DegronMD

Uniprot ID: Q5VUA4

Source protein: Zinc finger protein 318

Source gene: ZNF318

Class: DEG_SPOP_SBC_1

Location: 515:519

E3 ligase: SPOP

DEGRON score: 0.9834

ASA_SCORE: 73.72

COIL: 0.782

CONS_SCORE: 0.3334

DSS_SCORE: 0.471

HELIX: 0.2036

FCONS_SCORE: 0.9723

RIG_SCORE: 0.6874

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R526C	TCGA-B7-5816	STAD	TCGA	ADSTS	DEG_SPOP_SBC_1	0.1389
p.R526C	DO38599	STAD	ICGC	ADSTS	DEG_SPOP_SBC_1	0.1389
p.R526C	SIDM00698	Small Cell Lung Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	0.1389
p.R526C	SIDM01228	Melanoma	GDSC	ADSTS	DEG_SPOP_SBC_1	0.1389
p.S517F	TCGA-C8-A8HP	BRCA	TCGA	ADSTS	DEG_SPOP_SBC_1	0.7982
p.S517F	DO219621	BRCA	ICGC	ADSTS	DEG_SPOP_SBC_1	0.7982
p.P529S	TCGA-CQ-5331	HNSC	TCGA	ADSTS	DEG_SPOP_SBC_1	0.0556
p.P529S	DO15495	HNSC	ICGC	ADSTS	DEG_SPOP_SBC_1	0.0556
p.R509C	TCGA-G3-A25Z	LIHC	TCGA	ADSTS	DEG_SPOP_SBC_1	0.1667
p.R509C	DO23078	LIHC	ICGC	ADSTS	DEG_SPOP_SBC_1	0.1667
p.R509C	DO27961	ORCA	ICGC	ADSTS	DEG_SPOP_SBC_1	0.1667
p.R509C	SIDM00761	Small Cell Lung Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	0.1667
p.R509C	ACH-000752	Lung Cancer	CCLE	ADSTS	DEG_SPOP_SBC_1	0.1667
p.R509C	NCI-H196	lung	COSMIC	ADSTS	DEG_SPOP_SBC_1	0.1667
p.L511M	DO229019	LICA	ICGC	ADSTS	DEG_SPOP_SBC_1	0.2222
p.S512R	DO229032	LICA	ICGC	ADSTS	DEG_SPOP_SBC_1	0.6944
p.S512N	DO232761	PBCA	ICGC	ADSTS	DEG_SPOP_SBC_1	0.6944
p.R509L	SIDM00399	Head and Neck Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	0.1667
p.R509L	SCC90	upper_aerodigestive_tract	COSMIC	ADSTS	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P25054	Adenomatous polyposis coli protein	DEG_SPOP_SBC_1	2795:2799	ADSTS	SPOP	0.9671	More...
Q27J81	Inverted formin-2	DEG_SPOP_SBC_1	1145:1149	ADSTS	SPOP	0.9983	More...
Q5VUA4	Zinc finger protein 318	DEG_SPOP_SBC_1	515:519	ADSTS	SPOP	0.9834	More...
Q6VMQ6	Activating transcription factor 7-interacting protein 1	DEG_SPOP_SBC_1	949:953	ADSTS	SPOP	0.8767	More...
Q99684	Zinc finger protein Gfi-1	DEG_SPOP_SBC_1	38:42	ADSTS	SPOP	0.833	More...
Q9HBL0	Tensin-1	DEG_SPOP_SBC_1	1085:1089	ADSTS	SPOP	0.9906	More...
Q7Z2K8	G protein-regulated inducer of neurite outgrowth 1	DEG_SPOP_SBC_1	161:165	ADSTS	SPOP	0.9942	More...
Q9C0D7	Probable ribonuclease ZC3H12C	DEG_SPOP_SBC_1	476:480	ADSTS	SPOP	0.9991	More...
O60320	Protein FAM189A1	DEG_SPOP_SBC_1	337:341	ADSTS	SPOP	0.919	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons