DegronMD

Uniprot ID: Q09472

Source protein: Histone acetyltransferase p300

Source gene: EP300

Class: DEG_SCF_FBW7_1

Location: 886:891

E3 ligase: FBXW7

DEGRON score: 0.9924

ASA_SCORE: 94.2333

COIL: 0.9445

CONS_SCORE: 0.3761

DSS_SCORE: 0.9332

HELIX: 0.0282

FCONS_SCORE: 1.115

RIG_SCORE: 0.5309

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P881S	DO228896	LICA	ICGC	PTPPTT	DEG_SCF_FBW7_1	0.1944
p.P888S	SIDM00705	Non-Cancerous	GDSC	PTPPTT	DEG_SCF_FBW7_1	0.6752
p.P888S	SIDM00696	Non-Cancerous	GDSC	PTPPTT	DEG_SCF_FBW7_1	0.6752
p.P888S	SIDM00772	Breast Carcinoma	GDSC	PTPPTT	DEG_SCF_FBW7_1	0.6752
p.P888S	ACH-000755	Breast Cancer	CCLE	PTPPTT	DEG_SCF_FBW7_1	0.6752
p.P888S	ACH-002369	Non-Cancerous	CCLE	PTPPTT	DEG_SCF_FBW7_1	0.6752
p.P888S	ACH-002383	Non-Cancerous	CCLE	PTPPTT	DEG_SCF_FBW7_1	0.6752
p.T891P	SIDM01112	Osteosarcoma	GDSC	PTPPTT	DEG_SCF_FBW7_1	0.8142
p.T891P	ACH-000748	Bone Cancer	CCLE	PTPPTT	DEG_SCF_FBW7_1	0.8142
p.T891P	SJSA-1	bone	COSMIC	PTPPTT	DEG_SCF_FBW7_1	0.8142
p.R883G	SIDM01100	Neuroblastoma	GDSC	PTPPTT	DEG_SCF_FBW7_1	0.25
p.R883G	ACH-000366	Neuroblastoma	CCLE	PTPPTT	DEG_SCF_FBW7_1	0.25
p.R883G	SK-N-DZ	autonomic_ganglia	COSMIC	PTPPTT	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02817	Mucin-2	DEG_SCF_FBW7_1	1893:1898	PTPPTT	FBXW7	0.5933	More...
Q09472	Histone acetyltransferase p300	DEG_SCF_FBW7_1	886:891	PTPPTT	FBXW7	0.9924	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons