DegronMD

Uniprot ID: Q02817

Source protein: Mucin-2

Source gene: MUC2

Class: DEG_SCF_FBW7_1

Location: 1893:1898

E3 ligase: FBXW7

DEGRON score: 0.5933

ASA_SCORE: 97.6833

COIL: 0.9693

CONS_SCORE: 0.3612

DSS_SCORE: 0.6774

HELIX: 0.0098

FCONS_SCORE: 1.0191

RIG_SCORE: 0.6501

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M1885V	TCGA-34-8454	LUSC	TCGA	PTPPTT	DEG_SCF_FBW7_1	0.1111
p.T1905I	TCGA-78-7220	LUAD	TCGA	PTPPTT	DEG_SCF_FBW7_1	0.1389
p.T1905I	DO24409	LUAD	ICGC	PTPPTT	DEG_SCF_FBW7_1	0.1389
p.T1905I	ACH-000947	Ovarian Cancer	CCLE	PTPPTT	DEG_SCF_FBW7_1	0.1389
p.A1889T	TCGA-A5-A0VP	UCEC	TCGA	PTPPTT	DEG_SCF_FBW7_1	0.2222
p.A1889T	DO42600	UCEC	ICGC	PTPPTT	DEG_SCF_FBW7_1	0.2222
p.S1892F	TCGA-D3-A8GC	SKCM	TCGA	PTPPTT	DEG_SCF_FBW7_1	0.3056
p.S1892F	DO50281	SKCM	ICGC	PTPPTT	DEG_SCF_FBW7_1	0.3056
p.P1891L	TCGA-DM-A0X9	COAD	TCGA	PTPPTT	DEG_SCF_FBW7_1	0.2778
p.P1891L	DO8618	COAD	ICGC	PTPPTT	DEG_SCF_FBW7_1	0.2778
p.T1886S	TCGA-NH-A50T	COAD	TCGA	PTPPTT	DEG_SCF_FBW7_1	0.1389
p.T1886S	DO44086	COAD	ICGC	PTPPTT	DEG_SCF_FBW7_1	0.1389
p.T1893K	DO233226	GACA	ICGC	PTPPTT	DEG_SCF_FBW7_1	0.7306
p.S1887N	ACH-000979	Prostate Cancer	CCLE	PTPPTT	DEG_SCF_FBW7_1	0.1667
p.S1887I	ACH-001542	Head and Neck Cancer	CCLE	PTPPTT	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02817	Mucin-2	DEG_SCF_FBW7_1	1893:1898	PTPPTT	FBXW7	0.5933	More...
Q09472	Histone acetyltransferase p300	DEG_SCF_FBW7_1	886:891	PTPPTT	FBXW7	0.9924	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons