DegronMD

Uniprot ID: Q96HE9

Source protein: Proline-rich protein 11

Source gene: PRR11

Class: DEG_SCF_FBW7_1

Location: 284:291

E3 ligase: FBXW7

DEGRON score: 0.9852

ASA_SCORE: 70.9

COIL: 0.6709

CONS_SCORE: 0.4969

DSS_SCORE: 0.3849

HELIX: 0.0504

FCONS_SCORE: 0.8951

RIG_SCORE: 0.793

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R280L	TCGA-22-5485	LUSC	TCGA	VLITPGKS	DEG_SCF_FBW7_1	0.2222
p.R280L	DO26553	LUSC	ICGC	VLITPGKS	DEG_SCF_FBW7_1	0.2222
p.S291C	TCGA-BR-8589	STAD	TCGA	VLITPGKS	DEG_SCF_FBW7_1	0.8652
p.S291C	DO47813	STAD	ICGC	VLITPGKS	DEG_SCF_FBW7_1	0.8652
p.R296Q	DO234462	ESAD	ICGC	VLITPGKS	DEG_SCF_FBW7_1	0.1944
p.R296W	DO233888	GACA	ICGC	VLITPGKS	DEG_SCF_FBW7_1	0.1944
p.R296W	DO13863	GBM	ICGC	VLITPGKS	DEG_SCF_FBW7_1	0.1944
p.R296W	DO36394	READ	ICGC	VLITPGKS	DEG_SCF_FBW7_1	0.1944
p.R296W	SIDM01233	Colorectal Carcinoma	GDSC	VLITPGKS	DEG_SCF_FBW7_1	0.1944
p.R296W	C2BBe1	large_intestine	COSMIC	VLITPGKS	DEG_SCF_FBW7_1	0.1944
p.V281F	DO229006	LICA	ICGC	VLITPGKS	DEG_SCF_FBW7_1	0.25
p.S291I	DO229008	LICA	ICGC	VLITPGKS	DEG_SCF_FBW7_1	0.8453
p.T287N	DO232761	PBCA	ICGC	VLITPGKS	DEG_SCF_FBW7_1	0.8166
p.R280Q	SIDM00454	Rhabdomyosarcoma	GDSC	VLITPGKS	DEG_SCF_FBW7_1	0.2222
p.S291T	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	VLITPGKS	DEG_SCF_FBW7_1	0.7116
p.S291T	ACH-000855	Esophageal Cancer	CCLE	VLITPGKS	DEG_SCF_FBW7_1	0.7116
p.S291T	KYSE-150	oesophagus	COSMIC	VLITPGKS	DEG_SCF_FBW7_1	0.7116
p.S291G	SIDM00901	Endometrial Carcinoma	GDSC	VLITPGKS	DEG_SCF_FBW7_1	0.8104
p.S291G	ACH-000940	Endometrial/Uterine Cancer	CCLE	VLITPGKS	DEG_SCF_FBW7_1	0.8104
p.S291G	AN3-CA	endometrium	COSMIC	VLITPGKS	DEG_SCF_FBW7_1	0.8104

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96HE9	Proline-rich protein 11	DEG_SCF_FBW7_1	284:291	VLITPGKS	FBXW7	0.9852	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons