DegronMD - Q13023(AKAP6)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P556T	TCGA-04-1361	OV	TCGA	ASTSS	DEG_SPOP_SBC_1	549:553	Mutation rewiring degron network	0.25
p.P556T	DO32606	OV	ICGC	ASTSS	DEG_SPOP_SBC_1	549:553	Mutation rewiring degron network	0.25
p.A2239S	TCGA-33-6737	LUSC	TCGA	NLEFTPSK	DEG_SCF_SKP2-CKS1_1	2241:2248	Mutation rewiring degron network	0.2778
p.A2239S	TCGA-33-6737	LUSC	TCGA	PQTSS	DEG_SPOP_SBC_1	2232:2236	Mutation rewiring degron network	0.25
p.A2239S	DO26866	LUSC	ICGC	NLEFTPSK	DEG_SCF_SKP2-CKS1_1	2241:2248	Mutation rewiring degron network	0.2778
p.A2239S	DO26866	LUSC	ICGC	PQTSS	DEG_SPOP_SBC_1	2232:2236	Mutation rewiring degron network	0.25
p.S2247L	TCGA-55-6968	LUAD	TCGA	NLEFTPSK	DEG_SCF_SKP2-CKS1_1	2241:2248	Mutation altering degron motif	0.6556
p.S2247L	DO23759	LUAD	ICGC	NLEFTPSK	DEG_SCF_SKP2-CKS1_1	2241:2248	Mutation altering degron motif	0.6556
p.E35D	TCGA-64-5779	LUAD	TCGA	INMTPTVE	DEG_SCF_FBW7_2	28:35	Mutation altering degron motif	0.6758
p.E35D	DO24930	LUAD	ICGC	INMTPTVE	DEG_SCF_FBW7_2	28:35	Mutation altering degron motif	0.6758
p.S450F	TCGA-69-7980	LUAD	TCGA	DRSKLCLVL	DEG_APCC_DBOX_1	433:441	Mutation rewiring degron network	0.0833
p.S450F	DO23678	LUAD	ICGC	DRSKLCLVL	DEG_APCC_DBOX_1	433:441	Mutation rewiring degron network	0.0833
p.S424C	TCGA-86-7954	LUAD	TCGA	DRSKLCLVL	DEG_APCC_DBOX_1	433:441	Mutation rewiring degron network	0.0833
p.S424C	DO23660	LUAD	ICGC	DRSKLCLVL	DEG_APCC_DBOX_1	433:441	Mutation rewiring degron network	0.0833
p.K436N	TCGA-AA-A00N	COAD	TCGA	DRSKLCLVL	DEG_APCC_DBOX_1	433:441	Mutation altering degron motif	0.5806
p.K436N	DO9876	COAD	ICGC	DRSKLCLVL	DEG_APCC_DBOX_1	433:441	Mutation altering degron motif	0.5806
p.E2240Q	TCGA-AO-A03M	BRCA	TCGA	NLEFTPSK	DEG_SCF_SKP2-CKS1_1	2241:2248	Mutation rewiring degron network	0.3056
p.E2240Q	TCGA-AO-A03M	BRCA	TCGA	PQTSS	DEG_SPOP_SBC_1	2232:2236	Mutation rewiring degron network	0.2222
p.E2240Q	DO2216	BRCA	ICGC	NLEFTPSK	DEG_SCF_SKP2-CKS1_1	2241:2248	Mutation rewiring degron network	0.3056
p.E2240Q	DO2216	BRCA	ICGC	PQTSS	DEG_SPOP_SBC_1	2232:2236	Mutation rewiring degron network	0.2222
p.P431H	TCGA-AX-A2HC	UCEC	TCGA	DRSKLCLVL	DEG_APCC_DBOX_1	433:441	Mutation rewiring degron network	0.2778
p.P431H	DO41572	UCEC	ICGC	DRSKLCLVL	DEG_APCC_DBOX_1	433:441	Mutation rewiring degron network	0.2778
p.N29S	TCGA-B5-A3FA	UCEC	TCGA	INMTPTVE	DEG_SCF_FBW7_2	28:35	Mutation altering degron motif	0.5958
p.N29S	DO52402	UCEC	ICGC	INMTPTVE	DEG_SCF_FBW7_2	28:35	Mutation altering degron motif	0.5958
p.D2250G	TCGA-B5-A3FA	UCEC	TCGA	NLEFTPSK	DEG_SCF_SKP2-CKS1_1	2241:2248	Mutation rewiring degron network	0.2778
p.D2250G	DO52402	UCEC	ICGC	NLEFTPSK	DEG_SCF_SKP2-CKS1_1	2241:2248	Mutation rewiring degron network	0.2778
p.E555K	TCGA-BH-A1EV	BRCA	TCGA	ASTSS	DEG_SPOP_SBC_1	549:553	Mutation rewiring degron network	0.2778
p.E555K	DO1797	BRCA	ICGC	ASTSS	DEG_SPOP_SBC_1	549:553	Mutation rewiring degron network	0.2778
p.L333V	TCGA-C5-A1MH	CESC	TCGA	SSSSGE	DEG_Kelch_Keap1_1	326:331	Mutation rewiring degron network	0.2778
p.L333V	TCGA-C5-A1MH	CESC	TCGA	VSSSS	DEG_SPOP_SBC_1	325:329	Mutation rewiring degron network	0.2222
p.L333V	DO48982	CESC	ICGC	SSSSGE	DEG_Kelch_Keap1_1	326:331	Mutation rewiring degron network	0.2778
p.L333V	DO48982	CESC	ICGC	VSSSS	DEG_SPOP_SBC_1	325:329	Mutation rewiring degron network	0.2222
p.G2257R	TCGA-CS-5394	LGG	TCGA	NLEFTPSK	DEG_SCF_SKP2-CKS1_1	2241:2248	Mutation rewiring degron network	0.0833
p.G2257R	DO22273	LGG	ICGC	NLEFTPSK	DEG_SCF_SKP2-CKS1_1	2241:2248	Mutation rewiring degron network	0.0833
p.G2257R	DO34032	PACA	ICGC	NLEFTPSK	DEG_SCF_SKP2-CKS1_1	2241:2248	Mutation rewiring degron network	0.0833
p.S548C	TCGA-DR-A0ZM	CESC	TCGA	ASTSS	DEG_SPOP_SBC_1	549:553	Mutation rewiring degron network	0.3056
p.S548C	DO6254	CESC	ICGC	ASTSS	DEG_SPOP_SBC_1	549:553	Mutation rewiring degron network	0.3056
p.S435C	TCGA-E2-A1LH	BRCA	TCGA	DRSKLCLVL	DEG_APCC_DBOX_1	433:441	Mutation altering degron motif	0.643
p.P25H	TCGA-EE-A2MQ	SKCM	TCGA	INMTPTVE	DEG_SCF_FBW7_2	28:35	Mutation rewiring degron network	0.25
p.P25H	DO37810	SKCM	ICGC	INMTPTVE	DEG_SCF_FBW7_2	28:35	Mutation rewiring degron network	0.25
p.G709V	TCGA-EE-A3AD	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	698:702	Mutation rewiring degron network	0.1389
p.G709V	DO37707	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	698:702	Mutation rewiring degron network	0.1389
p.G324W	TCGA-ER-A19Q	SKCM	TCGA	SSSSGE	DEG_Kelch_Keap1_1	326:331	Mutation rewiring degron network	0.2778
p.G324W	TCGA-ER-A19Q	SKCM	TCGA	VSSSS	DEG_SPOP_SBC_1	325:329	Mutation rewiring degron network	0.3056
p.G324W	DO47497	SKCM	ICGC	SSSSGE	DEG_Kelch_Keap1_1	326:331	Mutation rewiring degron network	0.2778
p.G324W	DO47497	SKCM	ICGC	VSSSS	DEG_SPOP_SBC_1	325:329	Mutation rewiring degron network	0.3056
p.S706Y	TCGA-ER-A19T	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	698:702	Mutation rewiring degron network	0.2222
p.S706Y	DO51251	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	698:702	Mutation rewiring degron network	0.2222
p.S700L	TCGA-ER-A2NE	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	698:702	Mutation altering degron motif	0.7667
p.S700L	DO48663	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	698:702	Mutation altering degron motif	0.7667
p.P446L	TCGA-FR-A729	SKCM	TCGA	DRSKLCLVL	DEG_APCC_DBOX_1	433:441	Mutation rewiring degron network	0.1944
p.P446L	DO48618	SKCM	ICGC	DRSKLCLVL	DEG_APCC_DBOX_1	433:441	Mutation rewiring degron network	0.1944
p.S707L	TCGA-GM-A2DL	BRCA	TCGA	PSSSS	DEG_SPOP_SBC_1	698:702	Mutation rewiring degron network	0.1944
p.S707L	DO1497	BRCA	ICGC	PSSSS	DEG_SPOP_SBC_1	698:702	Mutation rewiring degron network	0.1944
p.E2243K	TCGA-GN-A269	SKCM	TCGA	NLEFTPSK	DEG_SCF_SKP2-CKS1_1	2241:2248	Mutation altering degron motif	0.7022
p.E2243K	DO37483	SKCM	ICGC	NLEFTPSK	DEG_SCF_SKP2-CKS1_1	2241:2248	Mutation altering degron motif	0.7022
p.P2246L	TCGA-IH-A3EA	SKCM	TCGA	NLEFTPSK	DEG_SCF_SKP2-CKS1_1	2241:2248	Mutation altering degron motif	0.7582
p.P2246L	DO220881	MELA	ICGC	NLEFTPSK	DEG_SCF_SKP2-CKS1_1	2241:2248	Mutation altering degron motif	0.7582
p.P2246L	DO37667	SKCM	ICGC	NLEFTPSK	DEG_SCF_SKP2-CKS1_1	2241:2248	Mutation altering degron motif	0.7582
p.A337V	DO228483	BRCA	ICGC	SSSSGE	DEG_Kelch_Keap1_1	326:331	Mutation rewiring degron network	0.1667
p.A337V	DO228483	BRCA	ICGC	VSSSS	DEG_SPOP_SBC_1	325:329	Mutation rewiring degron network	0.1111
p.A337V	DO229010	COCA	ICGC	SSSSGE	DEG_Kelch_Keap1_1	326:331	Mutation rewiring degron network	0.1667
p.A337V	DO229010	COCA	ICGC	VSSSS	DEG_SPOP_SBC_1	325:329	Mutation rewiring degron network	0.1111
p.A337V	DO229346	LAML	ICGC	SSSSGE	DEG_Kelch_Keap1_1	326:331	Mutation rewiring degron network	0.1667
p.A337V	DO229346	LAML	ICGC	VSSSS	DEG_SPOP_SBC_1	325:329	Mutation rewiring degron network	0.1111
p.A337V	DO230659	LAML	ICGC	SSSSGE	DEG_Kelch_Keap1_1	326:331	Mutation rewiring degron network	0.1667
p.A337V	DO230659	LAML	ICGC	VSSSS	DEG_SPOP_SBC_1	325:329	Mutation rewiring degron network	0.1111
p.A337V	DO225404	LAML	ICGC	SSSSGE	DEG_Kelch_Keap1_1	326:331	Mutation rewiring degron network	0.1667
p.A337V	DO225404	LAML	ICGC	VSSSS	DEG_SPOP_SBC_1	325:329	Mutation rewiring degron network	0.1111
p.A337V	DO231140	LAML	ICGC	SSSSGE	DEG_Kelch_Keap1_1	326:331	Mutation rewiring degron network	0.1667
p.A337V	DO231140	LAML	ICGC	VSSSS	DEG_SPOP_SBC_1	325:329	Mutation rewiring degron network	0.1111
p.A337V	DO229047	LICA	ICGC	SSSSGE	DEG_Kelch_Keap1_1	326:331	Mutation rewiring degron network	0.1667
p.A337V	DO229047	LICA	ICGC	VSSSS	DEG_SPOP_SBC_1	325:329	Mutation rewiring degron network	0.1111
p.A337V	DO52365	LUSC	ICGC	SSSSGE	DEG_Kelch_Keap1_1	326:331	Mutation rewiring degron network	0.1667
p.A337V	DO52365	LUSC	ICGC	VSSSS	DEG_SPOP_SBC_1	325:329	Mutation rewiring degron network	0.1111
p.L437P	DO223137	ESCA	ICGC	DRSKLCLVL	DEG_APCC_DBOX_1	433:441	Mutation altering degron motif	0.7582
p.S328F	DO233682	GACA	ICGC	SSSSGE	DEG_Kelch_Keap1_1	326:331	Mutation altering degron motif	0.7982
p.S328F	DO233682	GACA	ICGC	VSSSS	DEG_SPOP_SBC_1	325:329	Mutation altering degron motif	0.7982
p.D703G	DO233936	GACA	ICGC	PSSSS	DEG_SPOP_SBC_1	698:702	Mutation rewiring degron network	0.3056
p.N2241D	SIDM00061	Ovarian Carcinoma	GDSC	NLEFTPSK	DEG_SCF_SKP2-CKS1_1	2241:2248	Mutation altering degron motif	0.5821
p.N563I	SIDM00399	Head and Neck Carcinoma	GDSC	ASTSS	DEG_SPOP_SBC_1	549:553	Mutation rewiring degron network	0.0556
p.N563I	SCC90	upper aerodigestive tract	COSMIC	ASTSS	DEG_SPOP_SBC_1	549:553	Mutation rewiring degron network	0.0556
p.G543A	SIDM00789	Colorectal Carcinoma	GDSC	ASTSS	DEG_SPOP_SBC_1	549:553	Mutation rewiring degron network	0.1667
p.G543A	ACH-000997	Colon/Colorectal Cancer	CCLE	ASTSS	DEG_SPOP_SBC_1	549:553	Mutation rewiring degron network	0.1667
p.G543A	HCT-15	large intestine	COSMIC	ASTSS	DEG_SPOP_SBC_1	549:553	Mutation rewiring degron network	0.1667
p.M43I	SIDM00193	Colorectal Carcinoma	GDSC	INMTPTVE	DEG_SCF_FBW7_2	28:35	Mutation rewiring degron network	0.1111
p.M43I	ACH-000991	Colon/Colorectal Cancer	CCLE	INMTPTVE	DEG_SCF_FBW7_2	28:35	Mutation rewiring degron network	0.1111
p.M43I	SNU-81	large intestine	COSMIC	INMTPTVE	DEG_SCF_FBW7_2	28:35	Mutation rewiring degron network	0.1111
p.S444Y	SIDM01168	Colorectal Carcinoma	GDSC	DRSKLCLVL	DEG_APCC_DBOX_1	433:441	Mutation rewiring degron network	0.25
p.S444Y	ACH-001399	Colon/Colorectal Cancer	CCLE	DRSKLCLVL	DEG_APCC_DBOX_1	433:441	Mutation rewiring degron network	0.25
p.S444Y	SW626	ovary	COSMIC	DRSKLCLVL	DEG_APCC_DBOX_1	433:441	Mutation rewiring degron network	0.25
p.T691A	SIDM00251	Gastric Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	698:702	Mutation rewiring degron network	0.1389
p.T691A	TGBC11TKB	stomach	COSMIC	PSSSS	DEG_SPOP_SBC_1	698:702	Mutation rewiring degron network	0.1389
p.K2248N	SIDM00574	Glioblastoma	GDSC	NLEFTPSK	DEG_SCF_SKP2-CKS1_1	2241:2248	Mutation altering degron motif	0.6918
p.K2248N	ACH-001605	Brain Cancer	CCLE	NLEFTPSK	DEG_SCF_SKP2-CKS1_1	2241:2248	Mutation altering degron motif	0.6918
p.K2248N	no-10	central nervous system	COSMIC	NLEFTPSK	DEG_SCF_SKP2-CKS1_1	2241:2248	Mutation altering degron motif	0.6918
p.G543W	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	ASTSS	DEG_SPOP_SBC_1	549:553	Mutation rewiring degron network	0.1667
p.G543W	ACH-000878	Lung Cancer	CCLE	ASTSS	DEG_SPOP_SBC_1	549:553	Mutation rewiring degron network	0.1667
p.G543W	HCC-15	lung	COSMIC	ASTSS	DEG_SPOP_SBC_1	549:553	Mutation rewiring degron network	0.1667
p.P544S	SIDM00145	T-Lymphoblastic Leukemia	GDSC	ASTSS	DEG_SPOP_SBC_1	549:553	Mutation rewiring degron network	0.1944
p.P544S	ACH-001127	Leukemia	CCLE	ASTSS	DEG_SPOP_SBC_1	549:553	Mutation rewiring degron network	0.1944
p.P544S	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	ASTSS	DEG_SPOP_SBC_1	549:553	Mutation rewiring degron network	0.1944
p.E40V	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	INMTPTVE	DEG_SCF_FBW7_2	28:35	Mutation rewiring degron network	0.1944
p.E40V	ACH-000912	Lung Cancer	CCLE	INMTPTVE	DEG_SCF_FBW7_2	28:35	Mutation rewiring degron network	0.1944
p.S2235F	ACH-002396	Bone Cancer	CCLE	PQTSS	DEG_SPOP_SBC_1	2232:2236	Mutation altering degron motif	0.7982
p.S2235F	Sarc9371	bone	COSMIC	PQTSS	DEG_SPOP_SBC_1	2232:2236	Mutation altering degron motif	0.7982

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AKAP6

UniProt ID: Q13023

Entrez ID: 9472

Protein name: A-kinase anchor protein 6 (AKAP-6) (A-kinase anchor protein 100 kDa) (AKAP 100) (Protein kinase A-anchoring protein 6) (PRKA6) (mAKAP)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for AKAP6 in