DegronMD - Q09472(EP300)

FUNCTION: Functions as histone acetyltransferase and regulates transcription via chromatin remodeling (PubMed:23415232, PubMed:23934153, PubMed:8945521). Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation (PubMed:23415232, PubMed:23934153, PubMed:8945521). Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Mediates acetylation of histone H3 at 'Lys-27' (H3K27ac) (PubMed:23911289). Also functions as acetyltransferase for non-histone targets, such as ALX1, HDAC1, PRMT1 or SIRT2 (PubMed:12929931, PubMed:16762839, PubMed:18722353). Acetylates 'Lys-131' of ALX1 and acts as its coactivator (PubMed:12929931). Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of p53/TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function (PubMed:18722353). Following DNA damage, forms a stress-responsive p53/TP53 coactivator complex with JMY which mediates p53/TP53 acetylation, thereby increasing p53/TP53-dependent transcription and apoptosis (PubMed:11511361, PubMed:15448695). Promotes chromatin acetylation in heat shock responsive HSP genes during the heat shock response (HSR), thereby stimulating HSR transcription (PubMed:18451878). Acetylates HDAC1 leading to its inactivation and modulation of transcription (PubMed:16762839). Acetylates 'Lys-247' of EGR2 (By similarity). Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2 (PubMed:12586840). Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement. Can also mediate transcriptional repression. Acetylates FOXO1 and enhances its transcriptional activity (PubMed:15890677). Acetylates BCL6 wich disrupts its ability to recruit histone deacetylases and hinders its transcriptional repressor activity (PubMed:12402037). Participates in CLOCK or NPAS2-regulated rhythmic gene transcription; exhibits a circadian association with CLOCK or NPAS2, correlating with increase in PER1/2 mRNA and histone H3 acetylation on the PER1/2 promoter (PubMed:14645221). Acetylates MTA1 at 'Lys-626' which is essential for its transcriptional coactivator activity (PubMed:16617102). Acetylates XBP1 isoform 2; acetylation increases protein stability of XBP1 isoform 2 and enhances its transcriptional activity (PubMed:20955178). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates MEF2D (PubMed:21030595). Acetylates and stabilizes ZBTB7B protein by antagonizing ubiquitin conjugation and degradation, this mechanism may be involved in CD4/CD8 lineage differentiation (PubMed:20810990). Acetylates GABPB1, impairing GABPB1 heterotetramerization and activity (By similarity). Acetylates PCK1 and promotes PCK1 anaplerotic activity (PubMed:30193097). Acetylates RXRA and RXRG (PubMed:17761950). Acetylates isoform M2 of PKM (PKM2), promoting its homodimerization and conversion into a protein kinase (PubMed:24120661). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA), butanoyl-CoA (butyryl-CoA), 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA), lactoyl-CoA or propanoyl-CoA (propionyl-CoA), and is able to mediate protein crotonylation, butyrylation, 2-hydroxyisobutyrylation, lactylation or propionylation, respectively (PubMed:17267393, PubMed:25818647, PubMed:29775581, PubMed:31645732). Acts as a histone crotonyltransferase; crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25818647). Histone crotonyltransferase activity is dependent on the concentration of (2E)-butenoyl-CoA (crotonyl-CoA) substrate and such activity is weak when (2E)-butenoyl-CoA (crotonyl-CoA) concentration is low (PubMed:25818647). Also acts as a histone butyryltransferase; butyrylation marks active promoters (PubMed:17267393). Catalyzes histone lactylation in macrophages by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription (PubMed:31645732). Acts as a protein-lysine 2-hydroxyisobutyryltransferase; regulates glycolysis by mediating 2-hydroxyisobutyrylation of glycolytic enzymes (PubMed:29775581). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000250|UniProtKB:B2RWS6, ECO:0000269|PubMed:10733570, ECO:0000269|PubMed:11430825, ECO:0000269|PubMed:11511361, ECO:0000269|PubMed:11701890, ECO:0000269|PubMed:12402037, ECO:0000269|PubMed:12586840, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:15186775, ECO:0000269|PubMed:15448695, ECO:0000269|PubMed:15890677, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:16762839, ECO:0000269|PubMed:17267393, ECO:0000269|PubMed:17761950, ECO:0000269|PubMed:18451878, ECO:0000269|PubMed:18722353, ECO:0000269|PubMed:18995842, ECO:0000269|PubMed:20810990, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:23415232, ECO:0000269|PubMed:23911289, ECO:0000269|PubMed:23934153, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:25818647, ECO:0000269|PubMed:29775581, ECO:0000269|PubMed:30193097, ECO:0000269|PubMed:31645732, ECO:0000269|PubMed:8945521, ECO:0000305|PubMed:20955178}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. {ECO:0000269|PubMed:10545121, ECO:0000269|PubMed:11080476}. View more >>

GO - Biological processes (BP): animal organ morphogenesis [GO:0009887]; apoptotic process [GO:0006915]; B cell differentiation [GO:0030183]; behavioral defense response [GO:0002209]; cell cycle [GO:0007049]; cellular response to UV [GO:0034644]; circadian rhythm [GO:0007623]; epigenetic maintenance of chromatin in transcription-competent conformation [GO:0045815]; face morphogenesis [GO:0060325]; fat cell differentiation [GO:0045444]; heart development [GO:0007507]; histone acetylation [GO:0016573]; histone H2B acetylation [GO:0043969]; histone H3-K56 acetylation [GO:0097043]; histone H4 acetylation [GO:0043967]; internal peptidyl-lysine acetylation [GO:0018393]; internal protein amino acid acetylation [GO:0006475]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; learning or memory [GO:0007611]; lung development [GO:0030324]; macrophage derived foam cell differentiation [GO:0010742]; megakaryocyte development [GO:0035855]; multicellular organism growth [GO:0035264]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; N-terminal peptidyl-lysine acetylation [GO:0018076]; peptidyl-lysine acetylation [GO:0018394]; peptidyl-lysine butyrylation [GO:0140067]; peptidyl-lysine crotonylation [GO:0140066]; peptidyl-lysine propionylation [GO:0061921]; platelet formation [GO:0030220]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of neuron projection development [GO:0010976]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of NIK/NF-kappaB signaling [GO:1901224]; positive regulation of protein binding [GO:0032092]; positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding [GO:1905636]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response [GO:0006990]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; protein acetylation [GO:0006473]; protein destabilization [GO:0031648]; protein stabilization [GO:0050821]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of autophagy [GO:0010506]; regulation of cellular response to heat [GO:1900034]; regulation of glycolytic process [GO:0006110]; regulation of mitochondrion organization [GO:0010821]; regulation of signal transduction by p53 class mediator [GO:1901796]; regulation of tubulin deacetylation [GO:0090043]; response to estrogen [GO:0043627]; response to hypoxia [GO:0001666]; skeletal muscle tissue development [GO:0007519]; somitogenesis [GO:0001756]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; swimming [GO:0036268]; thigmotaxis [GO:0001966] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S964Y	TCGA-06-5416	GBM	TCGA	PPSTS	DEG_SPOP_SBC_1	954:958	Mutation rewiring degron network	0.1667
p.S964Y	TCGA-19-5956	GBM	TCGA	PPSTS	DEG_SPOP_SBC_1	954:958	Mutation rewiring degron network	0.1667
p.S964Y	TCGA-B5-A1MR	UCEC	TCGA	PPSTS	DEG_SPOP_SBC_1	954:958	Mutation rewiring degron network	0.1667
p.S964Y	DO13863	GBM	ICGC	PPSTS	DEG_SPOP_SBC_1	954:958	Mutation rewiring degron network	0.1667
p.S964Y	DO10880	GBM	ICGC	PPSTS	DEG_SPOP_SBC_1	954:958	Mutation rewiring degron network	0.1667
p.S964Y	DO41758	UCEC	ICGC	PPSTS	DEG_SPOP_SBC_1	954:958	Mutation rewiring degron network	0.1667
p.P1910T	TCGA-18-3410	LUSC	TCGA	PPTPPQT	DEG_SCF_FBW7_1	1907:1913	Mutation altering degron motif	0.7031
p.P1910T	DO26456	LUSC	ICGC	PPTPPQT	DEG_SCF_FBW7_1	1907:1913	Mutation altering degron motif	0.7031
p.A1901V	TCGA-2G-AAGZ	TGCT	TCGA	PPTPPQT	DEG_SCF_FBW7_1	1907:1913	Mutation rewiring degron network	0.1667
p.A1901V	DO227901	PBCA	ICGC	PPTPPQT	DEG_SCF_FBW7_1	1907:1913	Mutation rewiring degron network	0.1667
p.S959N	TCGA-2H-A9GF	ESCA	TCGA	PPSTS	DEG_SPOP_SBC_1	954:958	Mutation rewiring degron network	0.3056
p.Y257D	TCGA-37-3783	LUSC	TCGA	NPYGSPYTQNP	CBL_PTK	251:261	Mutation altering degron motif	0.7325
p.Y257D	DO26734	LUSC	ICGC	NPYGSPYTQNP	CBL_PTK	251:261	Mutation altering degron motif	0.7325
p.Q1904P	TCGA-91-8499	LUAD	TCGA	PPTPPQT	DEG_SCF_FBW7_1	1907:1913	Mutation rewiring degron network	0.25
p.Q1904P	TCGA-EB-A41A	SKCM	TCGA	PPTPPQT	DEG_SCF_FBW7_1	1907:1913	Mutation rewiring degron network	0.25
p.Q1904P	DO45349	LUAD	ICGC	PPTPPQT	DEG_SCF_FBW7_1	1907:1913	Mutation rewiring degron network	0.25
p.Q1904P	DO37429	SKCM	ICGC	PPTPPQT	DEG_SCF_FBW7_1	1907:1913	Mutation rewiring degron network	0.25
p.Q1904P	SIDM00421	T-Cell Non-Hodgkin's Lymphoma	GDSC	PPTPPQT	DEG_SCF_FBW7_1	1907:1913	Mutation rewiring degron network	0.25
p.Q1904P	SIDM00230	Small Cell Lung Carcinoma	GDSC	PPTPPQT	DEG_SCF_FBW7_1	1907:1913	Mutation rewiring degron network	0.25
p.Q1904P	SUP-M2	haematopoietic and lymphoid tissue	COSMIC	PPTPPQT	DEG_SCF_FBW7_1	1907:1913	Mutation rewiring degron network	0.25
p.R838C	TCGA-AA-3715	COAD	TCGA	PTPHHT	DEG_SCF_FBW7_1	840:845	Mutation rewiring degron network	0.2778
p.R838C	DO8018	COAD	ICGC	PTPHHT	DEG_SCF_FBW7_1	840:845	Mutation rewiring degron network	0.2778
p.R838C	ACH-001061	Colon/Colorectal Cancer	CCLE	PTPHHT	DEG_SCF_FBW7_1	840:845	Mutation rewiring degron network	0.2778
p.P840T	TCGA-AG-A002	READ	TCGA	PTPHHT	DEG_SCF_FBW7_1	840:845	Mutation altering degron motif	0.7031
p.N249S	TCGA-AX-A0J0	UCEC	TCGA	NPYGSPYTQNP	CBL_PTK	251:261	Mutation rewiring degron network	0.2778
p.N249S	DO41133	UCEC	ICGC	NPYGSPYTQNP	CBL_PTK	251:261	Mutation rewiring degron network	0.2778
p.P930L	TCGA-B5-A11E	UCEC	TCGA	STAASVPTP	DEG_COP1_1	919:927	Mutation rewiring degron network	0.25
p.P930L	DO41644	UCEC	ICGC	STAASVPTP	DEG_COP1_1	919:927	Mutation rewiring degron network	0.25
p.T258I	TCGA-B5-A3FA	UCEC	TCGA	NPYGSPYTQNP	CBL_PTK	251:261	Mutation altering degron motif	0.7078
p.T258I	DO52402	UCEC	ICGC	NPYGSPYTQNP	CBL_PTK	251:261	Mutation altering degron motif	0.7078
p.E948K	TCGA-CV-6938	HNSC	TCGA	PPSTS	DEG_SPOP_SBC_1	954:958	Mutation rewiring degron network	0.1667
p.E948K	DO14462	HNSC	ICGC	PPSTS	DEG_SPOP_SBC_1	954:958	Mutation rewiring degron network	0.1667
p.S833L	TCGA-D8-A1XM	BRCA	TCGA	PTPHHT	DEG_SCF_FBW7_1	840:845	Mutation blocking phosphorylation signal	0.5833
p.S833L	DO2605	BRCA	ICGC	PTPHHT	DEG_SCF_FBW7_1	840:845	Mutation blocking phosphorylation signal	0.5833
p.S833L	SIDM02013	Colorectal Carcinoma	GDSC	PTPHHT	DEG_SCF_FBW7_1	840:845	Mutation blocking phosphorylation signal	0.5833
p.Q965E	TCGA-DD-AAE0	LIHC	TCGA	PPSTS	DEG_SPOP_SBC_1	954:958	Mutation rewiring degron network	0.1389
p.Q965E	DO52253	LIHC	ICGC	PPSTS	DEG_SPOP_SBC_1	954:958	Mutation rewiring degron network	0.1389
p.S958G	TCGA-DI-A1BU	UCEC	TCGA	PPSTS	DEG_SPOP_SBC_1	954:958	Mutation altering degron motif	0.6993
p.S958G	DO42023	UCEC	ICGC	PPSTS	DEG_SPOP_SBC_1	954:958	Mutation altering degron motif	0.6993
p.S958G	ACH-000710	Lung Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	954:958	Mutation altering degron motif	0.6993
p.P2347Q	TCGA-DU-7294	LGG	TCGA	PQTSS	DEG_SPOP_SBC_1	2342:2346	Mutation rewiring degron network	0.3056
p.P2347Q	DO22333	LGG	ICGC	PQTSS	DEG_SPOP_SBC_1	2342:2346	Mutation rewiring degron network	0.3056
p.P934T	TCGA-DZ-6133	KIRP	TCGA	STAASVPTP	DEG_COP1_1	919:927	Mutation rewiring degron network	0.1389
p.P934T	DO20762	KIRP	ICGC	STAASVPTP	DEG_COP1_1	919:927	Mutation rewiring degron network	0.1389
p.R915L	TCGA-E2-A1LK	BRCA	TCGA	STAASVPTP	DEG_COP1_1	919:927	Mutation rewiring degron network	0.2222
p.R915L	DO2719	BRCA	ICGC	STAASVPTP	DEG_COP1_1	919:927	Mutation rewiring degron network	0.2222
p.P555L	TCGA-EB-A5SE	SKCM	TCGA	SENASVPSL	DEG_COP1_1	545:553	Mutation rewiring degron network	0.2778
p.P555L	DO47295	SKCM	ICGC	SENASVPSL	DEG_COP1_1	545:553	Mutation rewiring degron network	0.2778
p.T1864S	TCGA-FB-AAQ6	PAAD	TCGA	PQTPQPT	DEG_SCF_FBW7_1	1866:1872	Mutation rewiring degron network	0.2778
p.T1864S	DO218971	PAAD	ICGC	PQTPQPT	DEG_SCF_FBW7_1	1866:1872	Mutation rewiring degron network	0.2778
p.P933L	TCGA-FR-A726	SKCM	TCGA	STAASVPTP	DEG_COP1_1	919:927	Mutation rewiring degron network	0.1667
p.P933L	DO48665	SKCM	ICGC	STAASVPTP	DEG_COP1_1	919:927	Mutation rewiring degron network	0.1667
p.P1877L	TCGA-FS-A1ZK	SKCM	TCGA	PQPTPPNS	DEG_SCF_FBW7_1	1875:1882	Mutation altering degron motif	0.6471
p.P1877L	DO37474	SKCM	ICGC	PQPTPPNS	DEG_SCF_FBW7_1	1875:1882	Mutation altering degron motif	0.6471
p.P1921L	TCGA-YG-AA3N	SKCM	TCGA	PPTPPQT	DEG_SCF_FBW7_1	1907:1913	Mutation rewiring degron network	0.1111
p.P1921L	DO51298	SKCM	ICGC	PPTPPQT	DEG_SCF_FBW7_1	1907:1913	Mutation rewiring degron network	0.1111
p.P927S	TCGA-Z2-A8RT	SKCM	TCGA	STAASVPTP	DEG_COP1_1	919:927	Mutation altering degron motif	0.6752
p.P927S	DO51301	SKCM	ICGC	STAASVPTP	DEG_COP1_1	919:927	Mutation altering degron motif	0.6752
p.N953S	DO222805	BTCA	ICGC	PPSTS	DEG_SPOP_SBC_1	954:958	Mutation rewiring degron network	0.3056
p.N538H	DO222718	COCA	ICGC	SENASVPSL	DEG_COP1_1	545:553	Mutation rewiring degron network	0.1389
p.R915C	DO223057	ESCA	ICGC	STAASVPTP	DEG_COP1_1	919:927	Mutation rewiring degron network	0.2222
p.R915C	DO45989	NBL	ICGC	STAASVPTP	DEG_COP1_1	919:927	Mutation rewiring degron network	0.2222
p.P562S	DO222440	ESCA	ICGC	SENASVPSL	DEG_COP1_1	545:553	Mutation rewiring degron network	0.0833
p.P881S	DO228896	LICA	ICGC	PTPPTT	DEG_SCF_FBW7_1	886:891	Mutation rewiring degron network	0.1944
p.V550L	DO229026	LICA	ICGC	SENASVPSL	DEG_COP1_1	545:553	Mutation altering degron motif	0.6765
p.V945L	DO229031	LICA	ICGC	PPSTS	DEG_SPOP_SBC_1	954:958	Mutation rewiring degron network	0.0833
p.S959I	DO229045	LICA	ICGC	PPSTS	DEG_SPOP_SBC_1	954:958	Mutation rewiring degron network	0.3056
p.P1880T	DO50940	LICA	ICGC	PQPTPPNS	DEG_SCF_FBW7_1	1875:1882	Mutation altering degron motif	0.5919
p.A944S	DO230937	LUSC	ICGC	PPSTS	DEG_SPOP_SBC_1	954:958	Mutation rewiring degron network	0.0556
p.A944S	DO224619	LUSC	ICGC	PPSTS	DEG_SPOP_SBC_1	954:958	Mutation rewiring degron network	0.0556
p.Q853R	DO51108	PRAD	ICGC	PTPHHT	DEG_SCF_FBW7_1	840:845	Mutation rewiring degron network	0.1111
p.P842S	SIDM01096	Colorectal Carcinoma	GDSC	PTPHHT	DEG_SCF_FBW7_1	840:845	Mutation altering degron motif	0.6752
p.P842S	ACH-000400	Colon/Colorectal Cancer	CCLE	PTPHHT	DEG_SCF_FBW7_1	840:845	Mutation altering degron motif	0.6752
p.P842S	SK-CO-1	large intestine	COSMIC	PTPHHT	DEG_SCF_FBW7_1	840:845	Mutation altering degron motif	0.6752
p.P888S	SIDM00705	Non-Cancerous	GDSC	PTPPTT	DEG_SCF_FBW7_1	886:891	Mutation altering degron motif	0.6752
p.P888S	SIDM00696	Non-Cancerous	GDSC	PTPPTT	DEG_SCF_FBW7_1	886:891	Mutation altering degron motif	0.6752
p.P888S	SIDM00772	Breast Carcinoma	GDSC	PTPPTT	DEG_SCF_FBW7_1	886:891	Mutation altering degron motif	0.6752
p.P888S	ACH-000755	Breast Cancer	CCLE	PTPPTT	DEG_SCF_FBW7_1	886:891	Mutation altering degron motif	0.6752
p.P888S	ACH-002369	Non-Cancerous	CCLE	PTPPTT	DEG_SCF_FBW7_1	886:891	Mutation altering degron motif	0.6752
p.P888S	ACH-002383	Non-Cancerous	CCLE	PTPPTT	DEG_SCF_FBW7_1	886:891	Mutation altering degron motif	0.6752
p.A966G	SIDM01219	Non-Small Cell Lung Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	954:958	Mutation rewiring degron network	0.1111
p.S1882N	SIDM00517	Head and Neck Carcinoma	GDSC	PQPTPPNS	DEG_SCF_FBW7_1	1875:1882	Mutation altering degron motif	0.7069
p.S1882N	ACH-002239	Head and Neck Cancer	CCLE	PQPTPPNS	DEG_SCF_FBW7_1	1875:1882	Mutation altering degron motif	0.7069
p.S1882N	H3118	upper aerodigestive tract	COSMIC	PQPTPPNS	DEG_SCF_FBW7_1	1875:1882	Mutation altering degron motif	0.7069
p.T891P	SIDM01112	Osteosarcoma	GDSC	PTPPTT	DEG_SCF_FBW7_1	886:891	Mutation altering degron motif	0.8142
p.T891P	ACH-000748	Bone Cancer	CCLE	PTPPTT	DEG_SCF_FBW7_1	886:891	Mutation altering degron motif	0.8142
p.T891P	SJSA-1	bone	COSMIC	PTPPTT	DEG_SCF_FBW7_1	886:891	Mutation altering degron motif	0.8142
p.A1902V	SIDM00333	Endometrial Carcinoma	GDSC	PPTPPQT	DEG_SCF_FBW7_1	1907:1913	Mutation rewiring degron network	0.1944
p.A1902V	ACH-000988	Endometrial/Uterine Cancer	CCLE	PPTPPQT	DEG_SCF_FBW7_1	1907:1913	Mutation rewiring degron network	0.1944
p.A1902V	MFE-319	endometrium	COSMIC	PPTPPQT	DEG_SCF_FBW7_1	1907:1913	Mutation rewiring degron network	0.1944
p.R883G	SIDM01100	Neuroblastoma	GDSC	PTPPTT	DEG_SCF_FBW7_1	886:891	Mutation rewiring degron network	0.25
p.R883G	ACH-000366	Neuroblastoma	CCLE	PTPPTT	DEG_SCF_FBW7_1	886:891	Mutation rewiring degron network	0.25
p.R883G	SK-N-DZ	autonomic ganglia	COSMIC	PTPPTT	DEG_SCF_FBW7_1	886:891	Mutation rewiring degron network	0.25
p.P1866L	SIDM00290	Gastric Carcinoma	GDSC	PQTPQPT	DEG_SCF_FBW7_1	1866:1872	Mutation altering degron motif	0.6471
p.P1866L	ACH-000847	Gastric Cancer	CCLE	PQTPQPT	DEG_SCF_FBW7_1	1866:1872	Mutation altering degron motif	0.6471
p.P1866L	ACH-002446	Gastric Cancer	CCLE	PQTPQPT	DEG_SCF_FBW7_1	1866:1872	Mutation altering degron motif	0.6471
p.P1866L	HGC-27	stomach	COSMIC	PQTPQPT	DEG_SCF_FBW7_1	1866:1872	Mutation altering degron motif	0.6471
p.Q1874E	SIDM00414	Bladder Carcinoma	GDSC	PQTPQPT	DEG_SCF_FBW7_1	1866:1872	Mutation rewiring degron network	0.2778
p.Q1874E	SIDM00414	Bladder Carcinoma	GDSC	PQPTPPNS	DEG_SCF_FBW7_1	1875:1882	Mutation rewiring degron network	0.3056
p.Q1874E	ACH-000545	Bladder Cancer	CCLE	PQTPQPT	DEG_SCF_FBW7_1	1866:1872	Mutation rewiring degron network	0.2778
p.Q1874E	ACH-000545	Bladder Cancer	CCLE	PQPTPPNS	DEG_SCF_FBW7_1	1875:1882	Mutation rewiring degron network	0.3056
p.Q1874E	VM-CUB-1	urinary tract	COSMIC	PQTPQPT	DEG_SCF_FBW7_1	1866:1872	Mutation rewiring degron network	0.2778
p.Q1874E	VM-CUB-1	urinary tract	COSMIC	PQPTPPNS	DEG_SCF_FBW7_1	1875:1882	Mutation rewiring degron network	0.3056
p.A2354T	SIDM00217	Colorectal Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	2342:2346	Mutation rewiring degron network	0.1111
p.A2354T	ACH-000999	Colon/Colorectal Cancer	CCLE	PQTSS	DEG_SPOP_SBC_1	2342:2346	Mutation rewiring degron network	0.1111
p.A2354T	SNU-1040	large intestine	COSMIC	PQTSS	DEG_SPOP_SBC_1	2342:2346	Mutation rewiring degron network	0.1111
p.M556V	SIDM01526	Mesothelioma	GDSC	SENASVPSL	DEG_COP1_1	545:553	Mutation rewiring degron network	0.25
p.G266A	SIDM01520	Oral Cavity Carcinoma	GDSC	NPYGSPYTQNP	CBL_PTK	251:261	Mutation rewiring degron network	0.1944
p.G266A	ACH-000503	Head and Neck Cancer	CCLE	NPYGSPYTQNP	CBL_PTK	251:261	Mutation rewiring degron network	0.1944
p.Q1898R	ACH-000990	Endometrial/Uterine Cancer	CCLE	PPTPPQT	DEG_SCF_FBW7_1	1907:1913	Mutation rewiring degron network	0.0833
p.T558K	ACH-002080	Neuroblastoma	CCLE	SENASVPSL	DEG_COP1_1	545:553	Mutation rewiring degron network	0.1944

Kaplan plot for EP300 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EP300

UniProt ID: Q09472

Entrez ID: 2033

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EP300 in