DegronMD

Uniprot ID: Q6ZU67

Source protein: BEN domain-containing protein 4

Source gene: BEND4

Class: DEG_APCC_DBOX_1

Location: 449:457

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9681

ASA_SCORE: 78.9333

COIL: 0.6352

CONS_SCORE: 0.9553

DSS_SCORE: 0.4384

HELIX: 0.3434

FCONS_SCORE: 1.0203

RIG_SCORE: 0.7465

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R451C	TCGA-2W-A8YY	CESC	TCGA	ERRPLDPVK	DEG_APCC_DBOX_1	0.719
p.R451C	DO223732	CESC	ICGC	ERRPLDPVK	DEG_APCC_DBOX_1	0.719
p.R451C	DO227609	COCA	ICGC	ERRPLDPVK	DEG_APCC_DBOX_1	0.719
p.R451C	DO32908	PACA	ICGC	ERRPLDPVK	DEG_APCC_DBOX_1	0.719
p.P455S	TCGA-B5-A11E	UCEC	TCGA	ERRPLDPVK	DEG_APCC_DBOX_1	0.5641
p.P455S	DO41644	UCEC	ICGC	ERRPLDPVK	DEG_APCC_DBOX_1	0.5641
p.V441M	TCGA-CD-A4MG	STAD	TCGA	ERRPLDPVK	DEG_APCC_DBOX_1	0.1111
p.T459A	TCGA-DD-AAD6	LIHC	TCGA	ERRPLDPVK	DEG_APCC_DBOX_1	0.2778
p.T459A	DO52224	LIHC	ICGC	ERRPLDPVK	DEG_APCC_DBOX_1	0.2778
p.P452L	TCGA-ER-A19O	SKCM	TCGA	ERRPLDPVK	DEG_APCC_DBOX_1	0.6471
p.P452L	DO38063	SKCM	ICGC	ERRPLDPVK	DEG_APCC_DBOX_1	0.6471
p.E449K	TCGA-FW-A3R5	SKCM	TCGA	ERRPLDPVK	DEG_APCC_DBOX_1	0.591
p.E449K	DO37406	SKCM	ICGC	ERRPLDPVK	DEG_APCC_DBOX_1	0.591
p.S440L	TCGA-W3-AA1R	SKCM	TCGA	ERRPLDPVK	DEG_APCC_DBOX_1	0.5278
p.G444V	DO230342	COCA	ICGC	ERRPLDPVK	DEG_APCC_DBOX_1	0.1944
p.P452H	DO229031	LICA	ICGC	ERRPLDPVK	DEG_APCC_DBOX_1	0.6583
p.P452S	DO222824	MELA	ICGC	ERRPLDPVK	DEG_APCC_DBOX_1	0.5641
p.E445K	SIDM01096	Colorectal Carcinoma	GDSC	ERRPLDPVK	DEG_APCC_DBOX_1	0.2222
p.E445K	ACH-000400	Colon/Colorectal Cancer	CCLE	ERRPLDPVK	DEG_APCC_DBOX_1	0.2222
p.E445K	SK-CO-1	large_intestine	COSMIC	ERRPLDPVK	DEG_APCC_DBOX_1	0.2222
p.G447S	SIDM00683	Prostate Carcinoma	GDSC	ERRPLDPVK	DEG_APCC_DBOX_1	0.2778
p.G447S	ACH-000977	lymph_node	CCLE	ERRPLDPVK	DEG_APCC_DBOX_1	0.2778
p.G447S	LNCaP-Clone-FGC	prostate	COSMIC	ERRPLDPVK	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZU67	BEN domain-containing protein 4	DEG_APCC_DBOX_1	449:457	ERRPLDPVK	APC,CDC20,FZR1	0.9681	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons