DegronMD - Q6KC79(NIPBL)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1025I	TCGA-19-5956	GBM	TCGA	SRSSLKPIK	DEG_APCC_DBOX_1	1024:1032	Mutation altering degron motif	0.8102
p.R1025I	DO13863	GBM	ICGC	SRSSLKPIK	DEG_APCC_DBOX_1	1024:1032	Mutation altering degron motif	0.8102
p.E1021D	TCGA-38-4625	LUAD	TCGA	SRSSLKPIK	DEG_APCC_DBOX_1	1024:1032	Mutation rewiring degron network	0.25
p.E1021D	TCGA-A5-A0G2	UCEC	TCGA	SRSSLKPIK	DEG_APCC_DBOX_1	1024:1032	Mutation rewiring degron network	0.25
p.E1021D	DO23952	LUAD	ICGC	SRSSLKPIK	DEG_APCC_DBOX_1	1024:1032	Mutation rewiring degron network	0.25
p.E1021D	DO41235	UCEC	ICGC	SRSSLKPIK	DEG_APCC_DBOX_1	1024:1032	Mutation rewiring degron network	0.25
p.R1147Q	TCGA-55-6968	LUAD	TCGA	DSDMEDYSPPP	CBL_PTK	1153:1163	Mutation rewiring degron network	0.1667
p.R1147Q	TCGA-B5-A0JY	UCEC	TCGA	DSDMEDYSPPP	CBL_PTK	1153:1163	Mutation rewiring degron network	0.1667
p.R1147Q	DO23759	LUAD	ICGC	DSDMEDYSPPP	CBL_PTK	1153:1163	Mutation rewiring degron network	0.1667
p.R1147Q	DO43041	UCEC	ICGC	DSDMEDYSPPP	CBL_PTK	1153:1163	Mutation rewiring degron network	0.1667
p.S153N	TCGA-61-2012	OV	TCGA	PQTSS	DEG_SPOP_SBC_1	158:162	Mutation rewiring degron network	0.1944
p.D767N	TCGA-AG-A002	READ	TCGA	DSGKPST	DEG_SCF_TRCP1_1	767:773	Mutation altering degron motif	0.6932
p.D767N	DO234173	ESAD	ICGC	DSGKPST	DEG_SCF_TRCP1_1	767:773	Mutation altering degron motif	0.6932
p.K1032N	TCGA-AJ-A3EL	UCEC	TCGA	SRSSLKPIK	DEG_APCC_DBOX_1	1024:1032	Mutation altering degron motif	0.5806
p.K1032N	DO41542	UCEC	ICGC	SRSSLKPIK	DEG_APCC_DBOX_1	1024:1032	Mutation altering degron motif	0.5806
p.S148L	TCGA-BH-A0HA	BRCA	TCGA	PQTSS	DEG_SPOP_SBC_1	158:162	Mutation blocking phosphorylation signal	0.5
p.S148L	DO1658	BRCA	ICGC	PQTSS	DEG_SPOP_SBC_1	158:162	Mutation blocking phosphorylation signal	0.5
p.R766M	TCGA-BH-A0HA	BRCA	TCGA	DSGKPST	DEG_SCF_TRCP1_1	767:773	Mutation rewiring degron network	0.3056
p.R766M	DO1658	BRCA	ICGC	DSGKPST	DEG_SCF_TRCP1_1	767:773	Mutation rewiring degron network	0.3056
p.R1020G	TCGA-CN-5373	HNSC	TCGA	SRSSLKPIK	DEG_APCC_DBOX_1	1024:1032	Mutation rewiring degron network	0.2222
p.R1020G	DO16101	HNSC	ICGC	SRSSLKPIK	DEG_APCC_DBOX_1	1024:1032	Mutation rewiring degron network	0.2222
p.P1151Q	TCGA-D3-A1QA	SKCM	TCGA	DSDMEDYSPPP	CBL_PTK	1153:1163	Mutation rewiring degron network	0.2778
p.P1151Q	DO47469	SKCM	ICGC	DSDMEDYSPPP	CBL_PTK	1153:1163	Mutation rewiring degron network	0.2778
p.P1162H	TCGA-D3-A2JP	SKCM	TCGA	DSDMEDYSPPP	CBL_PTK	1153:1163	Mutation altering degron motif	0.6583
p.P1162H	DO47407	SKCM	ICGC	DSDMEDYSPPP	CBL_PTK	1153:1163	Mutation altering degron motif	0.6583
p.N171S	TCGA-D3-A3BZ	SKCM	TCGA	PQTSS	DEG_SPOP_SBC_1	158:162	Mutation rewiring degron network	0.0833
p.N171S	DO47513	SKCM	ICGC	PQTSS	DEG_SPOP_SBC_1	158:162	Mutation rewiring degron network	0.0833
p.S1026R	TCGA-EE-A29D	SKCM	TCGA	SRSSLKPIK	DEG_APCC_DBOX_1	1024:1032	Mutation altering degron motif	0.6316
p.S1026R	DO38123	SKCM	ICGC	SRSSLKPIK	DEG_APCC_DBOX_1	1024:1032	Mutation altering degron motif	0.6316
p.K1040E	TCGA-EO-A22X	UCEC	TCGA	SRSSLKPIK	DEG_APCC_DBOX_1	1024:1032	Mutation blocking ubiquitination signal	0.5556
p.K1040E	DO43907	UCEC	ICGC	SRSSLKPIK	DEG_APCC_DBOX_1	1024:1032	Mutation blocking ubiquitination signal	0.5556
p.R1145C	TCGA-FW-A3R5	SKCM	TCGA	DSDMEDYSPPP	CBL_PTK	1153:1163	Mutation rewiring degron network	0.1111
p.R1145C	DO37406	SKCM	ICGC	DSDMEDYSPPP	CBL_PTK	1153:1163	Mutation rewiring degron network	0.1111
p.V156A	TCGA-HU-8602	STAD	TCGA	PQTSS	DEG_SPOP_SBC_1	158:162	Mutation rewiring degron network	0.2778
p.V156A	DO47829	STAD	ICGC	PQTSS	DEG_SPOP_SBC_1	158:162	Mutation rewiring degron network	0.2778
p.P1151L	TCGA-KN-8428	KICH	TCGA	DSDMEDYSPPP	CBL_PTK	1153:1163	Mutation rewiring degron network	0.2778
p.P1151L	DO220484	KICH	ICGC	DSDMEDYSPPP	CBL_PTK	1153:1163	Mutation rewiring degron network	0.2778
p.P1163S	TCGA-TM-A7C3	LGG	TCGA	DSDMEDYSPPP	CBL_PTK	1153:1163	Mutation altering degron motif	0.6752
p.P1163S	DO50222	LGG	ICGC	DSDMEDYSPPP	CBL_PTK	1153:1163	Mutation altering degron motif	0.6752
p.P1163S	DO222843	MELA	ICGC	DSDMEDYSPPP	CBL_PTK	1153:1163	Mutation altering degron motif	0.6752
p.H149P	TCGA-W5-AA31	CHOL	TCGA	PQTSS	DEG_SPOP_SBC_1	158:162	Mutation rewiring degron network	0.0833
p.R154Q	TCGA-WS-AB45	COAD	TCGA	PQTSS	DEG_SPOP_SBC_1	158:162	Mutation rewiring degron network	0.2222
p.K1173N	TCGA-XF-A9SY	BLCA	TCGA	DSDMEDYSPPP	CBL_PTK	1153:1163	Mutation substituting flanking lysine	0.1667
p.K1173N	DO51918	BLCA	ICGC	DSDMEDYSPPP	CBL_PTK	1153:1163	Mutation substituting flanking lysine	0.1667
p.K1173N	DO224847	BRCA	ICGC	DSDMEDYSPPP	CBL_PTK	1153:1163	Mutation substituting flanking lysine	0.1667
p.K1173N	DO227473	BRCA	ICGC	DSDMEDYSPPP	CBL_PTK	1153:1163	Mutation substituting flanking lysine	0.1667
p.D1155N	TCGA-ZF-AA4X	BLCA	TCGA	DSDMEDYSPPP	CBL_PTK	1153:1163	Mutation altering degron motif	0.5821
p.D1155N	DO219091	BLCA	ICGC	DSDMEDYSPPP	CBL_PTK	1153:1163	Mutation altering degron motif	0.5821
p.S172I	DO233213	GACA	ICGC	PQTSS	DEG_SPOP_SBC_1	158:162	Mutation blocking phosphorylation signal	0.5
p.R1020K	DO11854	GBM	ICGC	SRSSLKPIK	DEG_APCC_DBOX_1	1024:1032	Mutation rewiring degron network	0.2222
p.S150T	DO224846	LAML	ICGC	PQTSS	DEG_SPOP_SBC_1	158:162	Mutation blocking phosphorylation signal	0.5556
p.R761M	DO228976	LICA	ICGC	DSGKPST	DEG_SCF_TRCP1_1	767:773	Mutation rewiring degron network	0.1667
p.R165I	DO228978	LICA	ICGC	PQTSS	DEG_SPOP_SBC_1	158:162	Mutation rewiring degron network	0.25
p.S150I	DO229035	LICA	ICGC	PQTSS	DEG_SPOP_SBC_1	158:162	Mutation blocking phosphorylation signal	0.5556
p.K776Q	DO50822	LIRI	ICGC	DSGKPST	DEG_SCF_TRCP1_1	767:773	Mutation substituting flanking lysine	0.3611
p.D1022G	SIDM00683	Prostate Carcinoma	GDSC	SRSSLKPIK	DEG_APCC_DBOX_1	1024:1032	Mutation rewiring degron network	0.2778
p.D1022G	ACH-000977	lymph node	CCLE	SRSSLKPIK	DEG_APCC_DBOX_1	1024:1032	Mutation rewiring degron network	0.2778
p.D1022G	LNCaP-Clone-FGC	prostate	COSMIC	SRSSLKPIK	DEG_APCC_DBOX_1	1024:1032	Mutation rewiring degron network	0.2778
p.P1161S	SIDM00231	Kidney Carcinoma	GDSC	DSDMEDYSPPP	CBL_PTK	1153:1163	Mutation altering degron motif	0.5641
p.P1161S	NCC010	kidney	COSMIC	DSDMEDYSPPP	CBL_PTK	1153:1163	Mutation altering degron motif	0.5641
p.L1016R	SIDM00193	Colorectal Carcinoma	GDSC	SRSSLKPIK	DEG_APCC_DBOX_1	1024:1032	Mutation rewiring degron network	0.1111
p.L1016R	ACH-000991	Colon/Colorectal Cancer	CCLE	SRSSLKPIK	DEG_APCC_DBOX_1	1024:1032	Mutation rewiring degron network	0.1111
p.L1016R	SNU-81	large intestine	COSMIC	SRSSLKPIK	DEG_APCC_DBOX_1	1024:1032	Mutation rewiring degron network	0.1111
p.P1151S	SIDM00990	Non-Small Cell Lung Carcinoma	GDSC	DSDMEDYSPPP	CBL_PTK	1153:1163	Mutation rewiring degron network	0.2778
p.P1151S	ACH-000603	Lung Cancer	CCLE	DSDMEDYSPPP	CBL_PTK	1153:1163	Mutation rewiring degron network	0.2778
p.P1151S	BEN	lung	COSMIC	DSDMEDYSPPP	CBL_PTK	1153:1163	Mutation rewiring degron network	0.2778
p.D1158H	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSDMEDYSPPP	CBL_PTK	1153:1163	Mutation altering degron motif	0.6577
p.D1158H	ACH-002215	Lymphoma	CCLE	DSDMEDYSPPP	CBL_PTK	1153:1163	Mutation altering degron motif	0.6577
p.D1158H	BC-3	haematopoietic and lymphoid tissue	COSMIC	DSDMEDYSPPP	CBL_PTK	1153:1163	Mutation altering degron motif	0.6577
p.P157L	SIDM00445	Esophageal Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	158:162	Mutation rewiring degron network	0.3056
p.P157L	ACH-002292	Esophageal Cancer	CCLE	PQTSS	DEG_SPOP_SBC_1	158:162	Mutation rewiring degron network	0.3056
p.P157L	OACp4C	oesophagus	COSMIC	PQTSS	DEG_SPOP_SBC_1	158:162	Mutation rewiring degron network	0.3056
p.R765K	SIDM01185	Other Solid Cancers	GDSC	DSGKPST	DEG_SCF_TRCP1_1	767:773	Mutation rewiring degron network	0.2778
p.R765K	SIDM01084	Osteosarcoma	GDSC	DSGKPST	DEG_SCF_TRCP1_1	767:773	Mutation rewiring degron network	0.2778
p.K1034E	SIDM00149	Melanoma	GDSC	SRSSLKPIK	DEG_APCC_DBOX_1	1024:1032	Mutation rewiring degron network	0.2778
p.K1034E	ACH-000750	Skin Cancer	CCLE	SRSSLKPIK	DEG_APCC_DBOX_1	1024:1032	Mutation rewiring degron network	0.2778
p.K1034E	LOXIMVI	skin	COSMIC	SRSSLKPIK	DEG_APCC_DBOX_1	1024:1032	Mutation rewiring degron network	0.2778
p.S1042N	SIDM00118	Colorectal Carcinoma	GDSC	SRSSLKPIK	DEG_APCC_DBOX_1	1024:1032	Mutation blocking phosphorylation signal	0.5
p.S1042N	ACH-001081	Colon/Colorectal Cancer	CCLE	SRSSLKPIK	DEG_APCC_DBOX_1	1024:1032	Mutation blocking phosphorylation signal	0.5
p.S1042N	HCC2998	large intestine	COSMIC	SRSSLKPIK	DEG_APCC_DBOX_1	1024:1032	Mutation blocking phosphorylation signal	0.5
p.M1156V	SIDM01692	T-Cell Non-Hodgkin's Lymphoma	GDSC	DSDMEDYSPPP	CBL_PTK	1153:1163	Mutation altering degron motif	0.6097
p.M1156V	ACH-000077	Lymphoma	CCLE	DSDMEDYSPPP	CBL_PTK	1153:1163	Mutation altering degron motif	0.6097
p.E1157Q	ACH-000868	Lung Cancer	CCLE	DSDMEDYSPPP	CBL_PTK	1153:1163	Mutation altering degron motif	0.5633
p.R1145H	ACH-001280	Sarcoma	CCLE	DSDMEDYSPPP	CBL_PTK	1153:1163	Mutation rewiring degron network	0.1111
p.M1172I	JSC-1	haematopoietic and lymphoid tissue	COSMIC	DSDMEDYSPPP	CBL_PTK	1153:1163	Mutation rewiring degron network	0.0833

Kaplan plot for NIPBL in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NIPBL

UniProt ID: Q6KC79

Entrez ID: 25836

Protein name: Nipped-B-like protein (Delangin) (SCC2 homolog)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NIPBL in