DegronMD

Uniprot ID: Q6KC79

Source protein: Nipped-B-like protein

Source gene: NIPBL

Class: CBL_PTK

Location: 1153:1163

E3 ligase: CBL

DEGRON score: 0.5778

ASA_SCORE: 91

COIL: 0.8804

CONS_SCORE: 0.2206

DSS_SCORE: 0.7005

HELIX: 0.1098

FCONS_SCORE: 0.9286

RIG_SCORE: 0.568

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1147Q	TCGA-55-6968	LUAD	TCGA	DSDMEDYSPPP	CBL_PTK	0.1667
p.R1147Q	TCGA-B5-A0JY	UCEC	TCGA	DSDMEDYSPPP	CBL_PTK	0.1667
p.R1147Q	DO23759	LUAD	ICGC	DSDMEDYSPPP	CBL_PTK	0.1667
p.R1147Q	DO43041	UCEC	ICGC	DSDMEDYSPPP	CBL_PTK	0.1667
p.P1151Q	TCGA-D3-A1QA	SKCM	TCGA	DSDMEDYSPPP	CBL_PTK	0.2778
p.P1151Q	DO47469	SKCM	ICGC	DSDMEDYSPPP	CBL_PTK	0.2778
p.P1162H	TCGA-D3-A2JP	SKCM	TCGA	DSDMEDYSPPP	CBL_PTK	0.6583
p.P1162H	DO47407	SKCM	ICGC	DSDMEDYSPPP	CBL_PTK	0.6583
p.R1145C	TCGA-FW-A3R5	SKCM	TCGA	DSDMEDYSPPP	CBL_PTK	0.1111
p.R1145C	DO37406	SKCM	ICGC	DSDMEDYSPPP	CBL_PTK	0.1111
p.P1151L	TCGA-KN-8428	KICH	TCGA	DSDMEDYSPPP	CBL_PTK	0.2778
p.P1151L	DO220484	KICH	ICGC	DSDMEDYSPPP	CBL_PTK	0.2778
p.P1163S	TCGA-TM-A7C3	LGG	TCGA	DSDMEDYSPPP	CBL_PTK	0.6752
p.P1163S	DO50222	LGG	ICGC	DSDMEDYSPPP	CBL_PTK	0.6752
p.P1163S	DO222843	MELA	ICGC	DSDMEDYSPPP	CBL_PTK	0.6752
p.K1173N	TCGA-XF-A9SY	BLCA	TCGA	DSDMEDYSPPP	CBL_PTK	0.1667
p.K1173N	DO51918	BLCA	ICGC	DSDMEDYSPPP	CBL_PTK	0.1667
p.K1173N	DO224847	BRCA	ICGC	DSDMEDYSPPP	CBL_PTK	0.1667
p.K1173N	DO227473	BRCA	ICGC	DSDMEDYSPPP	CBL_PTK	0.1667
p.D1155N	TCGA-ZF-AA4X	BLCA	TCGA	DSDMEDYSPPP	CBL_PTK	0.5821
p.D1155N	DO219091	BLCA	ICGC	DSDMEDYSPPP	CBL_PTK	0.5821
p.P1161S	SIDM00231	Kidney Carcinoma	GDSC	DSDMEDYSPPP	CBL_PTK	0.5641
p.P1161S	NCC010	kidney	COSMIC	DSDMEDYSPPP	CBL_PTK	0.5641
p.P1151S	SIDM00990	Non-Small Cell Lung Carcinoma	GDSC	DSDMEDYSPPP	CBL_PTK	0.2778
p.P1151S	ACH-000603	Lung Cancer	CCLE	DSDMEDYSPPP	CBL_PTK	0.2778
p.P1151S	BEN	lung	COSMIC	DSDMEDYSPPP	CBL_PTK	0.2778
p.D1158H	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSDMEDYSPPP	CBL_PTK	0.6577
p.D1158H	ACH-002215	Lymphoma	CCLE	DSDMEDYSPPP	CBL_PTK	0.6577
p.D1158H	BC-3	haematopoietic_and_lymphoid_tissue	COSMIC	DSDMEDYSPPP	CBL_PTK	0.6577
p.M1156V	SIDM01692	T-Cell Non-Hodgkin's Lymphoma	GDSC	DSDMEDYSPPP	CBL_PTK	0.6097
p.M1156V	ACH-000077	Lymphoma	CCLE	DSDMEDYSPPP	CBL_PTK	0.6097
p.E1157Q	ACH-000868	Lung Cancer	CCLE	DSDMEDYSPPP	CBL_PTK	0.5633
p.R1145H	ACH-001280	Sarcoma	CCLE	DSDMEDYSPPP	CBL_PTK	0.1111
p.M1172I	JSC-1	haematopoietic_and_lymphoid_tissue	COSMIC	DSDMEDYSPPP	CBL_PTK	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSDMEDYSPPP

Degron related mutations and impact score

Drug responses associated with NIPBL mutations

All proteins holding degron of DSDMEDYSPPP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6KC79	Nipped-B-like protein	CBL_PTK	1153:1163	DSDMEDYSPPP	CBL	0.5778	More...