DegronMD

Uniprot ID: Q8IY33

Source protein: MICAL-like protein 2

Source gene: MICALL2

Class: LIG_APCC_ABBA_1

Location: 728:733

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9805

ASA_SCORE: 100.1667

COIL: 0.8853

CONS_SCORE: 0.4154

DSS_SCORE: 0.5472

HELIX: 0.0638

FCONS_SCORE: 0.967

RIG_SCORE: 0.7237

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T723M	TCGA-60-2710	LUSC	TCGA	VRLHPD	LIG_APCC_ABBA_1	0.1944
p.T723M	DO26938	LUSC	ICGC	VRLHPD	LIG_APCC_ABBA_1	0.1944
p.T723M	ACH-001301	Neuroblastoma	CCLE	VRLHPD	LIG_APCC_ABBA_1	0.1944
p.D733N	TCGA-VQ-A8PT	STAD	TCGA	VRLHPD	LIG_APCC_ABBA_1	0.6932
p.D733N	DO233272	GACA	ICGC	VRLHPD	LIG_APCC_ABBA_1	0.6932
p.D733N	DO51776	STAD	ICGC	VRLHPD	LIG_APCC_ABBA_1	0.6932
p.D733N	SIDM00534	Colorectal Carcinoma	GDSC	VRLHPD	LIG_APCC_ABBA_1	0.6932
p.T725I	DO50759	LICA	ICGC	VRLHPD	LIG_APCC_ABBA_1	0.25
p.S726F	DO230979	LUSC	ICGC	VRLHPD	LIG_APCC_ABBA_1	0.7222
p.T725S	DO46374	OV	ICGC	VRLHPD	LIG_APCC_ABBA_1	0.25
p.Y734H	SIDM00327	Hodgkin's Lymphoma	GDSC	VRLHPD	LIG_APCC_ABBA_1	0.75
p.Y734H	ACH-000754	Lymphoma	CCLE	VRLHPD	LIG_APCC_ABBA_1	0.75
p.I740T	ACH-001610	Brain Cancer	CCLE	VRLHPD	LIG_APCC_ABBA_1	0.1389
p.S726C	ACH-001970	Metastasis	CCLE	VRLHPD	LIG_APCC_ABBA_1	0.7222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IY33	MICAL-like protein 2	LIG_APCC_ABBA_1	728:733	VRLHPD	APC,CDC20,FZR1	0.9805	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons