DegronMD

Uniprot ID: Q09472

Source protein: Histone acetyltransferase p300

Source gene: EP300

Class: DEG_SCF_FBW7_1

Location: 1875:1882

E3 ligase: FBXW7

DEGRON score: 0.9964

ASA_SCORE: 97.4

COIL: 0.9648

CONS_SCORE: 0.3722

DSS_SCORE: 0.9132

HELIX: 0.0156

FCONS_SCORE: 1.2493

RIG_SCORE: 0.5177

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1877L	TCGA-FS-A1ZK	SKCM	TCGA	PQPTPPNS	DEG_SCF_FBW7_1	0.6471
p.P1877L	DO37474	SKCM	ICGC	PQPTPPNS	DEG_SCF_FBW7_1	0.6471
p.P1880T	DO50940	LICA	ICGC	PQPTPPNS	DEG_SCF_FBW7_1	0.5919
p.S1882N	SIDM00517	Head and Neck Carcinoma	GDSC	PQPTPPNS	DEG_SCF_FBW7_1	0.7069
p.S1882N	ACH-002239	Head and Neck Cancer	CCLE	PQPTPPNS	DEG_SCF_FBW7_1	0.7069
p.S1882N	H3118	upper_aerodigestive_tract	COSMIC	PQPTPPNS	DEG_SCF_FBW7_1	0.7069
p.Q1874E	SIDM00414	Bladder Carcinoma	GDSC	PQPTPPNS	DEG_SCF_FBW7_1	0.3056
p.Q1874E	ACH-000545	Bladder Cancer	CCLE	PQPTPPNS	DEG_SCF_FBW7_1	0.3056
p.Q1874E	VM-CUB-1	urinary_tract	COSMIC	PQPTPPNS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q09472	Histone acetyltransferase p300	DEG_SCF_FBW7_1	1875:1882	PQPTPPNS	FBXW7	0.9964	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons