DegronMD

Uniprot ID: Q8IX01

Source protein: SURP and G-patch domain-containing protein 2

Source gene: SUGP2

Class: LIG_APCC_ABBAyCdc20_2

Location: 50:56

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9874

ASA_SCORE: 75.0571

COIL: 0.3904

CONS_SCORE: 0.5199

DSS_SCORE: 0.4267

HELIX: 0.5744

FCONS_SCORE: 1.0489

RIG_SCORE: 0.7344

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V57I	TCGA-AP-A056	UCEC	TCGA	RAEMYDD	LIG_APCC_ABBAyCdc20_2	0.3056
p.V57I	DO43971	UCEC	ICGC	RAEMYDD	LIG_APCC_ABBAyCdc20_2	0.3056
p.D55N	TCGA-BS-A0TA	UCEC	TCGA	RAEMYDD	LIG_APCC_ABBAyCdc20_2	0.5821
p.D55N	DO43298	UCEC	ICGC	RAEMYDD	LIG_APCC_ABBAyCdc20_2	0.5821
p.P47S	TCGA-D3-A8GL	SKCM	TCGA	RAEMYDD	LIG_APCC_ABBAyCdc20_2	0.25
p.P47S	DO50287	SKCM	ICGC	RAEMYDD	LIG_APCC_ABBAyCdc20_2	0.25
p.E52K	TCGA-KQ-A41N	BLCA	TCGA	RAEMYDD	LIG_APCC_ABBAyCdc20_2	0.591
p.E52K	DO223588	BLCA	ICGC	RAEMYDD	LIG_APCC_ABBAyCdc20_2	0.591
p.H58N	DO228948	LICA	ICGC	RAEMYDD	LIG_APCC_ABBAyCdc20_2	0.2778
p.Y63C	DO228338	MALY	ICGC	RAEMYDD	LIG_APCC_ABBAyCdc20_2	0.1389
p.Y63C	ACH-002232	Lymphoma	CCLE	RAEMYDD	LIG_APCC_ABBAyCdc20_2	0.1389
p.Y63C	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	RAEMYDD	LIG_APCC_ABBAyCdc20_2	0.1389
p.A51T	DO33063	PACA	ICGC	RAEMYDD	LIG_APCC_ABBAyCdc20_2	0.6028
p.R64T	SIDM00133	Non-Small Cell Lung Carcinoma	GDSC	RAEMYDD	LIG_APCC_ABBAyCdc20_2	0.1111
p.R64T	HOP-62	lung	COSMIC	RAEMYDD	LIG_APCC_ABBAyCdc20_2	0.1111
p.R50T	ACH-000861	Lung Cancer	CCLE	RAEMYDD	LIG_APCC_ABBAyCdc20_2	0.7876
p.R50T	HOP-62	lung	COSMIC	RAEMYDD	LIG_APCC_ABBAyCdc20_2	0.7876

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IX01	SURP and G-patch domain-containing protein 2	LIG_APCC_ABBAyCdc20_2	50:56	RAEMYDD	APC,CDC20,FZR1	0.9874	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons