DegronMD

Uniprot ID: Q6Y7W6

Source protein: GRB10-interacting GYF protein 2

Source gene: GIGYF2

Class: LIG_APCC_ABBA_1

Location: 81:86

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8533

ASA_SCORE: 61.5167

COIL: 0.7418

CONS_SCORE: 0.5633

DSS_SCORE: 0.3993

HELIX: 0.2197

FCONS_SCORE: 1.1426

RIG_SCORE: 0.8119

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R90I	TCGA-BK-A6W3	UCEC	TCGA	LVPFTE	LIG_APCC_ABBA_1	0.2222
p.R90I	DO8730	COAD	ICGC	LVPFTE	LIG_APCC_ABBA_1	0.2222
p.R90I	DO50076	UCEC	ICGC	LVPFTE	LIG_APCC_ABBA_1	0.2222
p.P78Q	TCGA-DI-A1BU	UCEC	TCGA	LVPFTE	LIG_APCC_ABBA_1	0.25
p.P78Q	DO42023	UCEC	ICGC	LVPFTE	LIG_APCC_ABBA_1	0.25
p.S93F	TCGA-EE-A17X	SKCM	TCGA	LVPFTE	LIG_APCC_ABBA_1	0.1389
p.S93F	DO37931	SKCM	ICGC	LVPFTE	LIG_APCC_ABBA_1	0.1389
p.A80T	DO222404	BTCA	ICGC	LVPFTE	LIG_APCC_ABBA_1	0.3056
p.L76P	ACH-002026	Endometrial/Uterine Cancer	CCLE	LVPFTE	LIG_APCC_ABBA_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons