DegronMD - Q86UK5(EVC2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.W83C	TCGA-29-2434	OV	TCGA	PESST	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.1111
p.I111T	TCGA-AA-3947	COAD	TCGA	PLSTS	DEG_SPOP_SBC_1	112:116	Mutation rewiring degron network	0.3056
p.I111T	DO8192	COAD	ICGC	PLSTS	DEG_SPOP_SBC_1	112:116	Mutation rewiring degron network	0.3056
p.D77E	TCGA-BK-A139	UCEC	TCGA	PESST	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.2778
p.D77E	TCGA-ZF-AA4V	BLCA	TCGA	PESST	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.2778
p.T115A	TCGA-BR-8485	STAD	TCGA	PLSTS	DEG_SPOP_SBC_1	112:116	Mutation altering degron motif	0.7139
p.T115A	DO47823	STAD	ICGC	PLSTS	DEG_SPOP_SBC_1	112:116	Mutation altering degron motif	0.7139
p.P79S	TCGA-CG-4466	STAD	TCGA	PESST	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.2222
p.P79S	DO38695	STAD	ICGC	PESST	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.2222
p.P112Q	TCGA-CM-6171	COAD	TCGA	PLSTS	DEG_SPOP_SBC_1	112:116	Mutation altering degron motif	0.7035
p.P112Q	DO8151	COAD	ICGC	PLSTS	DEG_SPOP_SBC_1	112:116	Mutation altering degron motif	0.7035
p.S116Y	TCGA-D1-A17Q	UCEC	TCGA	PLSTS	DEG_SPOP_SBC_1	112:116	Mutation altering degron motif	0.712
p.S116Y	DO41903	UCEC	ICGC	PLSTS	DEG_SPOP_SBC_1	112:116	Mutation altering degron motif	0.712
p.E108K	TCGA-DS-A1OB	CESC	TCGA	PLSTS	DEG_SPOP_SBC_1	112:116	Mutation rewiring degron network	0.2222
p.M107I	TCGA-DU-A7TB	LGG	TCGA	PLSTS	DEG_SPOP_SBC_1	112:116	Mutation rewiring degron network	0.1944
p.E63Q	DO48454	BLCA	ICGC	PESST	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.1111
p.G65R	DO477	BLCA	ICGC	PESST	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.1667
p.A117V	DO222967	BTCA	ICGC	PLSTS	DEG_SPOP_SBC_1	112:116	Mutation rewiring degron network	0.3056
p.A117V	SIDM00216	Colorectal Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	112:116	Mutation rewiring degron network	0.3056
p.A117V	ACH-000989	Colon/Colorectal Cancer	CCLE	PLSTS	DEG_SPOP_SBC_1	112:116	Mutation rewiring degron network	0.3056
p.A117V	SNU-175	large intestine	COSMIC	PLSTS	DEG_SPOP_SBC_1	112:116	Mutation rewiring degron network	0.3056
p.A69V	DO233259	GACA	ICGC	PESST	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.2778
p.Q76H	DO233618	GACA	ICGC	PESST	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.3056
p.P122T	DO228974	LICA	ICGC	PLSTS	DEG_SPOP_SBC_1	112:116	Mutation rewiring degron network	0.1667
p.L124F	DO50970	LICA	ICGC	PLSTS	DEG_SPOP_SBC_1	112:116	Mutation rewiring degron network	0.1111
p.G70R	DO50970	LICA	ICGC	PESST	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.3056
p.G85E	DO23112	LINC	ICGC	PESST	DEG_SPOP_SBC_1	71:75	Mutation substituting flanking lysine	0.1667
p.R69L	DO24359	LUAD	ICGC	PESST	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.2778
p.E77D	DO27811	MALY	ICGC	PESST	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.2778
p.P63S	DO220851	MELA	ICGC	PESST	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.1111
p.S116L	DO222843	MELA	ICGC	PLSTS	DEG_SPOP_SBC_1	112:116	Mutation altering degron motif	0.7667
p.S116L	NCI-H2347	lung	COSMIC	PLSTS	DEG_SPOP_SBC_1	112:116	Mutation altering degron motif	0.7667
p.T81A	DO51783	STAD	ICGC	PESST	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.1667
p.R69C	DO47903	STAD	ICGC	PESST	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.2778
p.N84H	DO41331	UCEC	ICGC	PESST	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.0833
p.L113F	SIDM00216	Colorectal Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	112:116	Mutation altering degron motif	0.587
p.L113F	SNU-175	large intestine	COSMIC	PLSTS	DEG_SPOP_SBC_1	112:116	Mutation altering degron motif	0.587
p.T115N	SIDM01183	Other Solid Cancers	GDSC	PLSTS	DEG_SPOP_SBC_1	112:116	Mutation altering degron motif	0.7055
p.T115N	ACH-001417	Lung Cancer	CCLE	PLSTS	DEG_SPOP_SBC_1	112:116	Mutation altering degron motif	0.7055
p.T115N	UMC-11	lung	COSMIC	PLSTS	DEG_SPOP_SBC_1	112:116	Mutation altering degron motif	0.7055
p.L103W	SIDM00549	B-Lymphoblastic Leukemia	GDSC	PLSTS	DEG_SPOP_SBC_1	112:116	Mutation rewiring degron network	0.0833
p.L103W	ACH-002267	Leukemia	CCLE	PLSTS	DEG_SPOP_SBC_1	112:116	Mutation rewiring degron network	0.0833
p.L103W	LC4-1	haematopoietic and lymphoid tissue	COSMIC	PLSTS	DEG_SPOP_SBC_1	112:116	Mutation rewiring degron network	0.0833
p.T115S	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	112:116	Mutation altering degron motif	0.6005
p.T115S	ACH-000717	Esophageal Cancer	CCLE	PLSTS	DEG_SPOP_SBC_1	112:116	Mutation altering degron motif	0.6005
p.T115S	COLO-680N	oesophagus	COSMIC	PLSTS	DEG_SPOP_SBC_1	112:116	Mutation altering degron motif	0.6005
p.G121W	SIDM01503	Small Cell Lung Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	112:116	Mutation rewiring degron network	0.1944
p.G121W	ACH-000844	Lung Cancer	CCLE	PLSTS	DEG_SPOP_SBC_1	112:116	Mutation rewiring degron network	0.1944
p.H125N	ACH-002023	Colon/Colorectal Cancer	CCLE	PLSTS	DEG_SPOP_SBC_1	112:116	Mutation rewiring degron network	0.0833
p.G72W	TE-9	oesophagus	COSMIC	PESST	DEG_SPOP_SBC_1	71:75	Mutation altering degron motif	0.7825
p.N119H	ACN	autonomic ganglia	COSMIC	PLSTS	DEG_SPOP_SBC_1	112:116	Mutation rewiring degron network	0.25
p.S121W	ZR-75-30	breast	COSMIC	PLSTS	DEG_SPOP_SBC_1	112:116	Mutation rewiring degron network	0.1944
p.R104H	SNU-1040	large intestine	COSMIC	PLSTS	DEG_SPOP_SBC_1	112:116	Mutation rewiring degron network	0.1111
p.G72V	TE-9	oesophagus	COSMIC	PESST	DEG_SPOP_SBC_1	71:75	Mutation altering degron motif	0.7532

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EVC2

UniProt ID: Q86UK5

Entrez ID: 132884

Protein name: Limbin (Ellis-van Creveld syndrome protein 2) (EVC2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EVC2 in