGC	VTPHGT	DEG_SCF_FBW7_1	224:229	Mutation altering degron motif	0.5882
p.G228S	SIDM00463	T-Lymphoblastic Leukemia	GDSC	VTPHGT	DEG_SCF_FBW7_1	224:229	Mutation altering degron motif	0.5882
p.G228S	SIDM00362	Burkitt's Lymphoma	GDSC	VTPHGT	DEG_SCF_FBW7_1	224:229	Mutation altering degron motif	0.5882
p.G228S	SIDM00465	Ovarian Carcinoma	GDSC	VTPHGT	DEG_SCF_FBW7_1	224:229	Mutation altering degron motif	0.5882
p.G228S	SIDM00973	Melanoma	GDSC	VTPHGT	DEG_SCF_FBW7_1	224:229	Mutation altering degron motif	0.5882
p.G228S	SIDM00394	Cervical Carcinoma	GDSC	VTPHGT	DEG_SCF_FBW7_1	224:229	Mutation altering degron motif	0.5882
p.G228S	SIDM01196	Hepatocellular Carcinoma	GDSC	VTPHGT	DEG_SCF_FBW7_1	224:229	Mutation altering degron motif	0.5882
p.G228S	SIDM00599	Osteosarcoma	GDSC	VTPHGT	DEG_SCF_FBW7_1	224:229	Mutation altering degron motif	0.5882
p.G228S	SIDM00251	Gastric Carcinoma	GDSC	VTPHGT	DEG_SCF_FBW7_1	224:229	Mutation altering degron motif	0.5882
p.G228S	SIDM00290	Gastric Carcinoma	GDSC	VTPHGT	DEG_SCF_FBW7_1	224:229	Mutation altering degron motif	0.5882
p.G228S	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	VTPHGT	DEG_SCF_FBW7_1	224:229	Mutation altering degron motif	0.5882
p.G228S	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	VTPHGT	DEG_SCF_FBW7_1	224:229	Mutation altering degron motif	0.5882
p.G228S	SIDM00996	Thyroid Gland Carcinoma	GDSC	VTPHGT	DEG_SCF_FBW7_1	224:229	Mutation altering degron motif	0.5882
p.G228S	SIDM00338	Acute Myeloid Leukemia	GDSC	VTPHGT	DEG_SCF_FBW7_1	224:229	Mutation altering degron motif	0.5882
p.P245S	DO222868	MELA	ICGC	PPPY	ITCH	246:249	Mutation rewiring degron network	0.3056
p.P245S	DO222868	MELA	ICGC	PPEY	ITCH	251:254	Mutation rewiring degron network	0.1667
p.P305L	DO218773	ORCA	ICGC	PPPY	ITCH	295:298	Mutation rewiring degron network	0.1389
p.P245L	DO37432	SKCM	ICGC	PPPY	ITCH	246:249	Mutation rewiring degron network	0.3056
p.P245L	DO37432	SKCM	ICGC	PPEY	ITCH	251:254	Mutation rewiring degron network	0.1667
p.P258L	DO38404	STAD	ICGC	PPPY	ITCH	246:249	Mutation rewiring degron network	0.0833
p.P258L	DO38404	STAD	ICGC	PPEY	ITCH	251:254	Mutation rewiring degron network	0.2222
p.P295S	DO229257	THCA	ICGC	PPPY	ITCH	295:298	Mutation altering degron motif	0.6752
p.P248S	DO229250	THCA	ICGC	PPPY	ITCH	246:249	Mutation altering degron motif	0.5641
p.R215S	DO42424	UCEC	ICGC	VTPHGT	DEG_SCF_FBW7_1	224:229	Mutation rewiring degron network	0.0833
p.R215M	SIDM01951	Colorectal Carcinoma	GDSC	VTPHGT	DEG_SCF_FBW7_1	224:229	Mutation rewiring degron network	0.0833
p.S312R	SIDM00625	Other Sarcomas	GDSC	AESSS	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.1667
p.S312R	SIDM01203	Other Solid Cancers	GDSC	AESSS	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.1667
p.S312R	SIDM00127	Oral Cavity Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.1667
p.S312R	SIDM00484	Thyroid Gland Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.1667
p.S312R	SIDM00631	Breast Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.1667
p.S312R	SIDM00100	Mesothelioma	GDSC	AESSS	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.1667
p.P242T	SIDM00454	Rhabdomyosarcoma	GDSC	PPPY	ITCH	246:249	Mutation rewiring degron network	0.2222
p.P242T	SIDM00454	Rhabdomyosarcoma	GDSC	PPEY	ITCH	251:254	Mutation rewiring degron network	0.0833
p.P242T	ACH-000689	Sarcoma	CCLE	PPPY	ITCH	246:249	Mutation rewiring degron network	0.2222
p.P242T	ACH-000689	Sarcoma	CCLE	PPEY	ITCH	251:254	Mutation rewiring degron network	0.0833
p.P242T	RH-18	soft tissue	COSMIC	PPPY	ITCH	246:249	Mutation rewiring degron network	0.2222
p.P242T	RH-18	soft tissue	COSMIC	PPEY	ITCH	251:254	Mutation rewiring degron network	0.0833
p.H232Y	SIDM00002	Neuroblastoma	GDSC	VTPHGT	DEG_SCF_FBW7_1	224:229	Mutation rewiring degron network	0.25
p.H232Y	NBsusSR	autonomic ganglia	COSMIC	VTPHGT	DEG_SCF_FBW7_1	224:229	Mutation rewiring degron network	0.25
p.G323R	SIDM00686	Endometrial Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.3056
p.P251S	SIDM01100	Neuroblastoma	GDSC	PPEY	ITCH	251:254	Mutation altering degron motif	0.6752
p.P251S	ACH-000366	Neuroblastoma	CCLE	PPEY	ITCH	251:254	Mutation altering degron motif	0.6752
p.P251S	SK-N-DZ	autonomic ganglia	COSMIC	PPEY	ITCH	251:254	Mutation altering degron motif	0.6752
p.Q309H	SIDM00292	Small Cell Lung Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.0833
p.Q309H	LU-165	lung	COSMIC	AESSS	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.0833
p.R264G	SIDM00150	Colorectal Carcinoma	GDSC	PPEY	ITCH	251:254	Mutation rewiring degron network	0.0556
p.R264G	KM12	large intestine	COSMIC	PPEY	ITCH	251:254	Mutation rewiring degron network	0.0556
p.L342F	ACH-000410	Bone Cancer	CCLE	ADSTS	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.3056
p.P296T	ACH-000495	Kidney Cancer	CCLE	PPPY	ITCH	295:298	Mutation altering degron motif	0.7031
p.D338N	ACH-000594	Lung Cancer	CCLE	ADSTS	DEG_SPOP_SBC_1	337:341	Mutation altering degron motif	0.5821
p.V302M	ACH-000963	Colon/Colorectal Cancer	CCLE	PPPY	ITCH	295:298	Mutation rewiring degron network	0.2222
p.V302M	CCK-81	large intestine	COSMIC	PPPY	ITCH	295:298	Mutation rewiring degron network	0.2222
p.P336L	ACH-001389	Breast Cancer	CCLE	ADSTS	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.3056
p.P306L	ACH-002396	Bone Cancer	CCLE	PPPY	ITCH	295:298	Mutation rewiring degron network	0.1111
p.P306L	Sarc9371	bone	COSMIC	PPPY	ITCH	295:298	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FAM189A1

UniProt ID: O60320

Entrez ID: 23359

Protein name: Protein FAM189A1 (Transmembrane protein 228)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FAM189A1 in