DegronMD - Q96HE9(PRR11)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V262I	TCGA-12-1089	GBM	TCGA	ARNPLVTVS	DEG_APCC_DBOX_1	255:263	Mutation altering degron motif	0.5965
p.V262I	TCGA-D1-A163	UCEC	TCGA	ARNPLVTVS	DEG_APCC_DBOX_1	255:263	Mutation altering degron motif	0.5965
p.V262I	DO233855	GACA	ICGC	ARNPLVTVS	DEG_APCC_DBOX_1	255:263	Mutation altering degron motif	0.5965
p.V262I	DO12346	GBM	ICGC	ARNPLVTVS	DEG_APCC_DBOX_1	255:263	Mutation altering degron motif	0.5965
p.V262I	DO50727	ORCA	ICGC	ARNPLVTVS	DEG_APCC_DBOX_1	255:263	Mutation altering degron motif	0.5965
p.V262I	DO41008	UCEC	ICGC	ARNPLVTVS	DEG_APCC_DBOX_1	255:263	Mutation altering degron motif	0.5965
p.V262I	SIDM01525	Acute Myeloid Leukemia	GDSC	ARNPLVTVS	DEG_APCC_DBOX_1	255:263	Mutation altering degron motif	0.5965
p.R280L	TCGA-22-5485	LUSC	TCGA	VLITPGKS	DEG_SCF_FBW7_1	284:291	Mutation rewiring degron network	0.2222
p.R280L	DO26553	LUSC	ICGC	VLITPGKS	DEG_SCF_FBW7_1	284:291	Mutation rewiring degron network	0.2222
p.S355N	TCGA-24-2293	OV	TCGA	PLSTS	DEG_SPOP_SBC_1	350:354	Mutation blocking phosphorylation signal	0.75
p.S355N	DO28005	OV	ICGC	PLSTS	DEG_SPOP_SBC_1	350:354	Mutation blocking phosphorylation signal	0.75
p.G167R	TCGA-3N-A9WC	SKCM	TCGA	VLITPGDS	DEG_SCF_FBW7_1	162:169	Mutation altering degron motif	0.6457
p.G167R	DO51234	SKCM	ICGC	VLITPGDS	DEG_SCF_FBW7_1	162:169	Mutation altering degron motif	0.6457
p.S354C	TCGA-55-6979	LUAD	TCGA	PLSTS	DEG_SPOP_SBC_1	350:354	Mutation altering degron motif	0.8652
p.S354C	DO24110	LUAD	ICGC	PLSTS	DEG_SPOP_SBC_1	350:354	Mutation altering degron motif	0.8652
p.S252L	TCGA-A5-A0G2	UCEC	TCGA	ARNPLVTVS	DEG_APCC_DBOX_1	255:263	Mutation blocking phosphorylation signal	0.6944
p.S252L	TCGA-EO-A22U	UCEC	TCGA	ARNPLVTVS	DEG_APCC_DBOX_1	255:263	Mutation blocking phosphorylation signal	0.6944
p.S252L	DO41235	UCEC	ICGC	ARNPLVTVS	DEG_APCC_DBOX_1	255:263	Mutation blocking phosphorylation signal	0.6944
p.S252L	DO43755	UCEC	ICGC	ARNPLVTVS	DEG_APCC_DBOX_1	255:263	Mutation blocking phosphorylation signal	0.6944
p.V158A	TCGA-AJ-A3EK	UCEC	TCGA	VLITPGDS	DEG_SCF_FBW7_1	162:169	Mutation rewiring degron network	0.2222
p.V158A	DO41584	UCEC	ICGC	VLITPGDS	DEG_SCF_FBW7_1	162:169	Mutation rewiring degron network	0.2222
p.A160V	TCGA-AX-A2HC	UCEC	TCGA	VLITPGDS	DEG_SCF_FBW7_1	162:169	Mutation rewiring degron network	0.2778
p.A160V	DO41572	UCEC	ICGC	VLITPGDS	DEG_SCF_FBW7_1	162:169	Mutation rewiring degron network	0.2778
p.S291C	TCGA-BR-8589	STAD	TCGA	VLITPGKS	DEG_SCF_FBW7_1	284:291	Mutation altering degron motif	0.8652
p.S291C	DO47813	STAD	ICGC	VLITPGKS	DEG_SCF_FBW7_1	284:291	Mutation altering degron motif	0.8652
p.P166L	TCGA-DA-A1I8	SKCM	TCGA	VLITPGDS	DEG_SCF_FBW7_1	162:169	Mutation altering degron motif	0.7582
p.P166L	DO37424	SKCM	ICGC	VLITPGDS	DEG_SCF_FBW7_1	162:169	Mutation altering degron motif	0.7582
p.L177V	TCGA-DG-A2KK	CESC	TCGA	VLITPGDS	DEG_SCF_FBW7_1	162:169	Mutation rewiring degron network	0.1111
p.L177V	DO51595	CESC	ICGC	VLITPGDS	DEG_SCF_FBW7_1	162:169	Mutation rewiring degron network	0.1111
p.P178S	TCGA-EY-A1GU	UCEC	TCGA	VLITPGDS	DEG_SCF_FBW7_1	162:169	Mutation rewiring degron network	0.0833
p.P178S	DO41518	UCEC	ICGC	VLITPGDS	DEG_SCF_FBW7_1	162:169	Mutation rewiring degron network	0.0833
p.I164M	TCGA-HZ-A4BH	PAAD	TCGA	VLITPGDS	DEG_SCF_FBW7_1	162:169	Mutation altering degron motif	0.6507
p.I164M	DO32814	PAAD	ICGC	VLITPGDS	DEG_SCF_FBW7_1	162:169	Mutation altering degron motif	0.6507
p.S169C	TCGA-MF-A522	LUSC	TCGA	VLITPGDS	DEG_SCF_FBW7_1	162:169	Mutation altering degron motif	0.8652
p.S169C	DO45526	LUSC	ICGC	VLITPGDS	DEG_SCF_FBW7_1	162:169	Mutation altering degron motif	0.8652
p.V162I	TCGA-XF-AAN1	BLCA	TCGA	VLITPGDS	DEG_SCF_FBW7_1	162:169	Mutation altering degron motif	0.5965
p.V162I	DO51942	BLCA	ICGC	VLITPGDS	DEG_SCF_FBW7_1	162:169	Mutation altering degron motif	0.5965
p.F337L	DO48566	BLCA	ICGC	LTPVMT	DEG_SCF_FBW7_1	325:330	Mutation rewiring degron network	0.1389
p.R335K	DO9812	COAD	ICGC	LTPVMT	DEG_SCF_FBW7_1	325:330	Mutation rewiring degron network	0.1944
p.R296Q	DO234462	ESAD	ICGC	VLITPGKS	DEG_SCF_FBW7_1	284:291	Mutation rewiring degron network	0.1944
p.R296W	DO233888	GACA	ICGC	VLITPGKS	DEG_SCF_FBW7_1	284:291	Mutation rewiring degron network	0.1944
p.R296W	DO13863	GBM	ICGC	VLITPGKS	DEG_SCF_FBW7_1	284:291	Mutation rewiring degron network	0.1944
p.R296W	DO36394	READ	ICGC	VLITPGKS	DEG_SCF_FBW7_1	284:291	Mutation rewiring degron network	0.1944
p.R296W	SIDM01233	Colorectal Carcinoma	GDSC	VLITPGKS	DEG_SCF_FBW7_1	284:291	Mutation rewiring degron network	0.1944
p.R296W	C2BBe1	large intestine	COSMIC	VLITPGKS	DEG_SCF_FBW7_1	284:291	Mutation rewiring degron network	0.1944
p.L265F	DO228941	LICA	ICGC	ARNPLVTVS	DEG_APCC_DBOX_1	255:263	Mutation rewiring degron network	0.2778
p.A255S	DO229035	LICA	ICGC	ARNPLVTVS	DEG_APCC_DBOX_1	255:263	Mutation altering degron motif	0.6477
p.V281F	DO229006	LICA	ICGC	VLITPGKS	DEG_SCF_FBW7_1	284:291	Mutation rewiring degron network	0.25
p.V268F	DO229009	LICA	ICGC	ARNPLVTVS	DEG_APCC_DBOX_1	255:263	Mutation rewiring degron network	0.1944
p.S291I	DO229008	LICA	ICGC	VLITPGKS	DEG_SCF_FBW7_1	284:291	Mutation altering degron motif	0.8453
p.V162F	DO23416	LINC	ICGC	VLITPGDS	DEG_SCF_FBW7_1	162:169	Mutation altering degron motif	0.7068
p.A332P	DO218945	LUAD	ICGC	LTPVMT	DEG_SCF_FBW7_1	325:330	Mutation rewiring degron network	0.2778
p.A332S	DO26662	LUSC	ICGC	LTPVMT	DEG_SCF_FBW7_1	325:330	Mutation rewiring degron network	0.2778
p.T287N	DO232761	PBCA	ICGC	VLITPGKS	DEG_SCF_FBW7_1	284:291	Mutation altering degron motif	0.8166
p.T330M	DO41584	UCEC	ICGC	LTPVMT	DEG_SCF_FBW7_1	325:330	Mutation altering degron motif	0.7423
p.T330M	SIDM00373	Endometrial Carcinoma	GDSC	LTPVMT	DEG_SCF_FBW7_1	325:330	Mutation altering degron motif	0.7423
p.R256Q	SIDM00433	T-Lymphoblastic Leukemia	GDSC	ARNPLVTVS	DEG_APCC_DBOX_1	255:263	Mutation altering degron motif	0.7329
p.R256Q	ACH-000795	Leukemia	CCLE	ARNPLVTVS	DEG_APCC_DBOX_1	255:263	Mutation altering degron motif	0.7329
p.R256Q	MOLT-13	haematopoietic and lymphoid tissue	COSMIC	ARNPLVTVS	DEG_APCC_DBOX_1	255:263	Mutation altering degron motif	0.7329
p.R280Q	SIDM00454	Rhabdomyosarcoma	GDSC	VLITPGKS	DEG_SCF_FBW7_1	284:291	Mutation rewiring degron network	0.2222
p.P178A	SIDM00782	Colorectal Carcinoma	GDSC	VLITPGDS	DEG_SCF_FBW7_1	162:169	Mutation rewiring degron network	0.0833
p.P178A	ACH-000381	Colon/Colorectal Cancer	CCLE	VLITPGDS	DEG_SCF_FBW7_1	162:169	Mutation rewiring degron network	0.0833
p.P178A	T84	large intestine	COSMIC	VLITPGDS	DEG_SCF_FBW7_1	162:169	Mutation rewiring degron network	0.0833
p.E245G	SIDM00817	Kidney Carcinoma	GDSC	ARNPLVTVS	DEG_APCC_DBOX_1	255:263	Mutation rewiring degron network	0.0556
p.E245G	RCC-JW	kidney	COSMIC	ARNPLVTVS	DEG_APCC_DBOX_1	255:263	Mutation rewiring degron network	0.0556
p.T269A	SIDM01146	Gastric Carcinoma	GDSC	ARNPLVTVS	DEG_APCC_DBOX_1	255:263	Mutation rewiring degron network	0.1667
p.T269A	ACH-000932	Gastric Cancer	CCLE	ARNPLVTVS	DEG_APCC_DBOX_1	255:263	Mutation rewiring degron network	0.1667
p.T269A	NCI-SNU-1	stomach	COSMIC	ARNPLVTVS	DEG_APCC_DBOX_1	255:263	Mutation rewiring degron network	0.1667
p.S291T	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	VLITPGKS	DEG_SCF_FBW7_1	284:291	Mutation altering degron motif	0.7116
p.S291T	ACH-000855	Esophageal Cancer	CCLE	VLITPGKS	DEG_SCF_FBW7_1	284:291	Mutation altering degron motif	0.7116
p.S291T	KYSE-150	oesophagus	COSMIC	VLITPGKS	DEG_SCF_FBW7_1	284:291	Mutation altering degron motif	0.7116
p.P159A	SIDM00783	Colorectal Carcinoma	GDSC	VLITPGDS	DEG_SCF_FBW7_1	162:169	Mutation rewiring degron network	0.25
p.P159A	HCT-116	large intestine	COSMIC	VLITPGDS	DEG_SCF_FBW7_1	162:169	Mutation rewiring degron network	0.25
p.S291G	SIDM00901	Endometrial Carcinoma	GDSC	VLITPGKS	DEG_SCF_FBW7_1	284:291	Mutation altering degron motif	0.8104
p.S291G	ACH-000940	Endometrial/Uterine Cancer	CCLE	VLITPGKS	DEG_SCF_FBW7_1	284:291	Mutation altering degron motif	0.8104
p.S291G	AN3-CA	endometrium	COSMIC	VLITPGKS	DEG_SCF_FBW7_1	284:291	Mutation altering degron motif	0.8104
p.M319V	SIDM01391	Neuroblastoma	GDSC	LTPVMT	DEG_SCF_FBW7_1	325:330	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PRR11

UniProt ID: Q96HE9

Entrez ID: 55771

Protein name: Proline-rich protein 11

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PRR11 in