DegronMD - Q8IY33(MICALL2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A416P	TCGA-55-8510	LUAD	TCGA	PAWTPSAS	DEG_SCF_FBW7_1	404:411	Mutation rewiring degron network	0.1944
p.A416P	DO24339	LUAD	ICGC	PAWTPSAS	DEG_SCF_FBW7_1	404:411	Mutation rewiring degron network	0.1944
p.T723M	TCGA-60-2710	LUSC	TCGA	VRLHPD	LIG_APCC_ABBA_1	728:733	Mutation rewiring degron network	0.1944
p.T723M	DO26938	LUSC	ICGC	VRLHPD	LIG_APCC_ABBA_1	728:733	Mutation rewiring degron network	0.1944
p.T723M	ACH-001301	Neuroblastoma	CCLE	VRLHPD	LIG_APCC_ABBA_1	728:733	Mutation rewiring degron network	0.1944
p.A410T	TCGA-CK-4951	COAD	TCGA	PAWTPSAS	DEG_SCF_FBW7_1	404:411	Mutation altering degron motif	0.6028
p.A410T	TCGA-FI-A2D5	UCEC	TCGA	PAWTPSAS	DEG_SCF_FBW7_1	404:411	Mutation altering degron motif	0.6028
p.A410T	DO10582	COAD	ICGC	PAWTPSAS	DEG_SCF_FBW7_1	404:411	Mutation altering degron motif	0.6028
p.A410T	DO41331	UCEC	ICGC	PAWTPSAS	DEG_SCF_FBW7_1	404:411	Mutation altering degron motif	0.6028
p.A410T	ACH-000994	Endometrial/Uterine Cancer	CCLE	PAWTPSAS	DEG_SCF_FBW7_1	404:411	Mutation altering degron motif	0.6028
p.S529Y	TCGA-CR-7374	HNSC	TCGA	PLSTS	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.1667
p.S529Y	DO15334	HNSC	ICGC	PLSTS	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.1667
p.S512L	TCGA-D3-A1Q8	SKCM	TCGA	PLSTS	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.1389
p.S512L	DO37446	SKCM	ICGC	PLSTS	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.1389
p.S512L	SIDM01175	Other Sarcomas	GDSC	PLSTS	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.1389
p.S512L	ACH-002309	Sarcoma	CCLE	PLSTS	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.1389
p.S512L	SW684	soft tissue	COSMIC	PLSTS	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.1389
p.A416S	TCGA-ER-A19P	SKCM	TCGA	PAWTPSAS	DEG_SCF_FBW7_1	404:411	Mutation rewiring degron network	0.1944
p.A416S	DO47623	SKCM	ICGC	PAWTPSAS	DEG_SCF_FBW7_1	404:411	Mutation rewiring degron network	0.1944
p.A416S	SIDM00454	Rhabdomyosarcoma	GDSC	PAWTPSAS	DEG_SCF_FBW7_1	404:411	Mutation rewiring degron network	0.1944
p.W587C	TCGA-FD-A5BX	BLCA	TCGA	WRANLKPVD	DEG_APCC_DBOX_1	587:595	Mutation altering degron motif	0.5889
p.W587C	DO44079	BLCA	ICGC	WRANLKPVD	DEG_APCC_DBOX_1	587:595	Mutation altering degron motif	0.5889
p.Q527E	TCGA-GC-A3I6	BLCA	TCGA	PLSTS	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.2222
p.Q527E	DO844	BLCA	ICGC	PLSTS	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.2222
p.D733N	TCGA-VQ-A8PT	STAD	TCGA	VRLHPD	LIG_APCC_ABBA_1	728:733	Mutation altering degron motif	0.6932
p.D733N	DO233272	GACA	ICGC	VRLHPD	LIG_APCC_ABBA_1	728:733	Mutation altering degron motif	0.6932
p.D733N	DO51776	STAD	ICGC	VRLHPD	LIG_APCC_ABBA_1	728:733	Mutation altering degron motif	0.6932
p.D733N	SIDM00534	Colorectal Carcinoma	GDSC	VRLHPD	LIG_APCC_ABBA_1	728:733	Mutation altering degron motif	0.6932
p.A528T	TCGA-XK-AAIW	PRAD	TCGA	PLSTS	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.1944
p.A528T	DO51407	PRAD	ICGC	PLSTS	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.1944
p.S523N	DO223583	CLLE	ICGC	PLSTS	DEG_SPOP_SBC_1	519:523	Mutation altering degron motif	0.7069
p.V594M	DO44090	COAD	ICGC	WRANLKPVD	DEG_APCC_DBOX_1	587:595	Mutation altering degron motif	0.6097
p.P408Q	DO229029	LICA	ICGC	PAWTPSAS	DEG_SCF_FBW7_1	404:411	Mutation altering degron motif	0.7035
p.T522K	DO229028	LICA	ICGC	PLSTS	DEG_SPOP_SBC_1	519:523	Mutation altering degron motif	0.7306
p.D582E	DO229025	LICA	ICGC	WRANLKPVD	DEG_APCC_DBOX_1	587:595	Mutation rewiring degron network	0.1944
p.Q527K	DO229035	LICA	ICGC	PLSTS	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.2222
p.D595E	DO229009	LICA	ICGC	WRANLKPVD	DEG_APCC_DBOX_1	587:595	Mutation altering degron motif	0.5647
p.Q415K	DO229008	LICA	ICGC	PAWTPSAS	DEG_SCF_FBW7_1	404:411	Mutation rewiring degron network	0.2222
p.T725I	DO50759	LICA	ICGC	VRLHPD	LIG_APCC_ABBA_1	728:733	Mutation rewiring degron network	0.25
p.S726F	DO230979	LUSC	ICGC	VRLHPD	LIG_APCC_ABBA_1	728:733	Mutation blocking phosphorylation signal	0.7222
p.Q527H	DO222708	MELA	ICGC	PLSTS	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.2222
p.P599L	DO222843	MELA	ICGC	WRANLKPVD	DEG_APCC_DBOX_1	587:595	Mutation rewiring degron network	0.2222
p.T725S	DO46374	OV	ICGC	VRLHPD	LIG_APCC_ABBA_1	728:733	Mutation rewiring degron network	0.25
p.P584L	DO51481	PACA	ICGC	WRANLKPVD	DEG_APCC_DBOX_1	587:595	Mutation rewiring degron network	0.25
p.T413I	DO227596	PACA	ICGC	PAWTPSAS	DEG_SCF_FBW7_1	404:411	Mutation rewiring degron network	0.2778
p.A585T	DO232224	PBCA	ICGC	WRANLKPVD	DEG_APCC_DBOX_1	587:595	Mutation rewiring degron network	0.2778
p.R417Q	SIDM00216	Colorectal Carcinoma	GDSC	PAWTPSAS	DEG_SCF_FBW7_1	404:411	Mutation rewiring degron network	0.1667
p.R417Q	ACH-000989	Colon/Colorectal Cancer	CCLE	PAWTPSAS	DEG_SCF_FBW7_1	404:411	Mutation rewiring degron network	0.1667
p.R417Q	SNU-175	large intestine	COSMIC	PAWTPSAS	DEG_SCF_FBW7_1	404:411	Mutation rewiring degron network	0.1667
p.G583R	SIDM01037	Breast Carcinoma	GDSC	WRANLKPVD	DEG_APCC_DBOX_1	587:595	Mutation rewiring degron network	0.2222
p.G583R	SIDM00336	Melanoma	GDSC	WRANLKPVD	DEG_APCC_DBOX_1	587:595	Mutation rewiring degron network	0.2222
p.G583R	SIDM01652	Non-Cancerous	GDSC	WRANLKPVD	DEG_APCC_DBOX_1	587:595	Mutation rewiring degron network	0.2222
p.G583R	SIDM00187	Kidney Carcinoma	GDSC	WRANLKPVD	DEG_APCC_DBOX_1	587:595	Mutation rewiring degron network	0.2222
p.G583R	SIDM00680	Colorectal Carcinoma	GDSC	WRANLKPVD	DEG_APCC_DBOX_1	587:595	Mutation rewiring degron network	0.2222
p.G583R	SIDM01171	Glioblastoma	GDSC	WRANLKPVD	DEG_APCC_DBOX_1	587:595	Mutation rewiring degron network	0.2222
p.G583R	SIDM00728	Non-Small Cell Lung Carcinoma	GDSC	WRANLKPVD	DEG_APCC_DBOX_1	587:595	Mutation rewiring degron network	0.2222
p.G583R	SIDM00636	Non-Cancerous	GDSC	WRANLKPVD	DEG_APCC_DBOX_1	587:595	Mutation rewiring degron network	0.2222
p.G583R	SIDM00284	Melanoma	GDSC	WRANLKPVD	DEG_APCC_DBOX_1	587:595	Mutation rewiring degron network	0.2222
p.G583R	SIDM00853	Other Sarcomas	GDSC	WRANLKPVD	DEG_APCC_DBOX_1	587:595	Mutation rewiring degron network	0.2222
p.G583R	SIDM00758	Non-Small Cell Lung Carcinoma	GDSC	WRANLKPVD	DEG_APCC_DBOX_1	587:595	Mutation rewiring degron network	0.2222
p.G583R	SIDM00836	Colorectal Carcinoma	GDSC	WRANLKPVD	DEG_APCC_DBOX_1	587:595	Mutation rewiring degron network	0.2222
p.G583R	SIDM00709	Non-Small Cell Lung Carcinoma	GDSC	WRANLKPVD	DEG_APCC_DBOX_1	587:595	Mutation rewiring degron network	0.2222
p.G583R	SIDM00757	Non-Small Cell Lung Carcinoma	GDSC	WRANLKPVD	DEG_APCC_DBOX_1	587:595	Mutation rewiring degron network	0.2222
p.P519L	SIDM00773	Non-Cancerous	GDSC	PLSTS	DEG_SPOP_SBC_1	519:523	Mutation altering degron motif	0.7582
p.P519L	SIDM00454	Rhabdomyosarcoma	GDSC	PLSTS	DEG_SPOP_SBC_1	519:523	Mutation altering degron motif	0.7582
p.P519L	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	519:523	Mutation altering degron motif	0.7582
p.P519L	SIDM01112	Osteosarcoma	GDSC	PLSTS	DEG_SPOP_SBC_1	519:523	Mutation altering degron motif	0.7582
p.P519L	SIDM01099	Neuroblastoma	GDSC	PLSTS	DEG_SPOP_SBC_1	519:523	Mutation altering degron motif	0.7582
p.P519L	SIDM00694	Other Solid Cancers	GDSC	PLSTS	DEG_SPOP_SBC_1	519:523	Mutation altering degron motif	0.7582
p.P519L	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	519:523	Mutation altering degron motif	0.7582
p.P519L	SIDM00254	Neuroblastoma	GDSC	PLSTS	DEG_SPOP_SBC_1	519:523	Mutation altering degron motif	0.7582
p.P519L	SIDM00539	Esophageal Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	519:523	Mutation altering degron motif	0.7582
p.P519L	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	519:523	Mutation altering degron motif	0.7582
p.P519L	SIDM00774	Breast Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	519:523	Mutation altering degron motif	0.7582
p.P519L	SIDM01525	Acute Myeloid Leukemia	GDSC	PLSTS	DEG_SPOP_SBC_1	519:523	Mutation altering degron motif	0.7582
p.R417W	SIDM00222	Mesothelioma	GDSC	PAWTPSAS	DEG_SCF_FBW7_1	404:411	Mutation rewiring degron network	0.1667
p.R417W	SIDM00009	Acute Myeloid Leukemia	GDSC	PAWTPSAS	DEG_SCF_FBW7_1	404:411	Mutation rewiring degron network	0.1667
p.R417W	SIDM00940	Breast Carcinoma	GDSC	PAWTPSAS	DEG_SCF_FBW7_1	404:411	Mutation rewiring degron network	0.1667
p.N590K	SIDM01174	Cervical Carcinoma	GDSC	WRANLKPVD	DEG_APCC_DBOX_1	587:595	Mutation altering degron motif	0.5806
p.N590K	ACH-001402	Cervical Cancer	CCLE	WRANLKPVD	DEG_APCC_DBOX_1	587:595	Mutation altering degron motif	0.5806
p.N590K	SW756	cervix	COSMIC	WRANLKPVD	DEG_APCC_DBOX_1	587:595	Mutation altering degron motif	0.5806
p.T407I	SIDM01259	B-Lymphoblastic Leukemia	GDSC	PAWTPSAS	DEG_SCF_FBW7_1	404:411	Mutation altering degron motif	0.7078
p.T407I	ACH-001669	Leukemia	CCLE	PAWTPSAS	DEG_SCF_FBW7_1	404:411	Mutation altering degron motif	0.7078
p.T407I	ACH-002238	Leukemia	CCLE	PAWTPSAS	DEG_SCF_FBW7_1	404:411	Mutation altering degron motif	0.7078
p.T407I	GR-ST	haematopoietic and lymphoid tissue	COSMIC	PAWTPSAS	DEG_SCF_FBW7_1	404:411	Mutation altering degron motif	0.7078
p.S524T	SIDM01144	Gastric Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.3056
p.S524T	SIDM01194	Hepatocellular Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.3056
p.S524T	SIDM00192	Colorectal Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.3056
p.S524T	SIDM01569	Hepatocellular Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.3056
p.S524T	SNU-449	liver	COSMIC	PLSTS	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.3056
p.S524T	NCI-SNU-5	stomach	COSMIC	PLSTS	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.3056
p.T400M	SIDM01080	Oral Cavity Carcinoma	GDSC	PAWTPSAS	DEG_SCF_FBW7_1	404:411	Mutation rewiring degron network	0.2222
p.D402E	SIDM00210	Ovarian Carcinoma	GDSC	PAWTPSAS	DEG_SCF_FBW7_1	404:411	Mutation rewiring degron network	0.2778
p.D402E	A2780	ovary	COSMIC	PAWTPSAS	DEG_SCF_FBW7_1	404:411	Mutation rewiring degron network	0.2778
p.R602K	SIDM00482	Chronic Myelogenous Leukemia	GDSC	WRANLKPVD	DEG_APCC_DBOX_1	587:595	Mutation rewiring degron network	0.1389
p.R602K	RPMI-8866	haematopoietic and lymphoid tissue	COSMIC	WRANLKPVD	DEG_APCC_DBOX_1	587:595	Mutation rewiring degron network	0.1389
p.Y734H	SIDM00327	Hodgkin's Lymphoma	GDSC	VRLHPD	LIG_APCC_ABBA_1	728:733	Mutation blocking phosphorylation signal	0.75
p.Y734H	ACH-000754	Lymphoma	CCLE	VRLHPD	LIG_APCC_ABBA_1	728:733	Mutation blocking phosphorylation signal	0.75
p.T525I	SIDM00382	Glioblastoma	GDSC	PLSTS	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.2778
p.T525I	ACH-000609	Brain Cancer	CCLE	PLSTS	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.2778
p.T525I	SF126	central nervous system	COSMIC	PLSTS	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.2778
p.S521N	SIDM01617	Endometrial Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	519:523	Mutation altering degron motif	0.7069
p.S521N	ACH-000994	Endometrial/Uterine Cancer	CCLE	PLSTS	DEG_SPOP_SBC_1	519:523	Mutation altering degron motif	0.7069
p.D595N	ACH-001518	Endometrial/Uterine Cancer	CCLE	WRANLKPVD	DEG_APCC_DBOX_1	587:595	Mutation altering degron motif	0.5821
p.I740T	ACH-001610	Brain Cancer	CCLE	VRLHPD	LIG_APCC_ABBA_1	728:733	Mutation rewiring degron network	0.1389
p.S726C	ACH-001970	Metastasis	CCLE	VRLHPD	LIG_APCC_ABBA_1	728:733	Mutation blocking phosphorylation signal	0.7222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MICALL2

UniProt ID: Q8IY33

Entrez ID: 79778

Protein name: MICAL-like protein 2 (Junctional Rab13-binding protein) (Molecule interacting with CasL-like 2) (MICAL-L2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MICALL2 in