DegronMD - Q6Y7W6(GIGYF2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E379D	TCGA-4Z-AA81	BLCA	TCGA	PQTSS	DEG_SPOP_SBC_1	371:375	Mutation rewiring degron network	0.2222
p.E379D	DO51868	BLCA	ICGC	PQTSS	DEG_SPOP_SBC_1	371:375	Mutation rewiring degron network	0.2222
p.N364S	TCGA-69-7980	LUAD	TCGA	PQTSS	DEG_SPOP_SBC_1	371:375	Mutation rewiring degron network	0.1389
p.N364S	DO23678	LUAD	ICGC	PQTSS	DEG_SPOP_SBC_1	371:375	Mutation rewiring degron network	0.1389
p.K372N	TCGA-A5-A0G2	UCEC	TCGA	PQTSS	DEG_SPOP_SBC_1	371:375	Mutation altering degron motif	0.6918
p.K372N	DO41235	UCEC	ICGC	PQTSS	DEG_SPOP_SBC_1	371:375	Mutation altering degron motif	0.6918
p.D371N	TCGA-AP-A056	UCEC	TCGA	PQTSS	DEG_SPOP_SBC_1	371:375	Mutation altering degron motif	0.6932
p.D371N	TCGA-EY-A1GX	UCEC	TCGA	PQTSS	DEG_SPOP_SBC_1	371:375	Mutation altering degron motif	0.6932
p.D371N	DO41967	UCEC	ICGC	PQTSS	DEG_SPOP_SBC_1	371:375	Mutation altering degron motif	0.6932
p.D371N	DO43971	UCEC	ICGC	PQTSS	DEG_SPOP_SBC_1	371:375	Mutation altering degron motif	0.6932
p.R90I	TCGA-BK-A6W3	UCEC	TCGA	LVPFTE	LIG_APCC_ABBA_1	81:86	Mutation rewiring degron network	0.2222
p.R90I	DO8730	COAD	ICGC	LVPFTE	LIG_APCC_ABBA_1	81:86	Mutation rewiring degron network	0.2222
p.R90I	DO50076	UCEC	ICGC	LVPFTE	LIG_APCC_ABBA_1	81:86	Mutation rewiring degron network	0.2222
p.P78Q	TCGA-DI-A1BU	UCEC	TCGA	LVPFTE	LIG_APCC_ABBA_1	81:86	Mutation rewiring degron network	0.25
p.P78Q	DO42023	UCEC	ICGC	LVPFTE	LIG_APCC_ABBA_1	81:86	Mutation rewiring degron network	0.25
p.S93F	TCGA-EE-A17X	SKCM	TCGA	LVPFTE	LIG_APCC_ABBA_1	81:86	Mutation rewiring degron network	0.1389
p.S93F	DO37931	SKCM	ICGC	LVPFTE	LIG_APCC_ABBA_1	81:86	Mutation rewiring degron network	0.1389
p.E915G	TCGA-F5-6814	READ	TCGA	PSSST	DEG_SPOP_SBC_1	924:928	Mutation rewiring degron network	0.0833
p.A80T	DO222404	BTCA	ICGC	LVPFTE	LIG_APCC_ABBA_1	81:86	Mutation rewiring degron network	0.3056
p.R919H	DO10819	EOPC	ICGC	PSSST	DEG_SPOP_SBC_1	924:928	Mutation rewiring degron network	0.1944
p.L928F	DO233213	GACA	ICGC	PSSST	DEG_SPOP_SBC_1	924:928	Mutation altering degron motif	0.6981
p.R929Q	DO233854	GACA	ICGC	PSSST	DEG_SPOP_SBC_1	924:928	Mutation rewiring degron network	0.3056
p.E916G	DO36556	READ	ICGC	PSSST	DEG_SPOP_SBC_1	924:928	Mutation rewiring degron network	0.1111
p.K375T	SIDM00193	Colorectal Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	371:375	Mutation altering degron motif	0.7306
p.K375T	SNU-81	large intestine	COSMIC	PQTSS	DEG_SPOP_SBC_1	371:375	Mutation altering degron motif	0.7306
p.E377Q	SIDM00797	Melanoma	GDSC	PQTSS	DEG_SPOP_SBC_1	371:375	Mutation blocking phosphorylation signal	0.7222
p.E377Q	A2058	skin	COSMIC	PQTSS	DEG_SPOP_SBC_1	371:375	Mutation blocking phosphorylation signal	0.7222
p.S361N	ACH-000422	Liver Cancer	CCLE	PQTSS	DEG_SPOP_SBC_1	371:375	Mutation rewiring degron network	0.0556
p.S361N	ACH-001664	Gastric Cancer	CCLE	PQTSS	DEG_SPOP_SBC_1	371:375	Mutation rewiring degron network	0.0556
p.S361N	SNU-475	liver	COSMIC	PQTSS	DEG_SPOP_SBC_1	371:375	Mutation rewiring degron network	0.0556
p.L76P	ACH-002026	Endometrial/Uterine Cancer	CCLE	LVPFTE	LIG_APCC_ABBA_1	81:86	Mutation rewiring degron network	0.1944
p.S367N	SNU-475	liver	COSMIC	PQTSS	DEG_SPOP_SBC_1	371:375	Mutation rewiring degron network	0.2222

Kaplan plot for GIGYF2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GIGYF2

UniProt ID: Q6Y7W6

Entrez ID: 26058

Protein name: GRB10-interacting GYF protein 2 (PERQ amino acid-rich with GYF domain-containing protein 2) (Trinucleotide repeat-containing gene 15 protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GIGYF2 in