DegronMD - Q27J81(INF2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E1144K	TCGA-A6-6781	COAD	TCGA	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.3056
p.E1144K	DO8447	COAD	ICGC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.3056
p.S1136F	TCGA-EB-A431	SKCM	TCGA	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation blocking phosphorylation signal	0.5278
p.S1136F	TCGA-W3-AA1V	SKCM	TCGA	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation blocking phosphorylation signal	0.5278
p.S1136F	DO37671	SKCM	ICGC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation blocking phosphorylation signal	0.5278
p.S1136F	DO51276	SKCM	ICGC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation blocking phosphorylation signal	0.5278
p.S1158R	DO230343	COCA	ICGC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation blocking phosphorylation signal	0.5278
p.T1135M	DO229003	COCA	ICGC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.0556
p.T1135M	DO229005	COCA	ICGC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.0556
p.T1135M	SIDM00434	Plasma Cell Myeloma	GDSC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.0556
p.T1135M	SIDM00353	Other Sarcomas	GDSC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.0556
p.T1135M	SIDM00338	Acute Myeloid Leukemia	GDSC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.0556
p.T1135M	SIDM01020	Plasma Cell Myeloma	GDSC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.0556
p.T1135M	SIDM00577	Neuroblastoma	GDSC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.0556
p.T1135M	SIDM00547	Non-Small Cell Lung Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.0556
p.T1135M	SIDM00600	Thyroid Gland Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.0556
p.T1135M	SIDM00193	Colorectal Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.0556
p.T1135M	SIDM01145	Gastric Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.0556
p.T1135M	SIDM00571	Pancreatic Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.0556
p.T1135M	SIDM00530	Esophageal Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.0556
p.T1135M	SIDM00238	Ovarian Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.0556
p.T1135M	SIDM00568	Gastric Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.0556
p.T1135M	SIDM00562	Breast Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.0556
p.T1135M	SIDM00383	Gastric Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.0556
p.T1135M	SIDM00817	Kidney Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.0556
p.T1135M	SIDM00054	Pancreatic Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.0556
p.T1135M	SIDM00024	Non-Cancerous	GDSC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.0556
p.T1135M	SIDM00365	Small Cell Lung Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.0556
p.T1135M	SIDM00612	Glioma	GDSC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.0556
p.T1135M	SIDM00970	Bladder Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.0556
p.T1135M	SIDM00618	Hepatocellular Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.0556
p.T1135M	SIDM00561	Other Blood Cancers	GDSC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.0556
p.T1135M	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.0556
p.T1135M	SIDM00289	B-Lymphoblastic Leukemia	GDSC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.0556
p.T1135M	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.0556
p.T1135M	SIDM00503	Gastric Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.0556
p.T1135M	SIDM00604	Oral Cavity Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.0556
p.T1135M	SIDM01609	Endometrial Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.0556
p.T1135M	SIDM01464	Pancreatic Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.0556
p.T1135M	SIDM01767	Squamous Cell Lung Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.0556
p.T1135M	SIDM00500	Colorectal Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.0556
p.T1135M	SIDM01588	Endometrial Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.0556
p.T1135M	SIDM00162	Biliary Tract Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.0556
p.T1135M	SIDM01343	Gastric Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.0556
p.G1151V	DO229019	LICA	ICGC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.2778
p.A1143D	DO50672	ORCA	ICGC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.2778
p.A1155V	DO219881	SKCA	ICGC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.1667
p.E1150G	DO219881	SKCA	ICGC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.3056
p.V1140I	SIDM01619	Endometrial Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.1944
p.V1140I	ACH-000984	Endometrial/Uterine Cancer	CCLE	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

INF2

UniProt ID: Q27J81

Entrez ID: 64423

Protein name: Inverted formin-2 (HBEBP2-binding protein C)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for INF2 in