DegronMD

Uniprot ID: Q09472

Source protein: Histone acetyltransferase p300

Source gene: EP300

Class: DEG_SCF_FBW7_1

Location: 1907:1913

E3 ligase: FBXW7

DEGRON score: 0.993

ASA_SCORE: 99.6857

COIL: 0.9741

CONS_SCORE: 0.3525

DSS_SCORE: 0.8601

HELIX: 0.0111

FCONS_SCORE: 0.9783

RIG_SCORE: 0.5648

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1910T	TCGA-18-3410	LUSC	TCGA	PPTPPQT	DEG_SCF_FBW7_1	0.7031
p.P1910T	DO26456	LUSC	ICGC	PPTPPQT	DEG_SCF_FBW7_1	0.7031
p.A1901V	TCGA-2G-AAGZ	TGCT	TCGA	PPTPPQT	DEG_SCF_FBW7_1	0.1667
p.A1901V	DO227901	PBCA	ICGC	PPTPPQT	DEG_SCF_FBW7_1	0.1667
p.Q1904P	TCGA-91-8499	LUAD	TCGA	PPTPPQT	DEG_SCF_FBW7_1	0.25
p.Q1904P	TCGA-EB-A41A	SKCM	TCGA	PPTPPQT	DEG_SCF_FBW7_1	0.25
p.Q1904P	DO45349	LUAD	ICGC	PPTPPQT	DEG_SCF_FBW7_1	0.25
p.Q1904P	DO37429	SKCM	ICGC	PPTPPQT	DEG_SCF_FBW7_1	0.25
p.Q1904P	SIDM00421	T-Cell Non-Hodgkin's Lymphoma	GDSC	PPTPPQT	DEG_SCF_FBW7_1	0.25
p.Q1904P	SIDM00230	Small Cell Lung Carcinoma	GDSC	PPTPPQT	DEG_SCF_FBW7_1	0.25
p.Q1904P	SUP-M2	haematopoietic_and_lymphoid_tissue	COSMIC	PPTPPQT	DEG_SCF_FBW7_1	0.25
p.P1921L	TCGA-YG-AA3N	SKCM	TCGA	PPTPPQT	DEG_SCF_FBW7_1	0.1111
p.P1921L	DO51298	SKCM	ICGC	PPTPPQT	DEG_SCF_FBW7_1	0.1111
p.A1902V	SIDM00333	Endometrial Carcinoma	GDSC	PPTPPQT	DEG_SCF_FBW7_1	0.1944
p.A1902V	ACH-000988	Endometrial/Uterine Cancer	CCLE	PPTPPQT	DEG_SCF_FBW7_1	0.1944
p.A1902V	MFE-319	endometrium	COSMIC	PPTPPQT	DEG_SCF_FBW7_1	0.1944
p.Q1898R	ACH-000990	Endometrial/Uterine Cancer	CCLE	PPTPPQT	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q09472	Histone acetyltransferase p300	DEG_SCF_FBW7_1	1907:1913	PPTPPQT	FBXW7	0.993	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons