DegronMD

Uniprot ID: Q8IY33

Source protein: MICAL-like protein 2

Source gene: MICALL2

Class: DEG_APCC_DBOX_1

Location: 587:595

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9617

ASA_SCORE: 85.6889

COIL: 0.7407

CONS_SCORE: 0.3839

DSS_SCORE: 0.6753

HELIX: 0.2037

FCONS_SCORE: 1.1375

RIG_SCORE: 0.6969

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V594M	DO44090	COAD	ICGC	WRANLKPVD	DEG_APCC_DBOX_1	0.6097
p.W587C	TCGA-FD-A5BX	BLCA	TCGA	WRANLKPVD	DEG_APCC_DBOX_1	0.5889
p.W587C	DO44079	BLCA	ICGC	WRANLKPVD	DEG_APCC_DBOX_1	0.5889
p.D595N	ACH-001518	Endometrial/Uterine Cancer	CCLE	WRANLKPVD	DEG_APCC_DBOX_1	0.5821
p.N590K	SIDM01174	Cervical Carcinoma	GDSC	WRANLKPVD	DEG_APCC_DBOX_1	0.5806
p.N590K	ACH-001402	Cervical Cancer	CCLE	WRANLKPVD	DEG_APCC_DBOX_1	0.5806
p.N590K	SW756	cervix	COSMIC	WRANLKPVD	DEG_APCC_DBOX_1	0.5806
p.D595E	DO229009	LICA	ICGC	WRANLKPVD	DEG_APCC_DBOX_1	0.5647
p.A585T	DO232224	PBCA	ICGC	WRANLKPVD	DEG_APCC_DBOX_1	0.2778
p.P584L	DO51481	PACA	ICGC	WRANLKPVD	DEG_APCC_DBOX_1	0.25
p.P599L	DO222843	MELA	ICGC	WRANLKPVD	DEG_APCC_DBOX_1	0.2222
p.G583R	SIDM01037	Breast Carcinoma	GDSC	WRANLKPVD	DEG_APCC_DBOX_1	0.2222
p.G583R	SIDM00336	Melanoma	GDSC	WRANLKPVD	DEG_APCC_DBOX_1	0.2222
p.G583R	SIDM01652	Non-Cancerous	GDSC	WRANLKPVD	DEG_APCC_DBOX_1	0.2222
p.G583R	SIDM00187	Kidney Carcinoma	GDSC	WRANLKPVD	DEG_APCC_DBOX_1	0.2222
p.G583R	SIDM00680	Colorectal Carcinoma	GDSC	WRANLKPVD	DEG_APCC_DBOX_1	0.2222
p.G583R	SIDM01171	Glioblastoma	GDSC	WRANLKPVD	DEG_APCC_DBOX_1	0.2222
p.G583R	SIDM00728	Non-Small Cell Lung Carcinoma	GDSC	WRANLKPVD	DEG_APCC_DBOX_1	0.2222
p.G583R	SIDM00636	Non-Cancerous	GDSC	WRANLKPVD	DEG_APCC_DBOX_1	0.2222
p.G583R	SIDM00284	Melanoma	GDSC	WRANLKPVD	DEG_APCC_DBOX_1	0.2222
p.G583R	SIDM00853	Other Sarcomas	GDSC	WRANLKPVD	DEG_APCC_DBOX_1	0.2222
p.G583R	SIDM00758	Non-Small Cell Lung Carcinoma	GDSC	WRANLKPVD	DEG_APCC_DBOX_1	0.2222
p.G583R	SIDM00836	Colorectal Carcinoma	GDSC	WRANLKPVD	DEG_APCC_DBOX_1	0.2222
p.G583R	SIDM00709	Non-Small Cell Lung Carcinoma	GDSC	WRANLKPVD	DEG_APCC_DBOX_1	0.2222
p.G583R	SIDM00757	Non-Small Cell Lung Carcinoma	GDSC	WRANLKPVD	DEG_APCC_DBOX_1	0.2222

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Drug responses associated with MICALL2 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of WRANLKPVD

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IY33	MICAL-like protein 2	DEG_APCC_DBOX_1	587:595	WRANLKPVD	APC,CDC20,FZR1	0.9617	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: WRANLKPVD

Degron related mutations and impact score

Drug responses associated with MICALL2 mutations

All proteins holding degron of WRANLKPVD