DegronMD

Uniprot ID: Q13023

Source protein: A-kinase anchor protein 6

Source gene: AKAP6

Class: DEG_APCC_DBOX_1

Location: 433:441

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6622

ASA_SCORE: 72.2889

COIL: 0.3767

CONS_SCORE: 0.842

DSS_SCORE: 0.4774

HELIX: 0.4626

FCONS_SCORE: 1.0517

RIG_SCORE: 0.7794

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S450F	TCGA-69-7980	LUAD	TCGA	DRSKLCLVL	DEG_APCC_DBOX_1	0.0833
p.S450F	DO23678	LUAD	ICGC	DRSKLCLVL	DEG_APCC_DBOX_1	0.0833
p.S424C	TCGA-86-7954	LUAD	TCGA	DRSKLCLVL	DEG_APCC_DBOX_1	0.0833
p.S424C	DO23660	LUAD	ICGC	DRSKLCLVL	DEG_APCC_DBOX_1	0.0833
p.K436N	TCGA-AA-A00N	COAD	TCGA	DRSKLCLVL	DEG_APCC_DBOX_1	0.5806
p.K436N	DO9876	COAD	ICGC	DRSKLCLVL	DEG_APCC_DBOX_1	0.5806
p.P431H	TCGA-AX-A2HC	UCEC	TCGA	DRSKLCLVL	DEG_APCC_DBOX_1	0.2778
p.P431H	DO41572	UCEC	ICGC	DRSKLCLVL	DEG_APCC_DBOX_1	0.2778
p.S435C	TCGA-E2-A1LH	BRCA	TCGA	DRSKLCLVL	DEG_APCC_DBOX_1	0.643
p.P446L	TCGA-FR-A729	SKCM	TCGA	DRSKLCLVL	DEG_APCC_DBOX_1	0.1944
p.P446L	DO48618	SKCM	ICGC	DRSKLCLVL	DEG_APCC_DBOX_1	0.1944
p.L437P	DO223137	ESCA	ICGC	DRSKLCLVL	DEG_APCC_DBOX_1	0.7582
p.S444Y	SIDM01168	Colorectal Carcinoma	GDSC	DRSKLCLVL	DEG_APCC_DBOX_1	0.25
p.S444Y	ACH-001399	Colon/Colorectal Cancer	CCLE	DRSKLCLVL	DEG_APCC_DBOX_1	0.25
p.S444Y	SW626	ovary	COSMIC	DRSKLCLVL	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13023	A-kinase anchor protein 6	DEG_APCC_DBOX_1	433:441	DRSKLCLVL	APC,CDC20,FZR1	0.6622	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons