DegronMD

Uniprot ID: Q96HE9

Source protein: Proline-rich protein 11

Source gene: PRR11

Class: DEG_SCF_FBW7_1

Location: 325:330

E3 ligase: FBXW7

DEGRON score: 0.9967

ASA_SCORE: 45.0333

COIL: 0.295

CONS_SCORE: 0.8348

DSS_SCORE: 0.6115

HELIX: 0.6872

FCONS_SCORE: 1.2497

RIG_SCORE: 0.7829

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F337L	DO48566	BLCA	ICGC	LTPVMT	DEG_SCF_FBW7_1	0.1389
p.R335K	DO9812	COAD	ICGC	LTPVMT	DEG_SCF_FBW7_1	0.1944
p.A332P	DO218945	LUAD	ICGC	LTPVMT	DEG_SCF_FBW7_1	0.2778
p.A332S	DO26662	LUSC	ICGC	LTPVMT	DEG_SCF_FBW7_1	0.2778
p.T330M	DO41584	UCEC	ICGC	LTPVMT	DEG_SCF_FBW7_1	0.7423
p.T330M	SIDM00373	Endometrial Carcinoma	GDSC	LTPVMT	DEG_SCF_FBW7_1	0.7423
p.M319V	SIDM01391	Neuroblastoma	GDSC	LTPVMT	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96HE9	Proline-rich protein 11	DEG_SCF_FBW7_1	325:330	LTPVMT	FBXW7	0.9967	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons