DegronMD

Uniprot ID: P31629

Source protein: Transcription factor HIVEP2

Source gene: HIVEP2

Class: LIG_APCC_ABBA_1

Location: 247:252

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9358

ASA_SCORE: 72.85

COIL: 0.723

CONS_SCORE: 0.3229

DSS_SCORE: 0.1705

HELIX: 0.075

FCONS_SCORE: 0.4863

RIG_SCORE: 0.7931

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D259Y	TCGA-B0-4698	KIRC	TCGA	LVPFTE	LIG_APCC_ABBA_1	0.1389
p.D259Y	DO20368	KIRC	ICGC	LVPFTE	LIG_APCC_ABBA_1	0.1389
p.E261D	DO233918	GACA	ICGC	LVPFTE	LIG_APCC_ABBA_1	0.0833
p.A240D	DO229045	LICA	ICGC	LVPFTE	LIG_APCC_ABBA_1	0.1389
p.D259G	SIDM00223	Small Cell Lung Carcinoma	GDSC	LVPFTE	LIG_APCC_ABBA_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons