DegronMD

Uniprot ID: Q6VMQ6

Source protein: Activating transcription factor 7-interacting protein 1

Source gene: ATF7IP

Class: DEG_SPOP_SBC_1

Location: 949:953

E3 ligase: SPOP

DEGRON score: 0.8767

ASA_SCORE: 82.52

COIL: 0.8234

CONS_SCORE: 0.4825

DSS_SCORE: 0.5061

HELIX: 0.167

FCONS_SCORE: 0.9621

RIG_SCORE: 0.6744

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G960S	TCGA-33-4583	LUSC	TCGA	ADSTS	DEG_SPOP_SBC_1	0.1389
p.G960C	TCGA-AP-A051	UCEC	TCGA	ADSTS	DEG_SPOP_SBC_1	0.1389
p.A942D	TCGA-XK-AAIW	PRAD	TCGA	ADSTS	DEG_SPOP_SBC_1	0.1389
p.G959S	DO27112	LUSC	ICGC	ADSTS	DEG_SPOP_SBC_1	0.1667
p.A941D	DO51407	PRAD	ICGC	ADSTS	DEG_SPOP_SBC_1	0.1111
p.G959C	DO42673	UCEC	ICGC	ADSTS	DEG_SPOP_SBC_1	0.1667
p.N942H	SIDM00578	Neuroblastoma	GDSC	ADSTS	DEG_SPOP_SBC_1	0.1389
p.N942H	NB1	autonomic_ganglia	COSMIC	ADSTS	DEG_SPOP_SBC_1	0.1389
p.I948T	SIDM00933	Breast Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	0.3056
p.I948T	CAL-51	breast	COSMIC	ADSTS	DEG_SPOP_SBC_1	0.3056
p.T944A	SIDM00092	Ovarian Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	0.1944
p.T944A	OVCAR-4	ovary	COSMIC	ADSTS	DEG_SPOP_SBC_1	0.1944
p.I940T	ACH-000856	Breast Cancer	CCLE	ADSTS	DEG_SPOP_SBC_1	0.0833
p.I940T	CAL-51	breast	COSMIC	ADSTS	DEG_SPOP_SBC_1	0.0833
p.G960D	ACH-002287	Colon/Colorectal Cancer	CCLE	ADSTS	DEG_SPOP_SBC_1	0.1389
p.G960D	NCI-H630	large_intestine	COSMIC	ADSTS	DEG_SPOP_SBC_1	0.1389
p.G959D	NCI-H630	large_intestine	COSMIC	ADSTS	DEG_SPOP_SBC_1	0.1667
p.I939T	CAL-51	breast	COSMIC	ADSTS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P25054	Adenomatous polyposis coli protein	DEG_SPOP_SBC_1	2795:2799	ADSTS	SPOP	0.9671	More...
Q27J81	Inverted formin-2	DEG_SPOP_SBC_1	1145:1149	ADSTS	SPOP	0.9983	More...
Q5VUA4	Zinc finger protein 318	DEG_SPOP_SBC_1	515:519	ADSTS	SPOP	0.9834	More...
Q6VMQ6	Activating transcription factor 7-interacting protein 1	DEG_SPOP_SBC_1	949:953	ADSTS	SPOP	0.8767	More...
Q99684	Zinc finger protein Gfi-1	DEG_SPOP_SBC_1	38:42	ADSTS	SPOP	0.833	More...
Q9HBL0	Tensin-1	DEG_SPOP_SBC_1	1085:1089	ADSTS	SPOP	0.9906	More...
Q7Z2K8	G protein-regulated inducer of neurite outgrowth 1	DEG_SPOP_SBC_1	161:165	ADSTS	SPOP	0.9942	More...
Q9C0D7	Probable ribonuclease ZC3H12C	DEG_SPOP_SBC_1	476:480	ADSTS	SPOP	0.9991	More...
O60320	Protein FAM189A1	DEG_SPOP_SBC_1	337:341	ADSTS	SPOP	0.919	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons