DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
NPYGSPYTQNP
Uniprot ID:
Q09472
Source protein:
Histone acetyltransferase p300
Source gene:
EP300
Class:
CBL_PTK
Location:
251:261
E3 ligase:
CBL
DEGRON score:
0.9779
ASA_SCORE:
68.2364
COIL:
0.897
CONS_SCORE:
0.3603
DSS_SCORE:
0.6592
HELIX:
0.0506
FCONS_SCORE:
1.0212
RIG_SCORE:
0.6392
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.Y257D
TCGA-37-3783
LUSC
TCGA
NPYGSPYTQNP
CBL_PTK
0.7325
p.Y257D
DO26734
LUSC
ICGC
NPYGSPYTQNP
CBL_PTK
0.7325
p.N249S
TCGA-AX-A0J0
UCEC
TCGA
NPYGSPYTQNP
CBL_PTK
0.2778
p.N249S
DO41133
UCEC
ICGC
NPYGSPYTQNP
CBL_PTK
0.2778
p.T258I
TCGA-B5-A3FA
UCEC
TCGA
NPYGSPYTQNP
CBL_PTK
0.7078
p.T258I
DO52402
UCEC
ICGC
NPYGSPYTQNP
CBL_PTK
0.7078
p.G266A
SIDM01520
Oral Cavity Carcinoma
GDSC
NPYGSPYTQNP
CBL_PTK
0.1944
p.G266A
ACH-000503
Head and Neck Cancer
CCLE
NPYGSPYTQNP
CBL_PTK
0.1944
Drug responses associated with EP300 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NPYGSPYTQNP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q09472
Histone acetyltransferase p300
CBL_PTK
251:261
NPYGSPYTQNP
CBL
0.9779
More...
