DegronMD

Uniprot ID: Q96HE9

Source protein: Proline-rich protein 11

Source gene: PRR11

Class: DEG_APCC_DBOX_1

Location: 255:263

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.67

ASA_SCORE: 58.6556

COIL: 0.6114

CONS_SCORE: 0.6836

DSS_SCORE: 0.4404

HELIX: 0.2468

FCONS_SCORE: 1.1584

RIG_SCORE: 0.7331

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V262I	TCGA-12-1089	GBM	TCGA	ARNPLVTVS	DEG_APCC_DBOX_1	0.5965
p.V262I	TCGA-D1-A163	UCEC	TCGA	ARNPLVTVS	DEG_APCC_DBOX_1	0.5965
p.V262I	DO233855	GACA	ICGC	ARNPLVTVS	DEG_APCC_DBOX_1	0.5965
p.V262I	DO12346	GBM	ICGC	ARNPLVTVS	DEG_APCC_DBOX_1	0.5965
p.V262I	DO50727	ORCA	ICGC	ARNPLVTVS	DEG_APCC_DBOX_1	0.5965
p.V262I	DO41008	UCEC	ICGC	ARNPLVTVS	DEG_APCC_DBOX_1	0.5965
p.V262I	SIDM01525	Acute Myeloid Leukemia	GDSC	ARNPLVTVS	DEG_APCC_DBOX_1	0.5965
p.S252L	TCGA-A5-A0G2	UCEC	TCGA	ARNPLVTVS	DEG_APCC_DBOX_1	0.6944
p.S252L	TCGA-EO-A22U	UCEC	TCGA	ARNPLVTVS	DEG_APCC_DBOX_1	0.6944
p.S252L	DO41235	UCEC	ICGC	ARNPLVTVS	DEG_APCC_DBOX_1	0.6944
p.S252L	DO43755	UCEC	ICGC	ARNPLVTVS	DEG_APCC_DBOX_1	0.6944
p.L265F	DO228941	LICA	ICGC	ARNPLVTVS	DEG_APCC_DBOX_1	0.2778
p.A255S	DO229035	LICA	ICGC	ARNPLVTVS	DEG_APCC_DBOX_1	0.6477
p.V268F	DO229009	LICA	ICGC	ARNPLVTVS	DEG_APCC_DBOX_1	0.1944
p.R256Q	SIDM00433	T-Lymphoblastic Leukemia	GDSC	ARNPLVTVS	DEG_APCC_DBOX_1	0.7329
p.R256Q	ACH-000795	Leukemia	CCLE	ARNPLVTVS	DEG_APCC_DBOX_1	0.7329
p.R256Q	MOLT-13	haematopoietic_and_lymphoid_tissue	COSMIC	ARNPLVTVS	DEG_APCC_DBOX_1	0.7329
p.E245G	SIDM00817	Kidney Carcinoma	GDSC	ARNPLVTVS	DEG_APCC_DBOX_1	0.0556
p.E245G	RCC-JW	kidney	COSMIC	ARNPLVTVS	DEG_APCC_DBOX_1	0.0556
p.T269A	SIDM01146	Gastric Carcinoma	GDSC	ARNPLVTVS	DEG_APCC_DBOX_1	0.1667
p.T269A	ACH-000932	Gastric Cancer	CCLE	ARNPLVTVS	DEG_APCC_DBOX_1	0.1667
p.T269A	NCI-SNU-1	stomach	COSMIC	ARNPLVTVS	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96HE9	Proline-rich protein 11	DEG_APCC_DBOX_1	255:263	ARNPLVTVS	APC,CDC20,FZR1	0.67	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons