DegronMD

Uniprot ID: Q6KC79

Source protein: Nipped-B-like protein

Source gene: NIPBL

Class: DEG_SPOP_SBC_1

Location: 158:162

E3 ligase: SPOP

DEGRON score: 0.9956

ASA_SCORE: 92.82

COIL: 0.9538

CONS_SCORE: 0.2733

DSS_SCORE: 0.7425

HELIX: 0.0286

FCONS_SCORE: 1.0873

RIG_SCORE: 0.5766

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S150T	DO224846	LAML	ICGC	PQTSS	DEG_SPOP_SBC_1	0.5556
p.S150I	DO229035	LICA	ICGC	PQTSS	DEG_SPOP_SBC_1	0.5556
p.S148L	TCGA-BH-A0HA	BRCA	TCGA	PQTSS	DEG_SPOP_SBC_1	0.5
p.S148L	DO1658	BRCA	ICGC	PQTSS	DEG_SPOP_SBC_1	0.5
p.S172I	DO233213	GACA	ICGC	PQTSS	DEG_SPOP_SBC_1	0.5
p.P157L	SIDM00445	Esophageal Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	0.3056
p.P157L	ACH-002292	Esophageal Cancer	CCLE	PQTSS	DEG_SPOP_SBC_1	0.3056
p.P157L	OACp4C	oesophagus	COSMIC	PQTSS	DEG_SPOP_SBC_1	0.3056
p.V156A	TCGA-HU-8602	STAD	TCGA	PQTSS	DEG_SPOP_SBC_1	0.2778
p.V156A	DO47829	STAD	ICGC	PQTSS	DEG_SPOP_SBC_1	0.2778
p.R165I	DO228978	LICA	ICGC	PQTSS	DEG_SPOP_SBC_1	0.25
p.R154Q	TCGA-WS-AB45	COAD	TCGA	PQTSS	DEG_SPOP_SBC_1	0.2222
p.S153N	TCGA-61-2012	OV	TCGA	PQTSS	DEG_SPOP_SBC_1	0.1944
p.N171S	TCGA-D3-A3BZ	SKCM	TCGA	PQTSS	DEG_SPOP_SBC_1	0.0833
p.N171S	DO47513	SKCM	ICGC	PQTSS	DEG_SPOP_SBC_1	0.0833
p.H149P	TCGA-W5-AA31	CHOL	TCGA	PQTSS	DEG_SPOP_SBC_1	0.0833

Showing 1 to 16 of 16 entries

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Drug responses associated with NIPBL mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PQTSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13023	A-kinase anchor protein 6	DEG_SPOP_SBC_1	2232:2236	PQTSS	SPOP	0.9624	More...
Q9P2G1	Ankyrin repeat and IBR domain-containing protein 1	DEG_SPOP_SBC_1	1076:1080	PQTSS	SPOP	0.9754	More...
Q96N21	AP-4 complex accessory subunit Tepsin	DEG_SPOP_SBC_1	500:504	PQTSS	SPOP	0.7617	More...
O95628	CCR4-NOT transcription complex subunit 4	DEG_SPOP_SBC_1	358:362	PQTSS	SPOP	0.8415	More...
P52564	Dual specificity mitogen-activated protein kinase kinase 6	DEG_SPOP_SBC_1	23:27	PQTSS	SPOP	0.9755	More...
Q14118	Dystroglycan 1	DEG_SPOP_SBC_1	146:150	PQTSS	SPOP	0.8524	More...
Q96RT1	Erbin	DEG_SPOP_SBC_1	1214:1218	PQTSS	SPOP	0.8905	More...
Q6Y7W6	GRB10-interacting GYF protein 2	DEG_SPOP_SBC_1	371:375	PQTSS	SPOP	0.9311	More...
Q09472	Histone acetyltransferase p300	DEG_SPOP_SBC_1	2342:2346	PQTSS	SPOP	0.8022	More...
Q14493	Histone RNA hairpin-binding protein	DEG_SPOP_SBC_1	224:228	PQTSS	SPOP	0.5108	More...
P41218	Myeloid cell nuclear differentiation antigen	DEG_SPOP_SBC_1	176:180	PQTSS	SPOP	0.9954	More...
Q6KC79	Nipped-B-like protein	DEG_SPOP_SBC_1	158:162	PQTSS	SPOP	0.9956	More...
P12270	Nucleoprotein TPR	DEG_SPOP_SBC_1	2173:2177	PQTSS	SPOP	0.9863	More...
Q6K0P9	Pyrin and HIN domain-containing protein 1	DEG_SPOP_SBC_1	179:183	PQTSS	SPOP	0.9899	More...
Q9UFD9	RIMS-binding protein 3A	DEG_SPOP_SBC_1	230:234	PQTSS	SPOP	0.6974	More...
A6NNM3	RIMS-binding protein 3B	DEG_SPOP_SBC_1	230:234	PQTSS	SPOP	0.6974	More...
A6NJZ7	RIMS-binding protein 3C	DEG_SPOP_SBC_1	230:234	PQTSS	SPOP	0.683	More...
Q8IYB3	Serine/arginine repetitive matrix protein 1	DEG_SPOP_SBC_1	691:695	PQTSS	SPOP	0.9405	More...
Q8IX01	SURP and G-patch domain-containing protein 2	DEG_SPOP_SBC_1	769:773	PQTSS	SPOP	0.9694	More...
P43694	Transcription factor GATA-4	DEG_SPOP_SBC_1	418:422	PQTSS	SPOP	0.8935	More...
Q9H2D6	TRIO and F-actin-binding protein	DEG_SPOP_SBC_1	947:951	PQTSS	SPOP	0.7773	More...

Showing 1 to 21 of 21 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PQTSS

Degron related mutations and impact score

Drug responses associated with NIPBL mutations

All proteins holding degron of PQTSS