DegronMD - Q27J81(INF2)

FUNCTION: Severs actin filaments and accelerates their polymerization and depolymerization. {ECO:0000250}.

GO - Biological processes (BP): actin cytoskeleton organization [GO:0030036]; regulation of mitochondrial fission [GO:0090140]

GO - Molecular function (MF): actin binding [GO:0003779]; small GTPase binding [GO:0031267]

GO - Cellular component (CC): perinuclear region of cytoplasm [GO:0048471]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1136F	TCGA-EB-A431	SKCM	TCGA	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation blocking phosphorylation signal	0.5278
p.S1136F	TCGA-W3-AA1V	SKCM	TCGA	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation blocking phosphorylation signal	0.5278
p.S1136F	DO37671	SKCM	ICGC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation blocking phosphorylation signal	0.5278
p.S1136F	DO51276	SKCM	ICGC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation blocking phosphorylation signal	0.5278
p.S1158R	DO230343	COCA	ICGC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation blocking phosphorylation signal	0.5278
p.E1144K	TCGA-A6-6781	COAD	TCGA	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.3056
p.E1144K	DO8447	COAD	ICGC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.3056
p.E1150G	DO219881	SKCA	ICGC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.3056
p.G1151V	DO229019	LICA	ICGC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.2778
p.A1143D	DO50672	ORCA	ICGC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.2778
p.V1140I	SIDM01619	Endometrial Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.1944
p.V1140I	ACH-000984	Endometrial/Uterine Cancer	CCLE	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.1944
p.A1155V	DO219881	SKCA	ICGC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.1667
p.T1135M	DO229003	COCA	ICGC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.0556
p.T1135M	DO229005	COCA	ICGC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.0556
p.T1135M	SIDM00434	Plasma Cell Myeloma	GDSC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.0556
p.T1135M	SIDM00353	Other Sarcomas	GDSC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.0556
p.T1135M	SIDM00338	Acute Myeloid Leukemia	GDSC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.0556
p.T1135M	SIDM01020	Plasma Cell Myeloma	GDSC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.0556
p.T1135M	SIDM00577	Neuroblastoma	GDSC	ADSTS	DEG_SPOP_SBC_1	1145:1149	Mutation rewiring degron network	0.0556

Showing 1 to 20 of 50 entries

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Kaplan plot for INF2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

INF2

UniProt ID: Q27J81

Entrez ID: 64423

Protein name: Inverted formin-2 (HBEBP2-binding protein C)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for INF2 in