DegronMD

Uniprot ID: Q13023

Source protein: A-kinase anchor protein 6

Source gene: AKAP6

Class: DEG_SCF_FBW7_2

Location: 28:35

E3 ligase: FBXW7

DEGRON score: 0.9897

ASA_SCORE: 78.175

COIL: 0.7328

CONS_SCORE: 0.7016

DSS_SCORE: 0.7182

HELIX: 0.1586

FCONS_SCORE: 1.0812

RIG_SCORE: 0.6838

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E35D	TCGA-64-5779	LUAD	TCGA	INMTPTVE	DEG_SCF_FBW7_2	0.6758
p.E35D	DO24930	LUAD	ICGC	INMTPTVE	DEG_SCF_FBW7_2	0.6758
p.N29S	TCGA-B5-A3FA	UCEC	TCGA	INMTPTVE	DEG_SCF_FBW7_2	0.5958
p.N29S	DO52402	UCEC	ICGC	INMTPTVE	DEG_SCF_FBW7_2	0.5958
p.P25H	TCGA-EE-A2MQ	SKCM	TCGA	INMTPTVE	DEG_SCF_FBW7_2	0.25
p.P25H	DO37810	SKCM	ICGC	INMTPTVE	DEG_SCF_FBW7_2	0.25
p.M43I	SIDM00193	Colorectal Carcinoma	GDSC	INMTPTVE	DEG_SCF_FBW7_2	0.1111
p.M43I	ACH-000991	Colon/Colorectal Cancer	CCLE	INMTPTVE	DEG_SCF_FBW7_2	0.1111
p.M43I	SNU-81	large_intestine	COSMIC	INMTPTVE	DEG_SCF_FBW7_2	0.1111
p.E40V	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	INMTPTVE	DEG_SCF_FBW7_2	0.1944
p.E40V	ACH-000912	Lung Cancer	CCLE	INMTPTVE	DEG_SCF_FBW7_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13023	A-kinase anchor protein 6	DEG_SCF_FBW7_2	28:35	INMTPTVE	FBXW7	0.9897	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons