DegronMD

Uniprot ID: Q09472

Source protein: Histone acetyltransferase p300

Source gene: EP300

Class: DEG_SCF_FBW7_1

Location: 1866:1872

E3 ligase: FBXW7

DEGRON score: 0.9476

ASA_SCORE: 103.0571

COIL: 0.9643

CONS_SCORE: 0.2916

DSS_SCORE: 0.9505

HELIX: 0.0129

FCONS_SCORE: 0.8637

RIG_SCORE: 0.5236

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1864S	TCGA-FB-AAQ6	PAAD	TCGA	PQTPQPT	DEG_SCF_FBW7_1	0.2778
p.T1864S	DO218971	PAAD	ICGC	PQTPQPT	DEG_SCF_FBW7_1	0.2778
p.P1866L	SIDM00290	Gastric Carcinoma	GDSC	PQTPQPT	DEG_SCF_FBW7_1	0.6471
p.P1866L	ACH-000847	Gastric Cancer	CCLE	PQTPQPT	DEG_SCF_FBW7_1	0.6471
p.P1866L	ACH-002446	Gastric Cancer	CCLE	PQTPQPT	DEG_SCF_FBW7_1	0.6471
p.P1866L	HGC-27	stomach	COSMIC	PQTPQPT	DEG_SCF_FBW7_1	0.6471
p.Q1874E	SIDM00414	Bladder Carcinoma	GDSC	PQTPQPT	DEG_SCF_FBW7_1	0.2778
p.Q1874E	ACH-000545	Bladder Cancer	CCLE	PQTPQPT	DEG_SCF_FBW7_1	0.2778
p.Q1874E	VM-CUB-1	urinary_tract	COSMIC	PQTPQPT	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q09472	Histone acetyltransferase p300	DEG_SCF_FBW7_1	1866:1872	PQTPQPT	FBXW7	0.9476	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons