DegronMD

Uniprot ID: Q8IY33

Source protein: MICAL-like protein 2

Source gene: MICALL2

Class: DEG_SCF_FBW7_1

Location: 404:411

E3 ligase: FBXW7

DEGRON score: 0.9941

ASA_SCORE: 69.625

COIL: 0.8274

CONS_SCORE: 0.3814

DSS_SCORE: 0.6424

HELIX: 0.1051

FCONS_SCORE: 1.0863

RIG_SCORE: 0.6857

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A416P	TCGA-55-8510	LUAD	TCGA	PAWTPSAS	DEG_SCF_FBW7_1	0.1944
p.A416P	DO24339	LUAD	ICGC	PAWTPSAS	DEG_SCF_FBW7_1	0.1944
p.A410T	TCGA-CK-4951	COAD	TCGA	PAWTPSAS	DEG_SCF_FBW7_1	0.6028
p.A410T	TCGA-FI-A2D5	UCEC	TCGA	PAWTPSAS	DEG_SCF_FBW7_1	0.6028
p.A410T	DO10582	COAD	ICGC	PAWTPSAS	DEG_SCF_FBW7_1	0.6028
p.A410T	DO41331	UCEC	ICGC	PAWTPSAS	DEG_SCF_FBW7_1	0.6028
p.A410T	ACH-000994	Endometrial/Uterine Cancer	CCLE	PAWTPSAS	DEG_SCF_FBW7_1	0.6028
p.A416S	TCGA-ER-A19P	SKCM	TCGA	PAWTPSAS	DEG_SCF_FBW7_1	0.1944
p.A416S	DO47623	SKCM	ICGC	PAWTPSAS	DEG_SCF_FBW7_1	0.1944
p.A416S	SIDM00454	Rhabdomyosarcoma	GDSC	PAWTPSAS	DEG_SCF_FBW7_1	0.1944
p.P408Q	DO229029	LICA	ICGC	PAWTPSAS	DEG_SCF_FBW7_1	0.7035
p.Q415K	DO229008	LICA	ICGC	PAWTPSAS	DEG_SCF_FBW7_1	0.2222
p.T413I	DO227596	PACA	ICGC	PAWTPSAS	DEG_SCF_FBW7_1	0.2778
p.R417Q	SIDM00216	Colorectal Carcinoma	GDSC	PAWTPSAS	DEG_SCF_FBW7_1	0.1667
p.R417Q	ACH-000989	Colon/Colorectal Cancer	CCLE	PAWTPSAS	DEG_SCF_FBW7_1	0.1667
p.R417Q	SNU-175	large_intestine	COSMIC	PAWTPSAS	DEG_SCF_FBW7_1	0.1667
p.R417W	SIDM00222	Mesothelioma	GDSC	PAWTPSAS	DEG_SCF_FBW7_1	0.1667
p.R417W	SIDM00009	Acute Myeloid Leukemia	GDSC	PAWTPSAS	DEG_SCF_FBW7_1	0.1667
p.R417W	SIDM00940	Breast Carcinoma	GDSC	PAWTPSAS	DEG_SCF_FBW7_1	0.1667
p.T407I	SIDM01259	B-Lymphoblastic Leukemia	GDSC	PAWTPSAS	DEG_SCF_FBW7_1	0.7078
p.T407I	ACH-001669	Leukemia	CCLE	PAWTPSAS	DEG_SCF_FBW7_1	0.7078
p.T407I	ACH-002238	Leukemia	CCLE	PAWTPSAS	DEG_SCF_FBW7_1	0.7078
p.T407I	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	PAWTPSAS	DEG_SCF_FBW7_1	0.7078
p.T400M	SIDM01080	Oral Cavity Carcinoma	GDSC	PAWTPSAS	DEG_SCF_FBW7_1	0.2222
p.D402E	SIDM00210	Ovarian Carcinoma	GDSC	PAWTPSAS	DEG_SCF_FBW7_1	0.2778
p.D402E	A2780	ovary	COSMIC	PAWTPSAS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IY33	MICAL-like protein 2	DEG_SCF_FBW7_1	404:411	PAWTPSAS	FBXW7	0.9941	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PAWTPSAS

Degron related mutations and impact score

Drug responses associated with MICALL2 mutations

All proteins holding degron of PAWTPSAS