DegronMD

Uniprot ID: Q6KC79

Source protein: Nipped-B-like protein

Source gene: NIPBL

Class: DEG_APCC_DBOX_1

Location: 1024:1032

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9841

ASA_SCORE: 110.7111

COIL: 0.8131

CONS_SCORE: 0.1872

DSS_SCORE: 0.6381

HELIX: 0.1697

FCONS_SCORE: 0.8601

RIG_SCORE: 0.6504

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1025I	TCGA-19-5956	GBM	TCGA	SRSSLKPIK	DEG_APCC_DBOX_1	0.8102
p.R1025I	DO13863	GBM	ICGC	SRSSLKPIK	DEG_APCC_DBOX_1	0.8102
p.E1021D	TCGA-38-4625	LUAD	TCGA	SRSSLKPIK	DEG_APCC_DBOX_1	0.25
p.E1021D	TCGA-A5-A0G2	UCEC	TCGA	SRSSLKPIK	DEG_APCC_DBOX_1	0.25
p.E1021D	DO23952	LUAD	ICGC	SRSSLKPIK	DEG_APCC_DBOX_1	0.25
p.E1021D	DO41235	UCEC	ICGC	SRSSLKPIK	DEG_APCC_DBOX_1	0.25
p.K1032N	TCGA-AJ-A3EL	UCEC	TCGA	SRSSLKPIK	DEG_APCC_DBOX_1	0.5806
p.K1032N	DO41542	UCEC	ICGC	SRSSLKPIK	DEG_APCC_DBOX_1	0.5806
p.R1020G	TCGA-CN-5373	HNSC	TCGA	SRSSLKPIK	DEG_APCC_DBOX_1	0.2222
p.R1020G	DO16101	HNSC	ICGC	SRSSLKPIK	DEG_APCC_DBOX_1	0.2222
p.S1026R	TCGA-EE-A29D	SKCM	TCGA	SRSSLKPIK	DEG_APCC_DBOX_1	0.6316
p.S1026R	DO38123	SKCM	ICGC	SRSSLKPIK	DEG_APCC_DBOX_1	0.6316
p.K1040E	TCGA-EO-A22X	UCEC	TCGA	SRSSLKPIK	DEG_APCC_DBOX_1	0.5556
p.K1040E	DO43907	UCEC	ICGC	SRSSLKPIK	DEG_APCC_DBOX_1	0.5556
p.R1020K	DO11854	GBM	ICGC	SRSSLKPIK	DEG_APCC_DBOX_1	0.2222
p.D1022G	SIDM00683	Prostate Carcinoma	GDSC	SRSSLKPIK	DEG_APCC_DBOX_1	0.2778
p.D1022G	ACH-000977	lymph_node	CCLE	SRSSLKPIK	DEG_APCC_DBOX_1	0.2778
p.D1022G	LNCaP-Clone-FGC	prostate	COSMIC	SRSSLKPIK	DEG_APCC_DBOX_1	0.2778
p.L1016R	SIDM00193	Colorectal Carcinoma	GDSC	SRSSLKPIK	DEG_APCC_DBOX_1	0.1111
p.L1016R	ACH-000991	Colon/Colorectal Cancer	CCLE	SRSSLKPIK	DEG_APCC_DBOX_1	0.1111
p.L1016R	SNU-81	large_intestine	COSMIC	SRSSLKPIK	DEG_APCC_DBOX_1	0.1111
p.K1034E	SIDM00149	Melanoma	GDSC	SRSSLKPIK	DEG_APCC_DBOX_1	0.2778
p.K1034E	ACH-000750	Skin Cancer	CCLE	SRSSLKPIK	DEG_APCC_DBOX_1	0.2778
p.K1034E	LOXIMVI	skin	COSMIC	SRSSLKPIK	DEG_APCC_DBOX_1	0.2778
p.S1042N	SIDM00118	Colorectal Carcinoma	GDSC	SRSSLKPIK	DEG_APCC_DBOX_1	0.5
p.S1042N	ACH-001081	Colon/Colorectal Cancer	CCLE	SRSSLKPIK	DEG_APCC_DBOX_1	0.5
p.S1042N	HCC2998	large_intestine	COSMIC	SRSSLKPIK	DEG_APCC_DBOX_1	0.5

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SRSSLKPIK

Degron related mutations and impact score

Drug responses associated with NIPBL mutations

All proteins holding degron of SRSSLKPIK

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6KC79	Nipped-B-like protein	DEG_APCC_DBOX_1	1024:1032	SRSSLKPIK	APC,CDC20,FZR1	0.9841	More...