DegronMD

Uniprot ID: Q09472

Source protein: Histone acetyltransferase p300

Source gene: EP300

Class: DEG_COP1_1

Location: 919:927

E3 ligase: COP1

DEGRON score: 0.9897

ASA_SCORE: 93.7

COIL: 0.9439

CONS_SCORE: 0.3598

DSS_SCORE: 0.7991

HELIX: 0.0463

FCONS_SCORE: 1.0886

RIG_SCORE: 0.5668

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P930L	TCGA-B5-A11E	UCEC	TCGA	STAASVPTP	DEG_COP1_1	0.25
p.P930L	DO41644	UCEC	ICGC	STAASVPTP	DEG_COP1_1	0.25
p.P934T	TCGA-DZ-6133	KIRP	TCGA	STAASVPTP	DEG_COP1_1	0.1389
p.P934T	DO20762	KIRP	ICGC	STAASVPTP	DEG_COP1_1	0.1389
p.R915L	TCGA-E2-A1LK	BRCA	TCGA	STAASVPTP	DEG_COP1_1	0.2222
p.R915L	DO2719	BRCA	ICGC	STAASVPTP	DEG_COP1_1	0.2222
p.P933L	TCGA-FR-A726	SKCM	TCGA	STAASVPTP	DEG_COP1_1	0.1667
p.P933L	DO48665	SKCM	ICGC	STAASVPTP	DEG_COP1_1	0.1667
p.P927S	TCGA-Z2-A8RT	SKCM	TCGA	STAASVPTP	DEG_COP1_1	0.6752
p.P927S	DO51301	SKCM	ICGC	STAASVPTP	DEG_COP1_1	0.6752
p.R915C	DO223057	ESCA	ICGC	STAASVPTP	DEG_COP1_1	0.2222
p.R915C	DO45989	NBL	ICGC	STAASVPTP	DEG_COP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q09472	Histone acetyltransferase p300	DEG_COP1_1	919:927	STAASVPTP	COP1	0.9897	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons