DegronMD

Uniprot ID: Q09472

Source protein: Histone acetyltransferase p300

Source gene: EP300

Class: DEG_SCF_FBW7_1

Location: 840:845

E3 ligase: FBXW7

DEGRON score: 0.9945

ASA_SCORE: 113.15

COIL: 0.9797

CONS_SCORE: 0.3414

DSS_SCORE: 0.8733

HELIX: 0.0083

FCONS_SCORE: 1.0603

RIG_SCORE: 0.4984

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R838C	TCGA-AA-3715	COAD	TCGA	PTPHHT	DEG_SCF_FBW7_1	0.2778
p.R838C	DO8018	COAD	ICGC	PTPHHT	DEG_SCF_FBW7_1	0.2778
p.R838C	ACH-001061	Colon/Colorectal Cancer	CCLE	PTPHHT	DEG_SCF_FBW7_1	0.2778
p.P840T	TCGA-AG-A002	READ	TCGA	PTPHHT	DEG_SCF_FBW7_1	0.7031
p.S833L	TCGA-D8-A1XM	BRCA	TCGA	PTPHHT	DEG_SCF_FBW7_1	0.5833
p.S833L	DO2605	BRCA	ICGC	PTPHHT	DEG_SCF_FBW7_1	0.5833
p.S833L	SIDM02013	Colorectal Carcinoma	GDSC	PTPHHT	DEG_SCF_FBW7_1	0.5833
p.Q853R	DO51108	PRAD	ICGC	PTPHHT	DEG_SCF_FBW7_1	0.1111
p.P842S	SIDM01096	Colorectal Carcinoma	GDSC	PTPHHT	DEG_SCF_FBW7_1	0.6752
p.P842S	ACH-000400	Colon/Colorectal Cancer	CCLE	PTPHHT	DEG_SCF_FBW7_1	0.6752
p.P842S	SK-CO-1	large_intestine	COSMIC	PTPHHT	DEG_SCF_FBW7_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q09472	Histone acetyltransferase p300	DEG_SCF_FBW7_1	840:845	PTPHHT	FBXW7	0.9945	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons