DegronMD

Uniprot ID: Q09472

Source protein: Histone acetyltransferase p300

Source gene: EP300

Class: DEG_COP1_1

Location: 545:553

E3 ligase: COP1

DEGRON score: 0.9658

ASA_SCORE: 65.5222

COIL: 0.8672

CONS_SCORE: 0.3255

DSS_SCORE: 0.6554

HELIX: 0.0624

FCONS_SCORE: 0.9051

RIG_SCORE: 0.6241

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P555L	TCGA-EB-A5SE	SKCM	TCGA	SENASVPSL	DEG_COP1_1	0.2778
p.P555L	DO47295	SKCM	ICGC	SENASVPSL	DEG_COP1_1	0.2778
p.N538H	DO222718	COCA	ICGC	SENASVPSL	DEG_COP1_1	0.1389
p.P562S	DO222440	ESCA	ICGC	SENASVPSL	DEG_COP1_1	0.0833
p.V550L	DO229026	LICA	ICGC	SENASVPSL	DEG_COP1_1	0.6765
p.M556V	SIDM01526	Mesothelioma	GDSC	SENASVPSL	DEG_COP1_1	0.25
p.T558K	ACH-002080	Neuroblastoma	CCLE	SENASVPSL	DEG_COP1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q09472	Histone acetyltransferase p300	DEG_COP1_1	545:553	SENASVPSL	COP1	0.9658	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons