DegronMD - Q8IX01(SUGP2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M782I	TCGA-86-8278	LUAD	TCGA	PQTSS	DEG_SPOP_SBC_1	769:773	Mutation rewiring degron network	0.0833
p.M782I	DO26308	LUAD	ICGC	PQTSS	DEG_SPOP_SBC_1	769:773	Mutation rewiring degron network	0.0833
p.V57I	TCGA-AP-A056	UCEC	TCGA	RAEMYDD	LIG_APCC_ABBAyCdc20_2	50:56	Mutation rewiring degron network	0.3056
p.V57I	DO43971	UCEC	ICGC	RAEMYDD	LIG_APCC_ABBAyCdc20_2	50:56	Mutation rewiring degron network	0.3056
p.A778D	TCGA-AP-A059	UCEC	TCGA	PQTSS	DEG_SPOP_SBC_1	769:773	Mutation rewiring degron network	0.1944
p.A778D	DO41361	UCEC	ICGC	PQTSS	DEG_SPOP_SBC_1	769:773	Mutation rewiring degron network	0.1944
p.D764G	TCGA-BR-6452	STAD	TCGA	PQTSS	DEG_SPOP_SBC_1	769:773	Mutation rewiring degron network	0.1944
p.D764G	DO38404	STAD	ICGC	PQTSS	DEG_SPOP_SBC_1	769:773	Mutation rewiring degron network	0.1944
p.D55N	TCGA-BS-A0TA	UCEC	TCGA	RAEMYDD	LIG_APCC_ABBAyCdc20_2	50:56	Mutation altering degron motif	0.5821
p.D55N	DO43298	UCEC	ICGC	RAEMYDD	LIG_APCC_ABBAyCdc20_2	50:56	Mutation altering degron motif	0.5821
p.P47S	TCGA-D3-A8GL	SKCM	TCGA	RAEMYDD	LIG_APCC_ABBAyCdc20_2	50:56	Mutation rewiring degron network	0.25
p.P47S	DO50287	SKCM	ICGC	RAEMYDD	LIG_APCC_ABBAyCdc20_2	50:56	Mutation rewiring degron network	0.25
p.K759E	TCGA-EY-A1GI	UCEC	TCGA	PQTSS	DEG_SPOP_SBC_1	769:773	Mutation substituting flanking lysine	0.1667
p.K759E	DO41211	UCEC	ICGC	PQTSS	DEG_SPOP_SBC_1	769:773	Mutation substituting flanking lysine	0.1667
p.E52K	TCGA-KQ-A41N	BLCA	TCGA	RAEMYDD	LIG_APCC_ABBAyCdc20_2	50:56	Mutation altering degron motif	0.591
p.E52K	DO223588	BLCA	ICGC	RAEMYDD	LIG_APCC_ABBAyCdc20_2	50:56	Mutation altering degron motif	0.591
p.C775F	DO889	BOCA	ICGC	PQTSS	DEG_SPOP_SBC_1	769:773	Mutation rewiring degron network	0.2778
p.S763F	DO2665	BRCA	ICGC	PQTSS	DEG_SPOP_SBC_1	769:773	Mutation rewiring degron network	0.1667
p.H58N	DO228948	LICA	ICGC	RAEMYDD	LIG_APCC_ABBAyCdc20_2	50:56	Mutation rewiring degron network	0.2778
p.D780N	DO52226	LIHC	ICGC	PQTSS	DEG_SPOP_SBC_1	769:773	Mutation rewiring degron network	0.1389
p.Y63C	DO228338	MALY	ICGC	RAEMYDD	LIG_APCC_ABBAyCdc20_2	50:56	Mutation rewiring degron network	0.1389
p.Y63C	ACH-002232	Lymphoma	CCLE	RAEMYDD	LIG_APCC_ABBAyCdc20_2	50:56	Mutation rewiring degron network	0.1389
p.Y63C	DG-75	haematopoietic and lymphoid tissue	COSMIC	RAEMYDD	LIG_APCC_ABBAyCdc20_2	50:56	Mutation rewiring degron network	0.1389
p.A778S	DO228584	MALY	ICGC	PQTSS	DEG_SPOP_SBC_1	769:773	Mutation rewiring degron network	0.1944
p.A51T	DO33063	PACA	ICGC	RAEMYDD	LIG_APCC_ABBAyCdc20_2	50:56	Mutation altering degron motif	0.6028
p.Q761R	SIDM02039	Colorectal Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	769:773	Mutation rewiring degron network	0.1111
p.R64T	SIDM00133	Non-Small Cell Lung Carcinoma	GDSC	RAEMYDD	LIG_APCC_ABBAyCdc20_2	50:56	Mutation rewiring degron network	0.1111
p.R64T	HOP-62	lung	COSMIC	RAEMYDD	LIG_APCC_ABBAyCdc20_2	50:56	Mutation rewiring degron network	0.1111
p.R50T	ACH-000861	Lung Cancer	CCLE	RAEMYDD	LIG_APCC_ABBAyCdc20_2	50:56	Mutation altering degron motif	0.7876
p.R50T	HOP-62	lung	COSMIC	RAEMYDD	LIG_APCC_ABBAyCdc20_2	50:56	Mutation altering degron motif	0.7876

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SUGP2

UniProt ID: Q8IX01

Entrez ID: 10147

Protein name: SURP and G-patch domain-containing protein 2 (Arginine/serine-rich-splicing factor 14) (Splicing factor, arginine/serine-rich 14)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SUGP2 in