DegronMD

Uniprot ID: O60320

Source protein: Protein FAM189A1

Source gene: FAM189A1

Class: DEG_SCF_FBW7_1

Location: 224:229

E3 ligase: FBXW7

DEGRON score: 0.8431

ASA_SCORE: 80.5667

COIL: 0.9128

CONS_SCORE: 0.4241

DSS_SCORE: 0.3978

HELIX: 0.0398

FCONS_SCORE: 0.9898

RIG_SCORE: 0.6863

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V230I	TCGA-ZB-A966	THYM	TCGA	VTPHGT	DEG_SCF_FBW7_1	0.3056
p.V230I	ACH-001518	Endometrial/Uterine Cancer	CCLE	VTPHGT	DEG_SCF_FBW7_1	0.3056
p.G228S	DO231075	LUSC	ICGC	VTPHGT	DEG_SCF_FBW7_1	0.5882
p.G228S	SIDM00463	T-Lymphoblastic Leukemia	GDSC	VTPHGT	DEG_SCF_FBW7_1	0.5882
p.G228S	SIDM00362	Burkitt's Lymphoma	GDSC	VTPHGT	DEG_SCF_FBW7_1	0.5882
p.G228S	SIDM00465	Ovarian Carcinoma	GDSC	VTPHGT	DEG_SCF_FBW7_1	0.5882
p.G228S	SIDM00973	Melanoma	GDSC	VTPHGT	DEG_SCF_FBW7_1	0.5882
p.G228S	SIDM00394	Cervical Carcinoma	GDSC	VTPHGT	DEG_SCF_FBW7_1	0.5882
p.G228S	SIDM01196	Hepatocellular Carcinoma	GDSC	VTPHGT	DEG_SCF_FBW7_1	0.5882
p.G228S	SIDM00599	Osteosarcoma	GDSC	VTPHGT	DEG_SCF_FBW7_1	0.5882
p.G228S	SIDM00251	Gastric Carcinoma	GDSC	VTPHGT	DEG_SCF_FBW7_1	0.5882
p.G228S	SIDM00290	Gastric Carcinoma	GDSC	VTPHGT	DEG_SCF_FBW7_1	0.5882
p.G228S	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	VTPHGT	DEG_SCF_FBW7_1	0.5882
p.G228S	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	VTPHGT	DEG_SCF_FBW7_1	0.5882
p.G228S	SIDM00996	Thyroid Gland Carcinoma	GDSC	VTPHGT	DEG_SCF_FBW7_1	0.5882
p.G228S	SIDM00338	Acute Myeloid Leukemia	GDSC	VTPHGT	DEG_SCF_FBW7_1	0.5882
p.R215S	DO42424	UCEC	ICGC	VTPHGT	DEG_SCF_FBW7_1	0.0833
p.R215M	SIDM01951	Colorectal Carcinoma	GDSC	VTPHGT	DEG_SCF_FBW7_1	0.0833
p.H232Y	SIDM00002	Neuroblastoma	GDSC	VTPHGT	DEG_SCF_FBW7_1	0.25
p.H232Y	NBsusSR	autonomic_ganglia	COSMIC	VTPHGT	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60320	Protein FAM189A1	DEG_SCF_FBW7_1	224:229	VTPHGT	FBXW7	0.8431	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons