DegronMD

Uniprot ID: Q6KC79

Source protein: Nipped-B-like protein

Source gene: NIPBL

Class: DEG_SCF_TRCP1_1

Location: 767:773

E3 ligase: BTRC

DEGRON score: 0.9898

ASA_SCORE: 89.6

COIL: 0.9401

CONS_SCORE: 0.1914

DSS_SCORE: 0.8561

HELIX: 0.043

FCONS_SCORE: 0.989

RIG_SCORE: 0.4712

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D767N	TCGA-AG-A002	READ	TCGA	DSGKPST	DEG_SCF_TRCP1_1	0.6932
p.D767N	DO234173	ESAD	ICGC	DSGKPST	DEG_SCF_TRCP1_1	0.6932
p.R766M	TCGA-BH-A0HA	BRCA	TCGA	DSGKPST	DEG_SCF_TRCP1_1	0.3056
p.R766M	DO1658	BRCA	ICGC	DSGKPST	DEG_SCF_TRCP1_1	0.3056
p.R761M	DO228976	LICA	ICGC	DSGKPST	DEG_SCF_TRCP1_1	0.1667
p.K776Q	DO50822	LIRI	ICGC	DSGKPST	DEG_SCF_TRCP1_1	0.3611
p.R765K	SIDM01185	Other Solid Cancers	GDSC	DSGKPST	DEG_SCF_TRCP1_1	0.2778
p.R765K	SIDM01084	Osteosarcoma	GDSC	DSGKPST	DEG_SCF_TRCP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6KC79	Nipped-B-like protein	DEG_SCF_TRCP1_1	767:773	DSGKPST	BTRC	0.9898	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons