DegronMD

Uniprot ID: Q8IY33

Source protein: MICAL-like protein 2

Source gene: MICALL2

Class: DEG_APCC_DBOX_1

Location: 587:595

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9617

ASA_SCORE: 85.6889

COIL: 0.7407

CONS_SCORE: 0.3839

DSS_SCORE: 0.6753

HELIX: 0.2037

FCONS_SCORE: 1.1375

RIG_SCORE: 0.6969

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W587C	TCGA-FD-A5BX	BLCA	TCGA	WRANLKPVD	DEG_APCC_DBOX_1	0.5889
p.W587C	DO44079	BLCA	ICGC	WRANLKPVD	DEG_APCC_DBOX_1	0.5889
p.V594M	DO44090	COAD	ICGC	WRANLKPVD	DEG_APCC_DBOX_1	0.6097
p.D582E	DO229025	LICA	ICGC	WRANLKPVD	DEG_APCC_DBOX_1	0.1944
p.D595E	DO229009	LICA	ICGC	WRANLKPVD	DEG_APCC_DBOX_1	0.5647
p.P599L	DO222843	MELA	ICGC	WRANLKPVD	DEG_APCC_DBOX_1	0.2222
p.P584L	DO51481	PACA	ICGC	WRANLKPVD	DEG_APCC_DBOX_1	0.25
p.A585T	DO232224	PBCA	ICGC	WRANLKPVD	DEG_APCC_DBOX_1	0.2778
p.G583R	SIDM01037	Breast Carcinoma	GDSC	WRANLKPVD	DEG_APCC_DBOX_1	0.2222
p.G583R	SIDM00336	Melanoma	GDSC	WRANLKPVD	DEG_APCC_DBOX_1	0.2222
p.G583R	SIDM01652	Non-Cancerous	GDSC	WRANLKPVD	DEG_APCC_DBOX_1	0.2222
p.G583R	SIDM00187	Kidney Carcinoma	GDSC	WRANLKPVD	DEG_APCC_DBOX_1	0.2222
p.G583R	SIDM00680	Colorectal Carcinoma	GDSC	WRANLKPVD	DEG_APCC_DBOX_1	0.2222
p.G583R	SIDM01171	Glioblastoma	GDSC	WRANLKPVD	DEG_APCC_DBOX_1	0.2222
p.G583R	SIDM00728	Non-Small Cell Lung Carcinoma	GDSC	WRANLKPVD	DEG_APCC_DBOX_1	0.2222
p.G583R	SIDM00636	Non-Cancerous	GDSC	WRANLKPVD	DEG_APCC_DBOX_1	0.2222
p.G583R	SIDM00284	Melanoma	GDSC	WRANLKPVD	DEG_APCC_DBOX_1	0.2222
p.G583R	SIDM00853	Other Sarcomas	GDSC	WRANLKPVD	DEG_APCC_DBOX_1	0.2222
p.G583R	SIDM00758	Non-Small Cell Lung Carcinoma	GDSC	WRANLKPVD	DEG_APCC_DBOX_1	0.2222
p.G583R	SIDM00836	Colorectal Carcinoma	GDSC	WRANLKPVD	DEG_APCC_DBOX_1	0.2222
p.G583R	SIDM00709	Non-Small Cell Lung Carcinoma	GDSC	WRANLKPVD	DEG_APCC_DBOX_1	0.2222
p.G583R	SIDM00757	Non-Small Cell Lung Carcinoma	GDSC	WRANLKPVD	DEG_APCC_DBOX_1	0.2222
p.N590K	SIDM01174	Cervical Carcinoma	GDSC	WRANLKPVD	DEG_APCC_DBOX_1	0.5806
p.N590K	ACH-001402	Cervical Cancer	CCLE	WRANLKPVD	DEG_APCC_DBOX_1	0.5806
p.N590K	SW756	cervix	COSMIC	WRANLKPVD	DEG_APCC_DBOX_1	0.5806
p.R602K	SIDM00482	Chronic Myelogenous Leukemia	GDSC	WRANLKPVD	DEG_APCC_DBOX_1	0.1389
p.R602K	RPMI-8866	haematopoietic_and_lymphoid_tissue	COSMIC	WRANLKPVD	DEG_APCC_DBOX_1	0.1389
p.D595N	ACH-001518	Endometrial/Uterine Cancer	CCLE	WRANLKPVD	DEG_APCC_DBOX_1	0.5821

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: WRANLKPVD

Degron related mutations and impact score

Drug responses associated with MICALL2 mutations

All proteins holding degron of WRANLKPVD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IY33	MICAL-like protein 2	DEG_APCC_DBOX_1	587:595	WRANLKPVD	APC,CDC20,FZR1	0.9617	More...