DegronMD

Uniprot ID: Q96HE9

Source protein: Proline-rich protein 11

Source gene: PRR11

Class: DEG_SCF_FBW7_1

Location: 162:169

E3 ligase: FBXW7

DEGRON score: 0.9994

ASA_SCORE: 79.8625

COIL: 0.9125

CONS_SCORE: 0.1979

DSS_SCORE: 0.3445

HELIX: 0.0224

FCONS_SCORE: 0.5985

RIG_SCORE: 0.7421

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G167R	TCGA-3N-A9WC	SKCM	TCGA	VLITPGDS	DEG_SCF_FBW7_1	0.6457
p.G167R	DO51234	SKCM	ICGC	VLITPGDS	DEG_SCF_FBW7_1	0.6457
p.V158A	TCGA-AJ-A3EK	UCEC	TCGA	VLITPGDS	DEG_SCF_FBW7_1	0.2222
p.V158A	DO41584	UCEC	ICGC	VLITPGDS	DEG_SCF_FBW7_1	0.2222
p.A160V	TCGA-AX-A2HC	UCEC	TCGA	VLITPGDS	DEG_SCF_FBW7_1	0.2778
p.A160V	DO41572	UCEC	ICGC	VLITPGDS	DEG_SCF_FBW7_1	0.2778
p.P166L	TCGA-DA-A1I8	SKCM	TCGA	VLITPGDS	DEG_SCF_FBW7_1	0.7582
p.P166L	DO37424	SKCM	ICGC	VLITPGDS	DEG_SCF_FBW7_1	0.7582
p.L177V	TCGA-DG-A2KK	CESC	TCGA	VLITPGDS	DEG_SCF_FBW7_1	0.1111
p.L177V	DO51595	CESC	ICGC	VLITPGDS	DEG_SCF_FBW7_1	0.1111
p.P178S	TCGA-EY-A1GU	UCEC	TCGA	VLITPGDS	DEG_SCF_FBW7_1	0.0833
p.P178S	DO41518	UCEC	ICGC	VLITPGDS	DEG_SCF_FBW7_1	0.0833
p.I164M	TCGA-HZ-A4BH	PAAD	TCGA	VLITPGDS	DEG_SCF_FBW7_1	0.6507
p.I164M	DO32814	PAAD	ICGC	VLITPGDS	DEG_SCF_FBW7_1	0.6507
p.S169C	TCGA-MF-A522	LUSC	TCGA	VLITPGDS	DEG_SCF_FBW7_1	0.8652
p.S169C	DO45526	LUSC	ICGC	VLITPGDS	DEG_SCF_FBW7_1	0.8652
p.V162I	TCGA-XF-AAN1	BLCA	TCGA	VLITPGDS	DEG_SCF_FBW7_1	0.5965
p.V162I	DO51942	BLCA	ICGC	VLITPGDS	DEG_SCF_FBW7_1	0.5965
p.V162F	DO23416	LINC	ICGC	VLITPGDS	DEG_SCF_FBW7_1	0.7068
p.P178A	SIDM00782	Colorectal Carcinoma	GDSC	VLITPGDS	DEG_SCF_FBW7_1	0.0833
p.P178A	ACH-000381	Colon/Colorectal Cancer	CCLE	VLITPGDS	DEG_SCF_FBW7_1	0.0833
p.P178A	T84	large_intestine	COSMIC	VLITPGDS	DEG_SCF_FBW7_1	0.0833
p.P159A	SIDM00783	Colorectal Carcinoma	GDSC	VLITPGDS	DEG_SCF_FBW7_1	0.25
p.P159A	HCT-116	large_intestine	COSMIC	VLITPGDS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96HE9	Proline-rich protein 11	DEG_SCF_FBW7_1	162:169	VLITPGDS	FBXW7	0.9994	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons